Symbiotic electroneural and musculoskeletal framework to encode proprioception via neurostimulation: ProprioStim
Summary: Peripheral nerve stimulation in amputees achieved the restoration of touch, but not proprioception, which is critical in locomotion. A plausible reason is the lack of means to artificially replicate the complex activity of proprioceptors. To uncover this, we coupled neuromuscular models fro...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223003255 |
| _version_ | 1811160172030066688 |
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| author | Andrea Cimolato Federico Ciotti Jelena Kljajić Giacomo Valle Stanisa Raspopovic |
| author_facet | Andrea Cimolato Federico Ciotti Jelena Kljajić Giacomo Valle Stanisa Raspopovic |
| author_sort | Andrea Cimolato |
| collection | DOAJ |
| description | Summary: Peripheral nerve stimulation in amputees achieved the restoration of touch, but not proprioception, which is critical in locomotion. A plausible reason is the lack of means to artificially replicate the complex activity of proprioceptors. To uncover this, we coupled neuromuscular models from ten subjects and nerve histologies from two implanted amputees to develop ProprioStim: a framework to encode proprioception by electrical evoking neural activity in close agreement with natural proprioceptive activity.We demonstrated its feasibility through non-invasive stimulation on seven healthy subjects comparing it with standard linear charge encoding. Results showed that ProprioStim multichannel stimulation was felt more natural, and hold promises for increasing accuracy in knee angle tracking, especially in future implantable solutions. Additionally, we quantified the importance of realistic 3D-nerve models against extruded models previously adopted for further design and validation of novel neurostimulation encoding strategies.ProprioStim provides clear guidelines for the development of neurostimulation policies restoring natural proprioception. |
| first_indexed | 2024-04-10T05:53:05Z |
| format | Article |
| id | doaj.art-997fe321a960425da8111804941c43d3 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-10T05:53:05Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-997fe321a960425da8111804941c43d32023-03-04T04:23:41ZengElsevieriScience2589-00422023-03-01263106248Symbiotic electroneural and musculoskeletal framework to encode proprioception via neurostimulation: ProprioStimAndrea Cimolato0Federico Ciotti1Jelena Kljajić2Giacomo Valle3Stanisa Raspopovic4Neuroengineering Lab, Department of Health Sciences and Technology, Institute for Robotics and Intelligent Systems, ETH Zürich, 8092 Zürich, Switzerland; Rehab Technologies Lab, Fondazione Istituto Italiano di Tecnologia, 16163 Genova, Italy; Neuroengineering and Medical Robotics Laboratory, Department of Electronics, Information and Bioengineering, Politecnico di Milano, 20133 Milan, ItalyNeuroengineering Lab, Department of Health Sciences and Technology, Institute for Robotics and Intelligent Systems, ETH Zürich, 8092 Zürich, SwitzerlandInstitute Mihajlo Pupin, Belgrade, 11060, Serbia; School of Electrical Engineering, University of Belgrade, Belgrade, 11120, SerbiaNeuroengineering Lab, Department of Health Sciences and Technology, Institute for Robotics and Intelligent Systems, ETH Zürich, 8092 Zürich, SwitzerlandNeuroengineering Lab, Department of Health Sciences and Technology, Institute for Robotics and Intelligent Systems, ETH Zürich, 8092 Zürich, Switzerland; Corresponding authorSummary: Peripheral nerve stimulation in amputees achieved the restoration of touch, but not proprioception, which is critical in locomotion. A plausible reason is the lack of means to artificially replicate the complex activity of proprioceptors. To uncover this, we coupled neuromuscular models from ten subjects and nerve histologies from two implanted amputees to develop ProprioStim: a framework to encode proprioception by electrical evoking neural activity in close agreement with natural proprioceptive activity.We demonstrated its feasibility through non-invasive stimulation on seven healthy subjects comparing it with standard linear charge encoding. Results showed that ProprioStim multichannel stimulation was felt more natural, and hold promises for increasing accuracy in knee angle tracking, especially in future implantable solutions. Additionally, we quantified the importance of realistic 3D-nerve models against extruded models previously adopted for further design and validation of novel neurostimulation encoding strategies.ProprioStim provides clear guidelines for the development of neurostimulation policies restoring natural proprioception.http://www.sciencedirect.com/science/article/pii/S2589004223003255Behavioral neuroscienceClinical neuroscienceBioelectronics |
| spellingShingle | Andrea Cimolato Federico Ciotti Jelena Kljajić Giacomo Valle Stanisa Raspopovic Symbiotic electroneural and musculoskeletal framework to encode proprioception via neurostimulation: ProprioStim iScience Behavioral neuroscience Clinical neuroscience Bioelectronics |
| title | Symbiotic electroneural and musculoskeletal framework to encode proprioception via neurostimulation: ProprioStim |
| title_full | Symbiotic electroneural and musculoskeletal framework to encode proprioception via neurostimulation: ProprioStim |
| title_fullStr | Symbiotic electroneural and musculoskeletal framework to encode proprioception via neurostimulation: ProprioStim |
| title_full_unstemmed | Symbiotic electroneural and musculoskeletal framework to encode proprioception via neurostimulation: ProprioStim |
| title_short | Symbiotic electroneural and musculoskeletal framework to encode proprioception via neurostimulation: ProprioStim |
| title_sort | symbiotic electroneural and musculoskeletal framework to encode proprioception via neurostimulation propriostim |
| topic | Behavioral neuroscience Clinical neuroscience Bioelectronics |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223003255 |
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