Epithelial protein lost in neoplasm (EPLIN): Beyond a tumor suppressor
The majority of cancer-related deaths are caused by tumor recurrence, metastasis and therapeutic resistance. During the late stages of tumor progression, multiple factors are involved, including the downregulation and/or loss of function of metastasis suppressors. Epithelial protein lost in neoplasm...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2017-06-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304217300259 |
| _version_ | 1797719580627435520 |
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| author | Daqing Wu |
| author_facet | Daqing Wu |
| author_sort | Daqing Wu |
| collection | DOAJ |
| description | The majority of cancer-related deaths are caused by tumor recurrence, metastasis and therapeutic resistance. During the late stages of tumor progression, multiple factors are involved, including the downregulation and/or loss of function of metastasis suppressors. Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, was initially identified as a putative tumor suppressor that is frequently downregulated in epithelial tumors. Recent evidence indicates that EPLIN may negatively regulate epithelia-to-mesenchymal transition (EMT), a crucial process by which cancer cells acquire invasive capabilities and therapeutic resistance. Importantly, downregulation of EPLIN is associated with clinical metastasis in a variety of solid tumors, suggesting that EPLIN could be a suppressor of metastasis. In this review, I will discuss the regulation and function of EPLIN in human cancer cells and explore the clinical significance of EPLIN in metastatic disease. |
| first_indexed | 2024-03-12T09:06:57Z |
| format | Article |
| id | doaj.art-9986ffd490164830b14e9fc873ec11e7 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T09:06:57Z |
| publishDate | 2017-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-9986ffd490164830b14e9fc873ec11e72023-09-02T15:15:13ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422017-06-014210010710.1016/j.gendis.2017.03.002Epithelial protein lost in neoplasm (EPLIN): Beyond a tumor suppressorDaqing Wu0Georgia Cancer Center and Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, USAThe majority of cancer-related deaths are caused by tumor recurrence, metastasis and therapeutic resistance. During the late stages of tumor progression, multiple factors are involved, including the downregulation and/or loss of function of metastasis suppressors. Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, was initially identified as a putative tumor suppressor that is frequently downregulated in epithelial tumors. Recent evidence indicates that EPLIN may negatively regulate epithelia-to-mesenchymal transition (EMT), a crucial process by which cancer cells acquire invasive capabilities and therapeutic resistance. Importantly, downregulation of EPLIN is associated with clinical metastasis in a variety of solid tumors, suggesting that EPLIN could be a suppressor of metastasis. In this review, I will discuss the regulation and function of EPLIN in human cancer cells and explore the clinical significance of EPLIN in metastatic disease.http://www.sciencedirect.com/science/article/pii/S2352304217300259Actin cytoskeletonChemoresistanceEpithelial-to-mesenchymal transitionEPLINMetastasis suppressorTumor suppressor |
| spellingShingle | Daqing Wu Epithelial protein lost in neoplasm (EPLIN): Beyond a tumor suppressor Genes and Diseases Actin cytoskeleton Chemoresistance Epithelial-to-mesenchymal transition EPLIN Metastasis suppressor Tumor suppressor |
| title | Epithelial protein lost in neoplasm (EPLIN): Beyond a tumor suppressor |
| title_full | Epithelial protein lost in neoplasm (EPLIN): Beyond a tumor suppressor |
| title_fullStr | Epithelial protein lost in neoplasm (EPLIN): Beyond a tumor suppressor |
| title_full_unstemmed | Epithelial protein lost in neoplasm (EPLIN): Beyond a tumor suppressor |
| title_short | Epithelial protein lost in neoplasm (EPLIN): Beyond a tumor suppressor |
| title_sort | epithelial protein lost in neoplasm eplin beyond a tumor suppressor |
| topic | Actin cytoskeleton Chemoresistance Epithelial-to-mesenchymal transition EPLIN Metastasis suppressor Tumor suppressor |
| url | http://www.sciencedirect.com/science/article/pii/S2352304217300259 |
| work_keys_str_mv | AT daqingwu epithelialproteinlostinneoplasmeplinbeyondatumorsuppressor |