Therapeutic Potential of EVs: Targeting Cardiovascular Diseases
Due to their different biological functions, extracellular vesicles (EVs) have great potential from a therapeutic point of view. They are released by all cell types, carrying and delivering different kinds of biologically functional cargo. Under pathological events, cells can increase their secretio...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/11/7/1907 |
| _version_ | 1797590179277438976 |
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| author | Javier Laura Francés Christina Pagiatakis Vittoria Di Mauro Montserrat Climent |
| author_facet | Javier Laura Francés Christina Pagiatakis Vittoria Di Mauro Montserrat Climent |
| author_sort | Javier Laura Francés |
| collection | DOAJ |
| description | Due to their different biological functions, extracellular vesicles (EVs) have great potential from a therapeutic point of view. They are released by all cell types, carrying and delivering different kinds of biologically functional cargo. Under pathological events, cells can increase their secretion of EVs and can release different amounts of cargo, thus making EVs great biomarkers as indicators of pathological progression. Moreover, EVs are also known to be able to transport and deliver cargo to different recipient cells, having an important role in cellular communication. Interestingly, EVs have recently been explored as biological alternatives for the delivery of therapeutics, being considered natural drug delivery carriers. Because cardiovascular disorders (CVDs) are the leading cause of death worldwide, in this review, we will discuss the up-to-date knowledge regarding the biophysical properties and biological components of EVs, focusing on myocardial infarction, diabetic cardiomyopathy, and sepsis-induced cardiomyopathy, three very different types of CVDs. |
| first_indexed | 2024-03-11T01:16:49Z |
| format | Article |
| id | doaj.art-99841ef86a9a4321a0de438e58987d5c |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T01:16:49Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-99841ef86a9a4321a0de438e58987d5c2023-11-18T18:26:41ZengMDPI AGBiomedicines2227-90592023-07-01117190710.3390/biomedicines11071907Therapeutic Potential of EVs: Targeting Cardiovascular DiseasesJavier Laura Francés0Christina Pagiatakis1Vittoria Di Mauro2Montserrat Climent3IRCCS Humanitas Research Hospital, 20089 Rozzano, ItalyIRCCS Humanitas Research Hospital, 20089 Rozzano, ItalyIRCCS Humanitas Research Hospital, 20089 Rozzano, ItalyIRCCS Humanitas Research Hospital, 20089 Rozzano, ItalyDue to their different biological functions, extracellular vesicles (EVs) have great potential from a therapeutic point of view. They are released by all cell types, carrying and delivering different kinds of biologically functional cargo. Under pathological events, cells can increase their secretion of EVs and can release different amounts of cargo, thus making EVs great biomarkers as indicators of pathological progression. Moreover, EVs are also known to be able to transport and deliver cargo to different recipient cells, having an important role in cellular communication. Interestingly, EVs have recently been explored as biological alternatives for the delivery of therapeutics, being considered natural drug delivery carriers. Because cardiovascular disorders (CVDs) are the leading cause of death worldwide, in this review, we will discuss the up-to-date knowledge regarding the biophysical properties and biological components of EVs, focusing on myocardial infarction, diabetic cardiomyopathy, and sepsis-induced cardiomyopathy, three very different types of CVDs.https://www.mdpi.com/2227-9059/11/7/1907extracellular vesiclesexosomesEVscardiovascular diseasesmyocardial infarctiondiabetic cardiomyopathy |
| spellingShingle | Javier Laura Francés Christina Pagiatakis Vittoria Di Mauro Montserrat Climent Therapeutic Potential of EVs: Targeting Cardiovascular Diseases Biomedicines extracellular vesicles exosomes EVs cardiovascular diseases myocardial infarction diabetic cardiomyopathy |
| title | Therapeutic Potential of EVs: Targeting Cardiovascular Diseases |
| title_full | Therapeutic Potential of EVs: Targeting Cardiovascular Diseases |
| title_fullStr | Therapeutic Potential of EVs: Targeting Cardiovascular Diseases |
| title_full_unstemmed | Therapeutic Potential of EVs: Targeting Cardiovascular Diseases |
| title_short | Therapeutic Potential of EVs: Targeting Cardiovascular Diseases |
| title_sort | therapeutic potential of evs targeting cardiovascular diseases |
| topic | extracellular vesicles exosomes EVs cardiovascular diseases myocardial infarction diabetic cardiomyopathy |
| url | https://www.mdpi.com/2227-9059/11/7/1907 |
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