POLYPRENYL PHOSPHATES AS ADJUVANTS, POLARIZING THE IMMUNE RESPONSE TO Th1
Abstract. The attempts to decrease a toxic action of Freund complete adjuvant have led to development of new emulsion adjuvant compositions. More often they are based on metabolizable oil (squalene) with addition the Tween 80 (Polisorbate 80) as an emulsifier. The third component is an immunomodulat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Sankt-Peterburg : NIIÈM imeni Pastera
2014-07-01
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| Series: | Инфекция и иммунитет |
| Subjects: | |
| Online Access: | https://www.iimmun.ru/iimm/article/view/80 |
| _version_ | 1797973090290892800 |
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| author | A. V. Pronin S. V. Ozherelkov A. V. Deyeva A. V. Sanin A. N. Narovljansky |
| author_facet | A. V. Pronin S. V. Ozherelkov A. V. Deyeva A. V. Sanin A. N. Narovljansky |
| author_sort | A. V. Pronin |
| collection | DOAJ |
| description | Abstract. The attempts to decrease a toxic action of Freund complete adjuvant have led to development of new emulsion adjuvant compositions. More often they are based on metabolizable oil (squalene) with addition the Tween 80 (Polisorbate 80) as an emulsifier. The third component is an immunomodulator. Adjuvants, intended for prevention of virus infections, should include the immunomodulators polarizing the immune response to Th1. From this point of view adjuvant based on a colloidal solution prepared by means of the Tween 80 from polyprenyl phasphates of fir needles (Phosprenyl) can be rather perspective. The last one, as well as squalene, is constructed by isoprene links, but has them not 6, but 16 that essentially reduces its toxicity. The obtained data shows that Phosprenyl essentially enhances efficiency of vaccination in such virus infections as tick born encephalitis, bird flu, poliomyelitis and polarizes the immune response to Th1. |
| first_indexed | 2024-04-11T03:58:38Z |
| format | Article |
| id | doaj.art-997a505ca302445c9356a0fec44b8be6 |
| institution | Directory Open Access Journal |
| issn | 2220-7619 2313-7398 |
| language | Russian |
| last_indexed | 2024-04-11T03:58:38Z |
| publishDate | 2014-07-01 |
| publisher | Sankt-Peterburg : NIIÈM imeni Pastera |
| record_format | Article |
| series | Инфекция и иммунитет |
| spelling | doaj.art-997a505ca302445c9356a0fec44b8be62023-01-02T00:08:14ZrusSankt-Peterburg : NIIÈM imeni PasteraИнфекция и иммунитет2220-76192313-73982014-07-012364565010.15789/2220-7619-2012-3-645-65080POLYPRENYL PHOSPHATES AS ADJUVANTS, POLARIZING THE IMMUNE RESPONSE TO Th1A. V. Pronin0S. V. Ozherelkov1A. V. Deyeva2A. V. Sanin3A. N. Narovljansky4ФГБУ НИИЭМ им. Н.Ф. Гамалеи Минздравсоцразвития РФ, МоскваНИИ полиомиелита и вирусных энцефалитов им. М.П. Чумакова РАМН, Московская областьФГБУ НИИЭМ им. Н.Ф. Гамалеи Минздравсоцразвития РФ, МоскваФГБУ НИИЭМ им. Н.Ф. Гамалеи Минздравсоцразвития РФ, МоскваФГБУ НИИЭМ им. Н.Ф. Гамалеи Минздравсоцразвития РФ, МоскваAbstract. The attempts to decrease a toxic action of Freund complete adjuvant have led to development of new emulsion adjuvant compositions. More often they are based on metabolizable oil (squalene) with addition the Tween 80 (Polisorbate 80) as an emulsifier. The third component is an immunomodulator. Adjuvants, intended for prevention of virus infections, should include the immunomodulators polarizing the immune response to Th1. From this point of view adjuvant based on a colloidal solution prepared by means of the Tween 80 from polyprenyl phasphates of fir needles (Phosprenyl) can be rather perspective. The last one, as well as squalene, is constructed by isoprene links, but has them not 6, but 16 that essentially reduces its toxicity. The obtained data shows that Phosprenyl essentially enhances efficiency of vaccination in such virus infections as tick born encephalitis, bird flu, poliomyelitis and polarizes the immune response to Th1.https://www.iimmun.ru/iimm/article/view/80adjuvantpolyprenolvirus infections |
| spellingShingle | A. V. Pronin S. V. Ozherelkov A. V. Deyeva A. V. Sanin A. N. Narovljansky POLYPRENYL PHOSPHATES AS ADJUVANTS, POLARIZING THE IMMUNE RESPONSE TO Th1 Инфекция и иммунитет adjuvant polyprenol virus infections |
| title | POLYPRENYL PHOSPHATES AS ADJUVANTS, POLARIZING THE IMMUNE RESPONSE TO Th1 |
| title_full | POLYPRENYL PHOSPHATES AS ADJUVANTS, POLARIZING THE IMMUNE RESPONSE TO Th1 |
| title_fullStr | POLYPRENYL PHOSPHATES AS ADJUVANTS, POLARIZING THE IMMUNE RESPONSE TO Th1 |
| title_full_unstemmed | POLYPRENYL PHOSPHATES AS ADJUVANTS, POLARIZING THE IMMUNE RESPONSE TO Th1 |
| title_short | POLYPRENYL PHOSPHATES AS ADJUVANTS, POLARIZING THE IMMUNE RESPONSE TO Th1 |
| title_sort | polyprenyl phosphates as adjuvants polarizing the immune response to th1 |
| topic | adjuvant polyprenol virus infections |
| url | https://www.iimmun.ru/iimm/article/view/80 |
| work_keys_str_mv | AT avpronin polyprenylphosphatesasadjuvantspolarizingtheimmuneresponsetoth1 AT svozherelkov polyprenylphosphatesasadjuvantspolarizingtheimmuneresponsetoth1 AT avdeyeva polyprenylphosphatesasadjuvantspolarizingtheimmuneresponsetoth1 AT avsanin polyprenylphosphatesasadjuvantspolarizingtheimmuneresponsetoth1 AT annarovljansky polyprenylphosphatesasadjuvantspolarizingtheimmuneresponsetoth1 |