Monitoring small airway dysfunction in connective tissue disease-related interstitial lung disease: a retrospective and prospective study
Abstract Background Small airway dysfunction (SAD), a hallmark of early lung function abnormality, is a major component of several chronic respiratory disorders. The role of SAD in patients with connective tissue disease-related interstitial lung disease (CTD-ILD) has not been explored. Methods We c...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-03-01
|
| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12890-023-02381-z |
| _version_ | 1797865684973125632 |
|---|---|
| author | Linrui Xu Giacomo Sgalla Faping Wang Min Zhu Liangyuan Li Ping Li Qibing Xie Xiaoyan Lv Jianqun Yu Gang Wang Huajing Wan Luca Richeldi Fengming Luo |
| author_facet | Linrui Xu Giacomo Sgalla Faping Wang Min Zhu Liangyuan Li Ping Li Qibing Xie Xiaoyan Lv Jianqun Yu Gang Wang Huajing Wan Luca Richeldi Fengming Luo |
| author_sort | Linrui Xu |
| collection | DOAJ |
| description | Abstract Background Small airway dysfunction (SAD), a hallmark of early lung function abnormality, is a major component of several chronic respiratory disorders. The role of SAD in patients with connective tissue disease-related interstitial lung disease (CTD-ILD) has not been explored. Methods We conducted a two-parts (retrospective and prospective) study to collect pulmonary function tests from CTD-ILD patients. SAD was defined as at least two of the three measures (MMEF, FEF 50%, and FEF 75%) must be 65% of predicted values. Spearman correlation coefficient was used to evaluate association between SAD and other pulmonary function parameters. Mixed effects regression modeling analysis was used to assess response to treatment. Results CTD-ILD patients with SAD and without SAD were compared in this study. In the retrospective study, pulmonary function tests (PFTs) from 491 CTD-ILD patients were evaluated, SAD were identified in 233 (47.5%). CTD-ILD patients with SAD were less smokers (17.6% vs. 27.9%, p = 0.007) and more females (74.3% vs. 64.0%, p = 0.015) than those without SAD. CTD-ILD patients with SAD had lower vital capacity (% predicted FVC, 70.4 ± 18.3 vs. 80.0 ± 20.9, p < 0.001) and lower diffusion capacity (% predicted DLCO, 58.8 ± 19.7 vs. 63.8 ± 22.1, p = 0.011) than those without SAD. Among 87 CTD-ILD patients prospectively enrolled, significant improvement in % predicted FVC was observed at 12-months follow-up (6.37 ± 1.53, p < 0.001 in patients with SAD; 5.13 ± 1.53, p = 0.002 in patients without SAD), but not in diffusion capacity and SAD parameters. Conclusion In our cohort, about half of CTD-ILD patients have SAD, which is less frequent in smokers and more common in female patients. CTD-ILD patients with SAD have worse pulmonary function compared to those without SAD. Improvement of FVC but no improvement of SAD was observed in CTD-ILD patients after treatment. |
| first_indexed | 2024-04-09T23:12:08Z |
| format | Article |
| id | doaj.art-997ed0da28ed42f08d88d6b4d2be778a |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-04-09T23:12:08Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-997ed0da28ed42f08d88d6b4d2be778a2023-03-22T10:19:00ZengBMCBMC Pulmonary Medicine1471-24662023-03-0123111110.1186/s12890-023-02381-zMonitoring small airway dysfunction in connective tissue disease-related interstitial lung disease: a retrospective and prospective studyLinrui Xu0Giacomo Sgalla1Faping Wang2Min Zhu3Liangyuan Li4Ping Li5Qibing Xie6Xiaoyan Lv7Jianqun Yu8Gang Wang9Huajing Wan10Luca Richeldi11Fengming Luo12Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan UniversityDivision of Pulmonary Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro CuoreDepartment of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan UniversityDepartment of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan UniversityDepartment of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan UniversityDepartment of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan UniversityDepartment of Rheumatology and Immunology, West China Hospital, Sichuan UniversityDepartment of Dermatology, West China Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan UniversityDepartment of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan UniversityDivision of Pulmonary Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro CuoreDepartment of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan UniversityAbstract Background Small airway dysfunction (SAD), a hallmark of early lung function abnormality, is a major component of several chronic respiratory disorders. The role of SAD in patients with connective tissue disease-related interstitial lung disease (CTD-ILD) has not been explored. Methods We conducted a two-parts (retrospective and prospective) study to collect pulmonary function tests from CTD-ILD patients. SAD was defined as at least two of the three measures (MMEF, FEF 50%, and FEF 75%) must be 65% of predicted values. Spearman correlation coefficient was used to evaluate association between SAD and other pulmonary function parameters. Mixed effects regression modeling analysis was used to assess response to treatment. Results CTD-ILD patients with SAD and without SAD were compared in this study. In the retrospective study, pulmonary function tests (PFTs) from 491 CTD-ILD patients were evaluated, SAD were identified in 233 (47.5%). CTD-ILD patients with SAD were less smokers (17.6% vs. 27.9%, p = 0.007) and more females (74.3% vs. 64.0%, p = 0.015) than those without SAD. CTD-ILD patients with SAD had lower vital capacity (% predicted FVC, 70.4 ± 18.3 vs. 80.0 ± 20.9, p < 0.001) and lower diffusion capacity (% predicted DLCO, 58.8 ± 19.7 vs. 63.8 ± 22.1, p = 0.011) than those without SAD. Among 87 CTD-ILD patients prospectively enrolled, significant improvement in % predicted FVC was observed at 12-months follow-up (6.37 ± 1.53, p < 0.001 in patients with SAD; 5.13 ± 1.53, p = 0.002 in patients without SAD), but not in diffusion capacity and SAD parameters. Conclusion In our cohort, about half of CTD-ILD patients have SAD, which is less frequent in smokers and more common in female patients. CTD-ILD patients with SAD have worse pulmonary function compared to those without SAD. Improvement of FVC but no improvement of SAD was observed in CTD-ILD patients after treatment.https://doi.org/10.1186/s12890-023-02381-zConnective tissue disease associated interstitial lung diseasePulmonary functionSmall airway dysfunctionTreatment response |
| spellingShingle | Linrui Xu Giacomo Sgalla Faping Wang Min Zhu Liangyuan Li Ping Li Qibing Xie Xiaoyan Lv Jianqun Yu Gang Wang Huajing Wan Luca Richeldi Fengming Luo Monitoring small airway dysfunction in connective tissue disease-related interstitial lung disease: a retrospective and prospective study BMC Pulmonary Medicine Connective tissue disease associated interstitial lung disease Pulmonary function Small airway dysfunction Treatment response |
| title | Monitoring small airway dysfunction in connective tissue disease-related interstitial lung disease: a retrospective and prospective study |
| title_full | Monitoring small airway dysfunction in connective tissue disease-related interstitial lung disease: a retrospective and prospective study |
| title_fullStr | Monitoring small airway dysfunction in connective tissue disease-related interstitial lung disease: a retrospective and prospective study |
| title_full_unstemmed | Monitoring small airway dysfunction in connective tissue disease-related interstitial lung disease: a retrospective and prospective study |
| title_short | Monitoring small airway dysfunction in connective tissue disease-related interstitial lung disease: a retrospective and prospective study |
| title_sort | monitoring small airway dysfunction in connective tissue disease related interstitial lung disease a retrospective and prospective study |
| topic | Connective tissue disease associated interstitial lung disease Pulmonary function Small airway dysfunction Treatment response |
| url | https://doi.org/10.1186/s12890-023-02381-z |
| work_keys_str_mv | AT linruixu monitoringsmallairwaydysfunctioninconnectivetissuediseaserelatedinterstitiallungdiseasearetrospectiveandprospectivestudy AT giacomosgalla monitoringsmallairwaydysfunctioninconnectivetissuediseaserelatedinterstitiallungdiseasearetrospectiveandprospectivestudy AT fapingwang monitoringsmallairwaydysfunctioninconnectivetissuediseaserelatedinterstitiallungdiseasearetrospectiveandprospectivestudy AT minzhu monitoringsmallairwaydysfunctioninconnectivetissuediseaserelatedinterstitiallungdiseasearetrospectiveandprospectivestudy AT liangyuanli monitoringsmallairwaydysfunctioninconnectivetissuediseaserelatedinterstitiallungdiseasearetrospectiveandprospectivestudy AT pingli monitoringsmallairwaydysfunctioninconnectivetissuediseaserelatedinterstitiallungdiseasearetrospectiveandprospectivestudy AT qibingxie monitoringsmallairwaydysfunctioninconnectivetissuediseaserelatedinterstitiallungdiseasearetrospectiveandprospectivestudy AT xiaoyanlv monitoringsmallairwaydysfunctioninconnectivetissuediseaserelatedinterstitiallungdiseasearetrospectiveandprospectivestudy AT jianqunyu monitoringsmallairwaydysfunctioninconnectivetissuediseaserelatedinterstitiallungdiseasearetrospectiveandprospectivestudy AT gangwang monitoringsmallairwaydysfunctioninconnectivetissuediseaserelatedinterstitiallungdiseasearetrospectiveandprospectivestudy AT huajingwan monitoringsmallairwaydysfunctioninconnectivetissuediseaserelatedinterstitiallungdiseasearetrospectiveandprospectivestudy AT lucaricheldi monitoringsmallairwaydysfunctioninconnectivetissuediseaserelatedinterstitiallungdiseasearetrospectiveandprospectivestudy AT fengmingluo monitoringsmallairwaydysfunctioninconnectivetissuediseaserelatedinterstitiallungdiseasearetrospectiveandprospectivestudy |