RAP GTPases and platelet integrin signaling
Platelets are highly specialized cells that continuously patrol the vasculature to ensure its integrity (hemostasis). At sites of vascular injury, they are able to respond to trace amounts of agonists and to rapidly transition from an anti-adhesive/patrolling to an adhesive state (integrin inside-ou...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-01-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2018.1476681 |
| _version_ | 1797684280915132416 |
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| author | Lucia Stefanini Wolfgang Bergmeier |
| author_facet | Lucia Stefanini Wolfgang Bergmeier |
| author_sort | Lucia Stefanini |
| collection | DOAJ |
| description | Platelets are highly specialized cells that continuously patrol the vasculature to ensure its integrity (hemostasis). At sites of vascular injury, they are able to respond to trace amounts of agonists and to rapidly transition from an anti-adhesive/patrolling to an adhesive state (integrin inside-out activation) required for hemostatic plug formation. Pathological conditions that disturb the balance in the underlying signaling processes can lead to unwanted platelet activation (thrombosis) or to an increased bleeding risk. The small GTPases of the RAP subfamily, highly expressed in platelets, are critical regulators of cell adhesion, cytoskeleton remodeling, and MAP kinase signaling. Studies by our group and others demonstrate that RAP GTPases, in particular RAP1A and RAP1B, are the key molecular switches that turn on platelet activation/adhesiveness at sites of injury. In this review, we will summarize major findings on the role of RAP GTPases in platelet biology with a focus on the signaling pathways leading to the conversion of integrins to a high-affinity state. |
| first_indexed | 2024-03-12T00:27:11Z |
| format | Article |
| id | doaj.art-997c08cbb5884adcb67b2b5aada85ad9 |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:27:11Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-997c08cbb5884adcb67b2b5aada85ad92023-09-15T10:31:59ZengTaylor & Francis GroupPlatelets0953-71041369-16352019-01-01301414710.1080/09537104.2018.14766811476681RAP GTPases and platelet integrin signalingLucia Stefanini0Wolfgang Bergmeier1Sapienza University of RomeUniversity of North CarolinaPlatelets are highly specialized cells that continuously patrol the vasculature to ensure its integrity (hemostasis). At sites of vascular injury, they are able to respond to trace amounts of agonists and to rapidly transition from an anti-adhesive/patrolling to an adhesive state (integrin inside-out activation) required for hemostatic plug formation. Pathological conditions that disturb the balance in the underlying signaling processes can lead to unwanted platelet activation (thrombosis) or to an increased bleeding risk. The small GTPases of the RAP subfamily, highly expressed in platelets, are critical regulators of cell adhesion, cytoskeleton remodeling, and MAP kinase signaling. Studies by our group and others demonstrate that RAP GTPases, in particular RAP1A and RAP1B, are the key molecular switches that turn on platelet activation/adhesiveness at sites of injury. In this review, we will summarize major findings on the role of RAP GTPases in platelet biology with a focus on the signaling pathways leading to the conversion of integrins to a high-affinity state.http://dx.doi.org/10.1080/09537104.2018.1476681hemostasisintegrin activationrap1signal transductionsmall gtpases |
| spellingShingle | Lucia Stefanini Wolfgang Bergmeier RAP GTPases and platelet integrin signaling Platelets hemostasis integrin activation rap1 signal transduction small gtpases |
| title | RAP GTPases and platelet integrin signaling |
| title_full | RAP GTPases and platelet integrin signaling |
| title_fullStr | RAP GTPases and platelet integrin signaling |
| title_full_unstemmed | RAP GTPases and platelet integrin signaling |
| title_short | RAP GTPases and platelet integrin signaling |
| title_sort | rap gtpases and platelet integrin signaling |
| topic | hemostasis integrin activation rap1 signal transduction small gtpases |
| url | http://dx.doi.org/10.1080/09537104.2018.1476681 |
| work_keys_str_mv | AT luciastefanini rapgtpasesandplateletintegrinsignaling AT wolfgangbergmeier rapgtpasesandplateletintegrinsignaling |