Anticancer applications of phytochemicals in gastric cancer: Effects and molecular mechanism
Gastric cancer (GC) is the fourth most common malignant cancer and is a life-threatening disease worldwide. Phytochemicals have been shown to be a rational, safe, non-toxic, and very promising approach to the prevention and treatment of cancer. It has been found that phytochemicals have protective e...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1078090/full |
| _version_ | 1797955367607468032 |
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| author | Zhaofeng Liang Zhaofeng Liang Yumeng Xu Yue Zhang Xinyi Zhang Jiajia Song Jianhua Jin Hui Qian Hui Qian |
| author_facet | Zhaofeng Liang Zhaofeng Liang Yumeng Xu Yue Zhang Xinyi Zhang Jiajia Song Jianhua Jin Hui Qian Hui Qian |
| author_sort | Zhaofeng Liang |
| collection | DOAJ |
| description | Gastric cancer (GC) is the fourth most common malignant cancer and is a life-threatening disease worldwide. Phytochemicals have been shown to be a rational, safe, non-toxic, and very promising approach to the prevention and treatment of cancer. It has been found that phytochemicals have protective effects against GC through inhibiting cell proliferation, inducing apoptosis and autophagy, suppressing cell invasion and migration, anti-angiogenesis, inhibit Helicobacter pylori infection, regulating the microenvironment. In recent years, the role of phytochemicals in the occurrence, development, drug resistance and prognosis of GC has attracted more and more attention. In order to better understand the relationship between phytochemicals and gastric cancer, we briefly summarize the roles and functions of phytochemicals in GC tumorigenesis, development and prognosis. This review will probably help guide the public to prevent the occurrence and development of GC through phytochemicals, and develop functional foods or drugs for the prevention and treatment of gastric cancer. |
| first_indexed | 2024-04-10T23:31:59Z |
| format | Article |
| id | doaj.art-997ce40c32ca4564b23433875378691d |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-10T23:31:59Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-997ce40c32ca4564b23433875378691d2023-01-12T04:54:05ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-01-011310.3389/fphar.2022.10780901078090Anticancer applications of phytochemicals in gastric cancer: Effects and molecular mechanismZhaofeng Liang0Zhaofeng Liang1Yumeng Xu2Yue Zhang3Xinyi Zhang4Jiajia Song5Jianhua Jin6Hui Qian7Hui Qian8Wujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Wujin Hospital Affiliated with Jiangsu University, Chang Zhou, ChinaDepartment of laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, ChinaDepartment of laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, ChinaDepartment of laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, ChinaDepartment of laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, ChinaDepartment of laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, ChinaWujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Wujin Hospital Affiliated with Jiangsu University, Chang Zhou, ChinaWujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Wujin Hospital Affiliated with Jiangsu University, Chang Zhou, ChinaDepartment of laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, ChinaGastric cancer (GC) is the fourth most common malignant cancer and is a life-threatening disease worldwide. Phytochemicals have been shown to be a rational, safe, non-toxic, and very promising approach to the prevention and treatment of cancer. It has been found that phytochemicals have protective effects against GC through inhibiting cell proliferation, inducing apoptosis and autophagy, suppressing cell invasion and migration, anti-angiogenesis, inhibit Helicobacter pylori infection, regulating the microenvironment. In recent years, the role of phytochemicals in the occurrence, development, drug resistance and prognosis of GC has attracted more and more attention. In order to better understand the relationship between phytochemicals and gastric cancer, we briefly summarize the roles and functions of phytochemicals in GC tumorigenesis, development and prognosis. This review will probably help guide the public to prevent the occurrence and development of GC through phytochemicals, and develop functional foods or drugs for the prevention and treatment of gastric cancer.https://www.frontiersin.org/articles/10.3389/fphar.2022.1078090/fullgastric cancerphytochemicalspreventiontreatmentmechanisms |
| spellingShingle | Zhaofeng Liang Zhaofeng Liang Yumeng Xu Yue Zhang Xinyi Zhang Jiajia Song Jianhua Jin Hui Qian Hui Qian Anticancer applications of phytochemicals in gastric cancer: Effects and molecular mechanism Frontiers in Pharmacology gastric cancer phytochemicals prevention treatment mechanisms |
| title | Anticancer applications of phytochemicals in gastric cancer: Effects and molecular mechanism |
| title_full | Anticancer applications of phytochemicals in gastric cancer: Effects and molecular mechanism |
| title_fullStr | Anticancer applications of phytochemicals in gastric cancer: Effects and molecular mechanism |
| title_full_unstemmed | Anticancer applications of phytochemicals in gastric cancer: Effects and molecular mechanism |
| title_short | Anticancer applications of phytochemicals in gastric cancer: Effects and molecular mechanism |
| title_sort | anticancer applications of phytochemicals in gastric cancer effects and molecular mechanism |
| topic | gastric cancer phytochemicals prevention treatment mechanisms |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1078090/full |
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