A Green, Scalable, and Catalyst-Free One-Minute Synthesis of Quinoxalines
A highly efficient and catalyst-free protocol is reported for the synthesis of quinoxalines via the classical cyclocondensation reaction between aryldiamines and dicarbonyl compounds. Remarkably simple and green reaction conditions employing methanol as solvent afforded medium to excellent yield of...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Georg Thieme Verlag KG
2021-01-01
|
| Series: | SynOpen |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1706021 |
| _version_ | 1819061297661083648 |
|---|---|
| author | Vijayaragavan Elumalai Jørn H. Hansen |
| author_facet | Vijayaragavan Elumalai Jørn H. Hansen |
| author_sort | Vijayaragavan Elumalai |
| collection | DOAJ |
| description | A highly efficient and catalyst-free protocol is reported for the synthesis of quinoxalines via the classical cyclocondensation reaction between aryldiamines and dicarbonyl compounds. Remarkably simple and green reaction conditions employing methanol as solvent afforded medium to excellent yield of quinoxalines after only one-minute reaction time at ambient temperature. The conditions allow at least 10 gram scale synthesis of quinoxalines and should be a preferred starting point for optimization and method of choice for applications in the synthetic community. |
| first_indexed | 2024-12-21T14:40:39Z |
| format | Article |
| id | doaj.art-9981e4efce364b7ab0bf6681ce7cd7b8 |
| institution | Directory Open Access Journal |
| issn | 2509-9396 |
| language | English |
| last_indexed | 2024-12-21T14:40:39Z |
| publishDate | 2021-01-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | SynOpen |
| spelling | doaj.art-9981e4efce364b7ab0bf6681ce7cd7b82022-12-21T19:00:12ZengGeorg Thieme Verlag KGSynOpen2509-93962021-01-010501434810.1055/s-0040-1706021A Green, Scalable, and Catalyst-Free One-Minute Synthesis of QuinoxalinesVijayaragavan ElumalaiJørn H. HansenA highly efficient and catalyst-free protocol is reported for the synthesis of quinoxalines via the classical cyclocondensation reaction between aryldiamines and dicarbonyl compounds. Remarkably simple and green reaction conditions employing methanol as solvent afforded medium to excellent yield of quinoxalines after only one-minute reaction time at ambient temperature. The conditions allow at least 10 gram scale synthesis of quinoxalines and should be a preferred starting point for optimization and method of choice for applications in the synthetic community.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1706021quinoxalinediaminecondensationdiketonegreen |
| spellingShingle | Vijayaragavan Elumalai Jørn H. Hansen A Green, Scalable, and Catalyst-Free One-Minute Synthesis of Quinoxalines SynOpen quinoxaline diamine condensation diketone green |
| title | A Green, Scalable, and Catalyst-Free One-Minute Synthesis of Quinoxalines |
| title_full | A Green, Scalable, and Catalyst-Free One-Minute Synthesis of Quinoxalines |
| title_fullStr | A Green, Scalable, and Catalyst-Free One-Minute Synthesis of Quinoxalines |
| title_full_unstemmed | A Green, Scalable, and Catalyst-Free One-Minute Synthesis of Quinoxalines |
| title_short | A Green, Scalable, and Catalyst-Free One-Minute Synthesis of Quinoxalines |
| title_sort | green scalable and catalyst free one minute synthesis of quinoxalines |
| topic | quinoxaline diamine condensation diketone green |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1706021 |
| work_keys_str_mv | AT vijayaragavanelumalai agreenscalableandcatalystfreeoneminutesynthesisofquinoxalines AT jørnhhansen agreenscalableandcatalystfreeoneminutesynthesisofquinoxalines AT vijayaragavanelumalai greenscalableandcatalystfreeoneminutesynthesisofquinoxalines AT jørnhhansen greenscalableandcatalystfreeoneminutesynthesisofquinoxalines |