Altered deposition of inhaled nanoparticles in subjects with chronic obstructive pulmonary disease
Abstract Background Respiratory tract deposition of airborne particles is a key link to understand their health impact. Experimental data are limited for vulnerable groups such as individuals with respiratory diseases. The aim of this study is to investigate the differences in lung deposition of nan...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-08-01
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| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12890-018-0697-2 |
| _version_ | 1818863603937181696 |
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| author | Jonas K F Jakobsson H Laura Aaltonen Hanna Nicklasson Anders Gudmundsson Jenny Rissler Per Wollmer Jakob Löndahl |
| author_facet | Jonas K F Jakobsson H Laura Aaltonen Hanna Nicklasson Anders Gudmundsson Jenny Rissler Per Wollmer Jakob Löndahl |
| author_sort | Jonas K F Jakobsson |
| collection | DOAJ |
| description | Abstract Background Respiratory tract deposition of airborne particles is a key link to understand their health impact. Experimental data are limited for vulnerable groups such as individuals with respiratory diseases. The aim of this study is to investigate the differences in lung deposition of nanoparticles in the distal lung for healthy subjects and subjects with respiratory disease. Methods Lung deposition of nanoparticles (50 and 100 nm) was measured after a 10 s breath-hold for three groups: healthy never-smoking subjects (n = 17), asymptomatic (active and former) smokers (n = 15) and subjects with chronic obstructive pulmonary disease (n = 16). Measurements were made at 1300 mL and 1800 mL volumetric lung depth. Each subject also underwent conventional lung function tests, including post bronchodilator FEV1, VC, and diffusing capacity for carbon monoxide, DL,CO. Patients with previously diagnosed respiratory disease underwent a CT-scan of the lungs. Particle lung deposition fraction, was compared between the groups and with conventional lung function tests. Results We found that the deposition fraction was significantly lower for subjects with emphysema compared to the other subjects (p = 0.001–0.01), but no significant differences were found between healthy never-smokers and smokers. Furthermore, the particle deposition correlated with pulmonary function tests, FEV1%Pred (p < 0.05), FEV1/VC%Pred (p < 0.01) and DL,CO (p < 0.0005) when all subjects were included. Furthermore, for subjects with emphysema, deposition fraction correlated strongly with DL,CO (Pearson’s r = 0.80–0.85, p < 0.002) while this correlation was not found within the other groups. Conclusions Lower deposition fraction was observed for emphysematous subjects and this can be explained by enlarged distal airspaces in the lungs. As expected, deposition increases for smaller particles and deeper inhalation. The observed results have implications for exposure assessment of air pollution and dosimetry of aerosol-based drug delivery of nanoparticles. |
| first_indexed | 2024-12-19T10:18:24Z |
| format | Article |
| id | doaj.art-997ee24d8252451d84f46e1186f9ed26 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-19T10:18:24Z |
| publishDate | 2018-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-997ee24d8252451d84f46e1186f9ed262022-12-21T20:26:09ZengBMCBMC Pulmonary Medicine1471-24662018-08-0118111110.1186/s12890-018-0697-2Altered deposition of inhaled nanoparticles in subjects with chronic obstructive pulmonary diseaseJonas K F Jakobsson0H Laura Aaltonen1Hanna Nicklasson2Anders Gudmundsson3Jenny Rissler4Per Wollmer5Jakob Löndahl6Division of Ergonomics and Aerosol Technology, Lund UniversityDepartment of Translational Medicine, Lund UniversityDepartment of Translational Medicine, Lund UniversityDivision of Ergonomics and Aerosol Technology, Lund UniversityDivision of Ergonomics and Aerosol Technology, Lund UniversityDepartment of Translational Medicine, Lund UniversityDivision of Ergonomics and Aerosol Technology, Lund UniversityAbstract Background Respiratory tract deposition of airborne particles is a key link to understand their health impact. Experimental data are limited for vulnerable groups such as individuals with respiratory diseases. The aim of this study is to investigate the differences in lung deposition of nanoparticles in the distal lung for healthy subjects and subjects with respiratory disease. Methods Lung deposition of nanoparticles (50 and 100 nm) was measured after a 10 s breath-hold for three groups: healthy never-smoking subjects (n = 17), asymptomatic (active and former) smokers (n = 15) and subjects with chronic obstructive pulmonary disease (n = 16). Measurements were made at 1300 mL and 1800 mL volumetric lung depth. Each subject also underwent conventional lung function tests, including post bronchodilator FEV1, VC, and diffusing capacity for carbon monoxide, DL,CO. Patients with previously diagnosed respiratory disease underwent a CT-scan of the lungs. Particle lung deposition fraction, was compared between the groups and with conventional lung function tests. Results We found that the deposition fraction was significantly lower for subjects with emphysema compared to the other subjects (p = 0.001–0.01), but no significant differences were found between healthy never-smokers and smokers. Furthermore, the particle deposition correlated with pulmonary function tests, FEV1%Pred (p < 0.05), FEV1/VC%Pred (p < 0.01) and DL,CO (p < 0.0005) when all subjects were included. Furthermore, for subjects with emphysema, deposition fraction correlated strongly with DL,CO (Pearson’s r = 0.80–0.85, p < 0.002) while this correlation was not found within the other groups. Conclusions Lower deposition fraction was observed for emphysematous subjects and this can be explained by enlarged distal airspaces in the lungs. As expected, deposition increases for smaller particles and deeper inhalation. The observed results have implications for exposure assessment of air pollution and dosimetry of aerosol-based drug delivery of nanoparticles.http://link.springer.com/article/10.1186/s12890-018-0697-2Lung depositionNanoparticlesEmphysemaChronic obstructive pulmonary diseaseInhalation exposureHuman |
| spellingShingle | Jonas K F Jakobsson H Laura Aaltonen Hanna Nicklasson Anders Gudmundsson Jenny Rissler Per Wollmer Jakob Löndahl Altered deposition of inhaled nanoparticles in subjects with chronic obstructive pulmonary disease BMC Pulmonary Medicine Lung deposition Nanoparticles Emphysema Chronic obstructive pulmonary disease Inhalation exposure Human |
| title | Altered deposition of inhaled nanoparticles in subjects with chronic obstructive pulmonary disease |
| title_full | Altered deposition of inhaled nanoparticles in subjects with chronic obstructive pulmonary disease |
| title_fullStr | Altered deposition of inhaled nanoparticles in subjects with chronic obstructive pulmonary disease |
| title_full_unstemmed | Altered deposition of inhaled nanoparticles in subjects with chronic obstructive pulmonary disease |
| title_short | Altered deposition of inhaled nanoparticles in subjects with chronic obstructive pulmonary disease |
| title_sort | altered deposition of inhaled nanoparticles in subjects with chronic obstructive pulmonary disease |
| topic | Lung deposition Nanoparticles Emphysema Chronic obstructive pulmonary disease Inhalation exposure Human |
| url | http://link.springer.com/article/10.1186/s12890-018-0697-2 |
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