Epidemiological and clinical characteristics of cutaneous leishmaniasis and their relationship with the laboratory data, south of Brazil
Objective: To evaluate clinical, epidemiological and laboratorial aspects for the understanding of the disease characteristics and its relationship with diagnostic tests. Methods: A retrospective, descriptive and analytical study involving 2,660 American cutaneous leishmaniasis (ACL) suspected patie...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2011-01-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867011701337 |
| _version_ | 1818554199178215424 |
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| author | Maura Cristiani de Moura Curti Thaís Gomes Verzignassi Silveira Sandra Mara Alessi Aristides Arraes Dennis Armando Bertolini Paulo Donizeti Zanzarini Eneide Aparecida Sabaini Venazzi Andrea Cláudia Silva Fernandes Jorge Juarez Vieira Teixeira Maria Valdrinez Campana Lonardoni |
| author_facet | Maura Cristiani de Moura Curti Thaís Gomes Verzignassi Silveira Sandra Mara Alessi Aristides Arraes Dennis Armando Bertolini Paulo Donizeti Zanzarini Eneide Aparecida Sabaini Venazzi Andrea Cláudia Silva Fernandes Jorge Juarez Vieira Teixeira Maria Valdrinez Campana Lonardoni |
| author_sort | Maura Cristiani de Moura Curti |
| collection | DOAJ |
| description | Objective: To evaluate clinical, epidemiological and laboratorial aspects for the understanding of the disease characteristics and its relationship with diagnostic tests. Methods: A retrospective, descriptive and analytical study involving 2,660 American cutaneous leishmaniasis (ACL) suspected patients from southern Brazil was undertaken between April 1986 and December 2005. Data on population characteristics and laboratory tests were obtained. Diagnostic laboratory tests used were direct search for Leishmania spp. (DS), Montenegro skin test (MST) and indirect immunofluorescent assay (IFA). Results: 62.3% of patients were positive for at least one laboratory test. DS test was positive in 65.1%; MST in 92.3% and IFA in 70.0%. Although Cohen's Kappa test did not reveal any agreement with laboratory diagnosis for ACL, the association between MST and IFA tests increased positiveness to 98.9%; MST and DS to 97.2%; and IFA and DS to 85%. IFA and MST positiveness were higher among patients with ≤ 2-month lesion-evolution time. Most ACL patients were male (72.6%) in the age range of 15–49 years, featuring lesions during two months or less (53.9%) and a cutaneous form of the disease (88.0%). Conclusion: Findings suggest that for the adequate identification of ACL cases a combination of laboratory tests that involves the association of MST with at least another test should be used. Keywords: clinical laboratory techniques, disease transmission, infectious, cutaneous leishmaniasis, epidemiology |
| first_indexed | 2024-12-12T09:36:13Z |
| format | Article |
| id | doaj.art-997c66352380408ea4b96eec9fd99573 |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-12-12T09:36:13Z |
| publishDate | 2011-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-997c66352380408ea4b96eec9fd995732022-12-22T00:28:43ZengElsevierBrazilian Journal of Infectious Diseases1413-86702011-01-011511216Epidemiological and clinical characteristics of cutaneous leishmaniasis and their relationship with the laboratory data, south of BrazilMaura Cristiani de Moura Curti0Thaís Gomes Verzignassi Silveira1Sandra Mara Alessi Aristides Arraes2Dennis Armando Bertolini3Paulo Donizeti Zanzarini4Eneide Aparecida Sabaini Venazzi5Andrea Cláudia Silva Fernandes6Jorge Juarez Vieira Teixeira7Maria Valdrinez Campana Lonardoni8Master's Degree, Universidade Estadual de Maringá (UEM/LEPAC)PhD, UEM/LEPACPhD, UEM/LEPACPhD, UEM/LEPACSpecialist, UEM/LEPACMaster's Degree, Universidade Estadual de Maringá (UEM/LEPAC)Master's Degree, Universidade Estadual de Maringá (UEM/LEPAC)PhD, UEM/LEPACPhD, UEM/LEPAC; Correspondence to: Avenida Colombo, 5790 CEP 87020-900 Maringá - PR, Brasil CEP: 87020-900.Objective: To evaluate clinical, epidemiological and laboratorial aspects for the understanding of the disease characteristics and its relationship with diagnostic tests. Methods: A retrospective, descriptive and analytical study involving 2,660 American cutaneous leishmaniasis (ACL) suspected patients from southern Brazil was undertaken between April 1986 and December 2005. Data on population characteristics and laboratory tests were obtained. Diagnostic laboratory tests used were direct search for Leishmania spp. (DS), Montenegro skin test (MST) and indirect immunofluorescent assay (IFA). Results: 62.3% of patients were positive for at least one laboratory test. DS test was positive in 65.1%; MST in 92.3% and IFA in 70.0%. Although Cohen's Kappa test did not reveal any agreement with laboratory diagnosis for ACL, the association between MST and IFA tests increased positiveness to 98.9%; MST and DS to 97.2%; and IFA and DS to 85%. IFA and MST positiveness were higher among patients with ≤ 2-month lesion-evolution time. Most ACL patients were male (72.6%) in the age range of 15–49 years, featuring lesions during two months or less (53.9%) and a cutaneous form of the disease (88.0%). Conclusion: Findings suggest that for the adequate identification of ACL cases a combination of laboratory tests that involves the association of MST with at least another test should be used. Keywords: clinical laboratory techniques, disease transmission, infectious, cutaneous leishmaniasis, epidemiologyhttp://www.sciencedirect.com/science/article/pii/S1413867011701337 |
| spellingShingle | Maura Cristiani de Moura Curti Thaís Gomes Verzignassi Silveira Sandra Mara Alessi Aristides Arraes Dennis Armando Bertolini Paulo Donizeti Zanzarini Eneide Aparecida Sabaini Venazzi Andrea Cláudia Silva Fernandes Jorge Juarez Vieira Teixeira Maria Valdrinez Campana Lonardoni Epidemiological and clinical characteristics of cutaneous leishmaniasis and their relationship with the laboratory data, south of Brazil Brazilian Journal of Infectious Diseases |
| title | Epidemiological and clinical characteristics of cutaneous leishmaniasis and their relationship with the laboratory data, south of Brazil |
| title_full | Epidemiological and clinical characteristics of cutaneous leishmaniasis and their relationship with the laboratory data, south of Brazil |
| title_fullStr | Epidemiological and clinical characteristics of cutaneous leishmaniasis and their relationship with the laboratory data, south of Brazil |
| title_full_unstemmed | Epidemiological and clinical characteristics of cutaneous leishmaniasis and their relationship with the laboratory data, south of Brazil |
| title_short | Epidemiological and clinical characteristics of cutaneous leishmaniasis and their relationship with the laboratory data, south of Brazil |
| title_sort | epidemiological and clinical characteristics of cutaneous leishmaniasis and their relationship with the laboratory data south of brazil |
| url | http://www.sciencedirect.com/science/article/pii/S1413867011701337 |
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