Bamboo Shoots Modulate Gut Microbiota, Eliminate Obesity in High-Fat-Diet-Fed Mice and Improve Lipid Metabolism
Bamboo shoots (BS) have a variety of nutritional benefits; however, their anti-obesity effect and its underlying mechanism of action are still unclear. In this study, we investigated the protective effect of BS against high-fat diet (HFD)-induced gut dysbiosis in mice. After 12 weeks of feeding C57B...
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MDPI AG
2023-03-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/12/7/1380 |
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| author | Xiaolu Zhou SolJu Pak Daotong Li Li Dong Fang Chen Xiaosong Hu Lingjun Ma |
| author_facet | Xiaolu Zhou SolJu Pak Daotong Li Li Dong Fang Chen Xiaosong Hu Lingjun Ma |
| author_sort | Xiaolu Zhou |
| collection | DOAJ |
| description | Bamboo shoots (BS) have a variety of nutritional benefits; however, their anti-obesity effect and its underlying mechanism of action are still unclear. In this study, we investigated the protective effect of BS against high-fat diet (HFD)-induced gut dysbiosis in mice. After 12 weeks of feeding C57BL/6J mice either on a normal or an HFD with or without BS, metabolic indicators, including blood lipids and glucose tolerance, were measured. <i>16S rRNA</i> gene sequencing and metabolomics were used to identify alterations in gut microbiota composition and fecal metabolic profiling. The results demonstrated that BS supplementation reduced body weight by 30.56%, mitigated liver damage, and improved insulin resistance and inflammation in obese mice. In addition, BS increased short-chain fatty acid (SCFA) levels and SCFA-producing bacteria (e.g., <i>Lachnospiraceae_NK4A136_group</i> and <i>Norank_f_Muribaculaceae</i>), and reduced levels of harmful bacteria (e.g., <i>Blautia</i> and <i>Burkholderia–Paraburkholderia</i>). Finally, BS increased many beneficial fecal metabolites, such as fatty acids and bile acids, which are highly relevant to the altered gut microbiota. Based on the modulatory effect of BS on microbiota composition and gut metabolite levels observed in this study, we suggest that BS may be beneficial in treating obesity and its related complications. |
| first_indexed | 2024-03-11T05:37:58Z |
| format | Article |
| id | doaj.art-99843915e87e41a0910b79d6b146e2ef |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-11T05:37:58Z |
| publishDate | 2023-03-01 |
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| series | Foods |
| spelling | doaj.art-99843915e87e41a0910b79d6b146e2ef2023-11-17T16:40:31ZengMDPI AGFoods2304-81582023-03-01127138010.3390/foods12071380Bamboo Shoots Modulate Gut Microbiota, Eliminate Obesity in High-Fat-Diet-Fed Mice and Improve Lipid MetabolismXiaolu Zhou0SolJu Pak1Daotong Li2Li Dong3Fang Chen4Xiaosong Hu5Lingjun Ma6National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruit and Vegetables Processing Ministry of Agriculture, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaNational Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruit and Vegetables Processing Ministry of Agriculture, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaNational Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruit and Vegetables Processing Ministry of Agriculture, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaNational Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruit and Vegetables Processing Ministry of Agriculture, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaNational Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruit and Vegetables Processing Ministry of Agriculture, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaNational Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruit and Vegetables Processing Ministry of Agriculture, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaNational Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruit and Vegetables Processing Ministry of Agriculture, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaBamboo shoots (BS) have a variety of nutritional benefits; however, their anti-obesity effect and its underlying mechanism of action are still unclear. In this study, we investigated the protective effect of BS against high-fat diet (HFD)-induced gut dysbiosis in mice. After 12 weeks of feeding C57BL/6J mice either on a normal or an HFD with or without BS, metabolic indicators, including blood lipids and glucose tolerance, were measured. <i>16S rRNA</i> gene sequencing and metabolomics were used to identify alterations in gut microbiota composition and fecal metabolic profiling. The results demonstrated that BS supplementation reduced body weight by 30.56%, mitigated liver damage, and improved insulin resistance and inflammation in obese mice. In addition, BS increased short-chain fatty acid (SCFA) levels and SCFA-producing bacteria (e.g., <i>Lachnospiraceae_NK4A136_group</i> and <i>Norank_f_Muribaculaceae</i>), and reduced levels of harmful bacteria (e.g., <i>Blautia</i> and <i>Burkholderia–Paraburkholderia</i>). Finally, BS increased many beneficial fecal metabolites, such as fatty acids and bile acids, which are highly relevant to the altered gut microbiota. Based on the modulatory effect of BS on microbiota composition and gut metabolite levels observed in this study, we suggest that BS may be beneficial in treating obesity and its related complications.https://www.mdpi.com/2304-8158/12/7/1380bamboo shootsfecal metabolomicsgut microbiotainsulin resistanceobesity |
| spellingShingle | Xiaolu Zhou SolJu Pak Daotong Li Li Dong Fang Chen Xiaosong Hu Lingjun Ma Bamboo Shoots Modulate Gut Microbiota, Eliminate Obesity in High-Fat-Diet-Fed Mice and Improve Lipid Metabolism Foods bamboo shoots fecal metabolomics gut microbiota insulin resistance obesity |
| title | Bamboo Shoots Modulate Gut Microbiota, Eliminate Obesity in High-Fat-Diet-Fed Mice and Improve Lipid Metabolism |
| title_full | Bamboo Shoots Modulate Gut Microbiota, Eliminate Obesity in High-Fat-Diet-Fed Mice and Improve Lipid Metabolism |
| title_fullStr | Bamboo Shoots Modulate Gut Microbiota, Eliminate Obesity in High-Fat-Diet-Fed Mice and Improve Lipid Metabolism |
| title_full_unstemmed | Bamboo Shoots Modulate Gut Microbiota, Eliminate Obesity in High-Fat-Diet-Fed Mice and Improve Lipid Metabolism |
| title_short | Bamboo Shoots Modulate Gut Microbiota, Eliminate Obesity in High-Fat-Diet-Fed Mice and Improve Lipid Metabolism |
| title_sort | bamboo shoots modulate gut microbiota eliminate obesity in high fat diet fed mice and improve lipid metabolism |
| topic | bamboo shoots fecal metabolomics gut microbiota insulin resistance obesity |
| url | https://www.mdpi.com/2304-8158/12/7/1380 |
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