MUC1: Structure, Function, and Clinic Application in Epithelial Cancers
The transmembrane glycoprotein mucin 1 (MUC1) is a mucin family member that has different functions in normal and cancer cells. Owing to its structural and biochemical properties, MUC1 can act as a lubricant, moisturizer, and physical barrier in normal cells. However, in cancer cells, MUC1 often und...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/12/6567 |
| _version_ | 1797529649055531008 |
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| author | Wenqing Chen Zhu Zhang Shiqing Zhang Peili Zhu Joshua Ka-Shun Ko Ken Kin-Lam Yung |
| author_facet | Wenqing Chen Zhu Zhang Shiqing Zhang Peili Zhu Joshua Ka-Shun Ko Ken Kin-Lam Yung |
| author_sort | Wenqing Chen |
| collection | DOAJ |
| description | The transmembrane glycoprotein mucin 1 (MUC1) is a mucin family member that has different functions in normal and cancer cells. Owing to its structural and biochemical properties, MUC1 can act as a lubricant, moisturizer, and physical barrier in normal cells. However, in cancer cells, MUC1 often undergoes aberrant glycosylation and overexpression. It is involved in cancer invasion, metastasis, angiogenesis, and apoptosis by virtue of its participation in intracellular signaling processes and the regulation of related biomolecules. This review introduces the biological structure and different roles of MUC1 in normal and cancer cells and the regulatory mechanisms governing these roles. It also evaluates current research progress and the clinical applications of MUC1 in cancer therapy based on its characteristics. |
| first_indexed | 2024-03-10T10:16:44Z |
| format | Article |
| id | doaj.art-9979707a8e5b4322806b4f14714cba63 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:16:44Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9979707a8e5b4322806b4f14714cba632023-11-22T00:44:49ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012212656710.3390/ijms22126567MUC1: Structure, Function, and Clinic Application in Epithelial CancersWenqing Chen0Zhu Zhang1Shiqing Zhang2Peili Zhu3Joshua Ka-Shun Ko4Ken Kin-Lam Yung5Division of Teaching and Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, ChinaDepartment of Biology, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong, ChinaDepartment of Biology, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong, ChinaDepartment of Biology, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong, ChinaDivision of Teaching and Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, ChinaDepartment of Biology, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong, ChinaThe transmembrane glycoprotein mucin 1 (MUC1) is a mucin family member that has different functions in normal and cancer cells. Owing to its structural and biochemical properties, MUC1 can act as a lubricant, moisturizer, and physical barrier in normal cells. However, in cancer cells, MUC1 often undergoes aberrant glycosylation and overexpression. It is involved in cancer invasion, metastasis, angiogenesis, and apoptosis by virtue of its participation in intracellular signaling processes and the regulation of related biomolecules. This review introduces the biological structure and different roles of MUC1 in normal and cancer cells and the regulatory mechanisms governing these roles. It also evaluates current research progress and the clinical applications of MUC1 in cancer therapy based on its characteristics.https://www.mdpi.com/1422-0067/22/12/6567MUC1epithelial cancerMUC1 cell barriertumor oncogenetherapeutic biomarkersimmunotherapy |
| spellingShingle | Wenqing Chen Zhu Zhang Shiqing Zhang Peili Zhu Joshua Ka-Shun Ko Ken Kin-Lam Yung MUC1: Structure, Function, and Clinic Application in Epithelial Cancers International Journal of Molecular Sciences MUC1 epithelial cancer MUC1 cell barrier tumor oncogene therapeutic biomarkers immunotherapy |
| title | MUC1: Structure, Function, and Clinic Application in Epithelial Cancers |
| title_full | MUC1: Structure, Function, and Clinic Application in Epithelial Cancers |
| title_fullStr | MUC1: Structure, Function, and Clinic Application in Epithelial Cancers |
| title_full_unstemmed | MUC1: Structure, Function, and Clinic Application in Epithelial Cancers |
| title_short | MUC1: Structure, Function, and Clinic Application in Epithelial Cancers |
| title_sort | muc1 structure function and clinic application in epithelial cancers |
| topic | MUC1 epithelial cancer MUC1 cell barrier tumor oncogene therapeutic biomarkers immunotherapy |
| url | https://www.mdpi.com/1422-0067/22/12/6567 |
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