Targeting TGF-β-Mediated SMAD Signaling Pathway via Novel Recombinant Cytotoxin II: A Potent Protein from <i>Naja naja oxiana</i> Venom in Melanoma

Targeting TGF-β-Mediated SMAD Signaling Pathway via Novel Recombinant Cytotoxin II: A Potent Protein from <i>Naja naja oxiana</i> Venom in Melanoma

Since the current treatments have not resulted in the desired outcomes for melanoma patients, there is a need to identify more effective medications. Together with other snake venom proteins, cytotoxin-II has shown promising results in tumoral cells. In this study, recombinant cytotoxin-II (rCTII) w...

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Bibliographic Details
Main Authors: Afshin Derakhshani, Nicola Silvestris, Nima Hemmat, Zahra Asadzadeh, Mahdi Abdoli Shadbad, Niloufar Sadat Nourbakhsh, Leila Mobasheri, Parviz Vahedi, Morteza Shahmirzaie, Oronzo Brunetti, Hossein Safarpour, Behzad Baradaran
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Molecules
Subjects:
melanoma
snake venom
recombinant cytotoxin-II
TGF-β pathway
apoptosis
Online Access:https://www.mdpi.com/1420-3049/25/21/5148

Internet

https://www.mdpi.com/1420-3049/25/21/5148

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