Genetic and Epigenetic Instability of Stem Cells
Recently, research on stem cells has been receiving an increasing amount of attention, both for its advantages and disadvantages. Genetic and epigenetic instabilities among stem cells have been a recurring obstacle to progress in regenerative medicine using stem cells. Various reports have stated th...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2014-05-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.3727/096368914X678472 |
| _version_ | 1818846998318546944 |
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| author | Karthyayani Rajamani Yuan-Sheng Li Dean-Kuo Hsieh Shinn-Zong Lin Horng-Jyh Harn Tzyy-Wen Chiou Ph.D. |
| author_facet | Karthyayani Rajamani Yuan-Sheng Li Dean-Kuo Hsieh Shinn-Zong Lin Horng-Jyh Harn Tzyy-Wen Chiou Ph.D. |
| author_sort | Karthyayani Rajamani |
| collection | DOAJ |
| description | Recently, research on stem cells has been receiving an increasing amount of attention, both for its advantages and disadvantages. Genetic and epigenetic instabilities among stem cells have been a recurring obstacle to progress in regenerative medicine using stem cells. Various reports have stated that these instabilities can transform stem cells when transferred in vivo and thus have the potential to develop tumors. Previous research has shown that various extrinsic and intrinsic factors can contribute to the stability of stem cells. The extrinsic factors include growth supplements, growth factors, oxygen tension, passage technique, and cryopreservation. Controlling these factors based on previous reports may assist researchers in developing strategies for the production and clinical application of “safe” stem cells. On the other hand, the intrinsic factors can be unpredictable and uncontrollable; therefore, to ensure the successful use of stem cells in regenerative medicine, it is imperative to develop and implement appropriate strategies and technique for culturing stem cells and to confirm the genetic and epigenetic safety of these stem cells before employing them in clinical trials. |
| first_indexed | 2024-12-19T05:54:27Z |
| format | Article |
| id | doaj.art-997af3fa5dfd41f28fe1979fa149ed28 |
| institution | Directory Open Access Journal |
| issn | 0963-6897 1555-3892 |
| language | English |
| last_indexed | 2024-12-19T05:54:27Z |
| publishDate | 2014-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-997af3fa5dfd41f28fe1979fa149ed282022-12-21T20:33:30ZengSAGE PublishingCell Transplantation0963-68971555-38922014-05-012310.3727/096368914X678472Genetic and Epigenetic Instability of Stem CellsKarthyayani Rajamani0Yuan-Sheng Li1Dean-Kuo Hsieh2Shinn-Zong Lin3Horng-Jyh Harn4Tzyy-Wen Chiou Ph.D.5Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, TaiwanDepartment of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, TaiwanDepartment of Applied Chemistry, Chaoyang University of Technology, Taichung, TaiwanDepartment of Neurosurgery, China Medical University Beigan Hospital, Yunlin, TaiwanDepartment of Pathology, China Medical University and Hospital, Taichung, TaiwanDepartment of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, TaiwanRecently, research on stem cells has been receiving an increasing amount of attention, both for its advantages and disadvantages. Genetic and epigenetic instabilities among stem cells have been a recurring obstacle to progress in regenerative medicine using stem cells. Various reports have stated that these instabilities can transform stem cells when transferred in vivo and thus have the potential to develop tumors. Previous research has shown that various extrinsic and intrinsic factors can contribute to the stability of stem cells. The extrinsic factors include growth supplements, growth factors, oxygen tension, passage technique, and cryopreservation. Controlling these factors based on previous reports may assist researchers in developing strategies for the production and clinical application of “safe” stem cells. On the other hand, the intrinsic factors can be unpredictable and uncontrollable; therefore, to ensure the successful use of stem cells in regenerative medicine, it is imperative to develop and implement appropriate strategies and technique for culturing stem cells and to confirm the genetic and epigenetic safety of these stem cells before employing them in clinical trials.https://doi.org/10.3727/096368914X678472 |
| spellingShingle | Karthyayani Rajamani Yuan-Sheng Li Dean-Kuo Hsieh Shinn-Zong Lin Horng-Jyh Harn Tzyy-Wen Chiou Ph.D. Genetic and Epigenetic Instability of Stem Cells Cell Transplantation |
| title | Genetic and Epigenetic Instability of Stem Cells |
| title_full | Genetic and Epigenetic Instability of Stem Cells |
| title_fullStr | Genetic and Epigenetic Instability of Stem Cells |
| title_full_unstemmed | Genetic and Epigenetic Instability of Stem Cells |
| title_short | Genetic and Epigenetic Instability of Stem Cells |
| title_sort | genetic and epigenetic instability of stem cells |
| url | https://doi.org/10.3727/096368914X678472 |
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