Roles of plasma leptin and resistin in novel subgroups of type 2 diabetes driven by cluster analysis
Abstract Background A novel classification has been introduced to promote precision medicine in diabetes. The current study aimed to investigate the relationship between leptin and resistin levels with novel refined subgroups in patients with type 2 diabetes mellitus (T2DM). Methods The k-means anal...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | Lipids in Health and Disease |
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| Online Access: | https://doi.org/10.1186/s12944-022-01623-z |
| _version_ | 1818750272582713344 |
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| author | Xuemin Peng Jiaojiao Huang Huajie Zou Bei Peng Sanshan Xia Kun Dong Nan Sun Jing Tao Yan Yang |
| author_facet | Xuemin Peng Jiaojiao Huang Huajie Zou Bei Peng Sanshan Xia Kun Dong Nan Sun Jing Tao Yan Yang |
| author_sort | Xuemin Peng |
| collection | DOAJ |
| description | Abstract Background A novel classification has been introduced to promote precision medicine in diabetes. The current study aimed to investigate the relationship between leptin and resistin levels with novel refined subgroups in patients with type 2 diabetes mellitus (T2DM). Methods The k-means analysis was conducted to cluster 541 T2DM patients into the following four subgroups: mild obesity-related diabetes (MOD), severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD) and mild age-related diabetes (MARD). Individuals meeting the exclusion criteria were eliminated, the data for 285 patients were analyzed. Characteristics were determined using various clinical parameters. Both the leptin and resistin levels were determined using enzyme-linked immunosorbent assay. Results The highest levels of plasma leptin were in the MOD group with relatively lower levels in the SIDD and SIRD groups (P < 0.001). The SIRD group had a higher resistin concentration than the MARD group (P = 0.024) while no statistical significance in resistin levels was found between the SIDD and MOD groups. Logistic regression demonstrated that plasma resistin was associated with a higher risk of diabetic nephropathy (odds ratios (OR) = 2.255, P = 0.001). According to receiver operating characteristic (ROC) curves, the area under the curve (AUC) of resistin (0.748, 95% CI 0.610–0.887) was significantly greater than that of HOMA2-IR (0.447, 95% CI 0.280–0.614) (P < 0.05) for diabetic nephropathy in the SIRD group. Conclusions Leptin levels were different in four subgroups of T2DM and were highest in the MOD group. Resistin was elevated in the SIRD group and was closely related to diabetic nephropathy. |
| first_indexed | 2024-12-18T04:17:02Z |
| format | Article |
| id | doaj.art-997e4a076bef48adb45b9de3cf6085aa |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-18T04:17:02Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-997e4a076bef48adb45b9de3cf6085aa2022-12-21T21:21:19ZengBMCLipids in Health and Disease1476-511X2022-01-0121111010.1186/s12944-022-01623-zRoles of plasma leptin and resistin in novel subgroups of type 2 diabetes driven by cluster analysisXuemin Peng0Jiaojiao Huang1Huajie Zou2Bei Peng3Sanshan Xia4Kun Dong5Nan Sun6Jing Tao7Yan Yang8Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyBranch of National Clinical Research Center for Metabolic DiseasesDepartment of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Background A novel classification has been introduced to promote precision medicine in diabetes. The current study aimed to investigate the relationship between leptin and resistin levels with novel refined subgroups in patients with type 2 diabetes mellitus (T2DM). Methods The k-means analysis was conducted to cluster 541 T2DM patients into the following four subgroups: mild obesity-related diabetes (MOD), severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD) and mild age-related diabetes (MARD). Individuals meeting the exclusion criteria were eliminated, the data for 285 patients were analyzed. Characteristics were determined using various clinical parameters. Both the leptin and resistin levels were determined using enzyme-linked immunosorbent assay. Results The highest levels of plasma leptin were in the MOD group with relatively lower levels in the SIDD and SIRD groups (P < 0.001). The SIRD group had a higher resistin concentration than the MARD group (P = 0.024) while no statistical significance in resistin levels was found between the SIDD and MOD groups. Logistic regression demonstrated that plasma resistin was associated with a higher risk of diabetic nephropathy (odds ratios (OR) = 2.255, P = 0.001). According to receiver operating characteristic (ROC) curves, the area under the curve (AUC) of resistin (0.748, 95% CI 0.610–0.887) was significantly greater than that of HOMA2-IR (0.447, 95% CI 0.280–0.614) (P < 0.05) for diabetic nephropathy in the SIRD group. Conclusions Leptin levels were different in four subgroups of T2DM and were highest in the MOD group. Resistin was elevated in the SIRD group and was closely related to diabetic nephropathy.https://doi.org/10.1186/s12944-022-01623-zType 2 diabetes mellitusLeptinResistinCluster analysisNovel subgroups |
| spellingShingle | Xuemin Peng Jiaojiao Huang Huajie Zou Bei Peng Sanshan Xia Kun Dong Nan Sun Jing Tao Yan Yang Roles of plasma leptin and resistin in novel subgroups of type 2 diabetes driven by cluster analysis Lipids in Health and Disease Type 2 diabetes mellitus Leptin Resistin Cluster analysis Novel subgroups |
| title | Roles of plasma leptin and resistin in novel subgroups of type 2 diabetes driven by cluster analysis |
| title_full | Roles of plasma leptin and resistin in novel subgroups of type 2 diabetes driven by cluster analysis |
| title_fullStr | Roles of plasma leptin and resistin in novel subgroups of type 2 diabetes driven by cluster analysis |
| title_full_unstemmed | Roles of plasma leptin and resistin in novel subgroups of type 2 diabetes driven by cluster analysis |
| title_short | Roles of plasma leptin and resistin in novel subgroups of type 2 diabetes driven by cluster analysis |
| title_sort | roles of plasma leptin and resistin in novel subgroups of type 2 diabetes driven by cluster analysis |
| topic | Type 2 diabetes mellitus Leptin Resistin Cluster analysis Novel subgroups |
| url | https://doi.org/10.1186/s12944-022-01623-z |
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