C60 Fullerene Effects on Diphenyl-N-(trichloroacetyl)-amidophosphate Interaction with DNA In Silico and Its Cytotoxic Activity Against Human Leukemic Cell Line In Vitro

C60 Fullerene Effects on Diphenyl-N-(trichloroacetyl)-amidophosphate Interaction with DNA In Silico and Its Cytotoxic Activity Against Human Leukemic Cell Line In Vitro

Abstract New representative of carbacylamidophosphates - diphenyl-N-(trichloroacetyl)-amidophosphate (HL), which contains two phenoxy substituents near the phosphoryl group, was synthesized, identified by elemental analysis and IR and NMR spectroscopy, and tested as a cytotoxic agent itself and in c...

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Bibliographic Details
Main Authors: A. Grebinyk, S. Prylutska, I. Grynyuk, B. Kolp, V. Hurmach, T. Sliva, V. Amirkhanov, V. Trush, O. Matyshevska, M. Slobodyanik, Yu. Prylutskyy, M. Frohme, U. Ritter
Format: Article
Language:English
Published: SpringerOpen 2018-03-01
Series:Nanoscale Research Letters
Subjects:
Diphenyl-N-(trichloroacetyl)-amidophosphate (HL)
C60 fullerene
Leukemic CCRF-CEM cells
DNA
Molecular simulation
Online Access:http://link.springer.com/article/10.1186/s11671-018-2490-9

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