Evaluation of choroidal thickness in prodromal Alzheimer's disease defined by amyloid PET.
<h4>Objective</h4>To assess and compare the involvement of choroidal thickness (CT) in patients with mild cognitive impairment (MCI) and dementia due to Alzheimer's disease (AD) defined by amyloid PET and healthy controls (HC).<h4>Methods</h4>Sixty-three eyes from 34 AD...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0239484 |
| _version_ | 1818843644946284544 |
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| author | Alicia López-de-Eguileta Carmen Lage Sara López-García Ana Pozueta María García-Martínez Martha Kazimierczak María Bravo María de Arcocha-Torres Ignacio Banzo Julio Jimenez-Bonilla Andrea Cerveró Alexander Goikoetxea Eloy Rodríguez-Rodríguez Pascual Sánchez-Juan Alfonso Casado |
| author_facet | Alicia López-de-Eguileta Carmen Lage Sara López-García Ana Pozueta María García-Martínez Martha Kazimierczak María Bravo María de Arcocha-Torres Ignacio Banzo Julio Jimenez-Bonilla Andrea Cerveró Alexander Goikoetxea Eloy Rodríguez-Rodríguez Pascual Sánchez-Juan Alfonso Casado |
| author_sort | Alicia López-de-Eguileta |
| collection | DOAJ |
| description | <h4>Objective</h4>To assess and compare the involvement of choroidal thickness (CT) in patients with mild cognitive impairment (MCI) and dementia due to Alzheimer's disease (AD) defined by amyloid PET and healthy controls (HC).<h4>Methods</h4>Sixty-three eyes from 34 AD patients [12 eyes (19.0%) with dementia and 51 eyes (80.9%) with MCI], positive to 11C-labelled Pittsburgh Compound-B with positron emission tomography (11C-PiB PET/CT), and the same number of sex- and age-paired HC were recruited. All participants underwent enhanced depth imaging optical coherence tomography (EDI-OCT) assessing CT at 14 measurements from 2 B-scans. Paired Student t-test was used to compare CT measurements between MCI, dementia and sex- and age-paired HC. A univariate generalized estimating equations model (GEE) test was performed to compare MCI and dementia individually with all HC included.<h4>Results</h4>Compared with HC, eyes from patients with positive 11C-PiB PET/CT showed a significant CT thinning in 5 selected locations (in foveal thickness in vertical scan, in temporal scan at 1500μm, in superior scan at 500μm and in inferior scan at 1000μm and 1500μm, p = 0.020-0.045) whilst few significant CT reduction data was reported in MCI or dementia individually versus HC. However, the GEE test identified significant CT thinning in AD compared with all HC included (p = 0.015-0.046).<h4>Conclusions</h4>To our knowledge, the present study is the first measuring CT in eyes from MCI and dementia eyes positive to 11C-PiB PET/CT reporting a significant trend towards CT thinning in MCI patients which became more pronounced in dementia stage. We support further investigation involving larger and prospective OCT studies in AD population characterized with available biomarkers to describe whether choroidal vascular damage occurs specifically in prodromal stages of AD. |
| first_indexed | 2024-12-19T05:01:09Z |
| format | Article |
| id | doaj.art-9984609b82974139a7caea3cf935ab1b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T05:01:09Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-9984609b82974139a7caea3cf935ab1b2022-12-21T20:35:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01159e023948410.1371/journal.pone.0239484Evaluation of choroidal thickness in prodromal Alzheimer's disease defined by amyloid PET.Alicia López-de-EguiletaCarmen LageSara López-GarcíaAna PozuetaMaría García-MartínezMartha KazimierczakMaría BravoMaría de Arcocha-TorresIgnacio BanzoJulio Jimenez-BonillaAndrea CerveróAlexander GoikoetxeaEloy Rodríguez-RodríguezPascual Sánchez-JuanAlfonso Casado<h4>Objective</h4>To assess and compare the involvement of choroidal thickness (CT) in patients with mild cognitive impairment (MCI) and dementia due to Alzheimer's disease (AD) defined by amyloid PET and healthy controls (HC).<h4>Methods</h4>Sixty-three eyes from 34 AD patients [12 eyes (19.0%) with dementia and 51 eyes (80.9%) with MCI], positive to 11C-labelled Pittsburgh Compound-B with positron emission tomography (11C-PiB PET/CT), and the same number of sex- and age-paired HC were recruited. All participants underwent enhanced depth imaging optical coherence tomography (EDI-OCT) assessing CT at 14 measurements from 2 B-scans. Paired Student t-test was used to compare CT measurements between MCI, dementia and sex- and age-paired HC. A univariate generalized estimating equations model (GEE) test was performed to compare MCI and dementia individually with all HC included.<h4>Results</h4>Compared with HC, eyes from patients with positive 11C-PiB PET/CT showed a significant CT thinning in 5 selected locations (in foveal thickness in vertical scan, in temporal scan at 1500μm, in superior scan at 500μm and in inferior scan at 1000μm and 1500μm, p = 0.020-0.045) whilst few significant CT reduction data was reported in MCI or dementia individually versus HC. However, the GEE test identified significant CT thinning in AD compared with all HC included (p = 0.015-0.046).<h4>Conclusions</h4>To our knowledge, the present study is the first measuring CT in eyes from MCI and dementia eyes positive to 11C-PiB PET/CT reporting a significant trend towards CT thinning in MCI patients which became more pronounced in dementia stage. We support further investigation involving larger and prospective OCT studies in AD population characterized with available biomarkers to describe whether choroidal vascular damage occurs specifically in prodromal stages of AD.https://doi.org/10.1371/journal.pone.0239484 |
| spellingShingle | Alicia López-de-Eguileta Carmen Lage Sara López-García Ana Pozueta María García-Martínez Martha Kazimierczak María Bravo María de Arcocha-Torres Ignacio Banzo Julio Jimenez-Bonilla Andrea Cerveró Alexander Goikoetxea Eloy Rodríguez-Rodríguez Pascual Sánchez-Juan Alfonso Casado Evaluation of choroidal thickness in prodromal Alzheimer's disease defined by amyloid PET. PLoS ONE |
| title | Evaluation of choroidal thickness in prodromal Alzheimer's disease defined by amyloid PET. |
| title_full | Evaluation of choroidal thickness in prodromal Alzheimer's disease defined by amyloid PET. |
| title_fullStr | Evaluation of choroidal thickness in prodromal Alzheimer's disease defined by amyloid PET. |
| title_full_unstemmed | Evaluation of choroidal thickness in prodromal Alzheimer's disease defined by amyloid PET. |
| title_short | Evaluation of choroidal thickness in prodromal Alzheimer's disease defined by amyloid PET. |
| title_sort | evaluation of choroidal thickness in prodromal alzheimer s disease defined by amyloid pet |
| url | https://doi.org/10.1371/journal.pone.0239484 |
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