A Comparison of the Correlation of Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) with Health-Related Quality of Life
Background and Aim: The aim of this study was to compare the correlation of a recently developed systemic lupus erythematosus disease activity score (SLE-DAS) with the SLE disease activity index 2000 (SLEDAI-2K) with the Lupus Quality of Life questionnaire (LupusQoL) in Taiwanese patients with SLE....
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/10/10/2137 |
| _version_ | 1797533963880759296 |
|---|---|
| author | Ning-Sheng Lai Ming-Chi Lu Hsiu-Hua Chang Hui-Chin Lo Chia-Wen Hsu Kuang-Yung Huang Chien-Hsueh Tung Bao-Bao Hsu Cheng-Han Wu Malcolm Koo |
| author_facet | Ning-Sheng Lai Ming-Chi Lu Hsiu-Hua Chang Hui-Chin Lo Chia-Wen Hsu Kuang-Yung Huang Chien-Hsueh Tung Bao-Bao Hsu Cheng-Han Wu Malcolm Koo |
| author_sort | Ning-Sheng Lai |
| collection | DOAJ |
| description | Background and Aim: The aim of this study was to compare the correlation of a recently developed systemic lupus erythematosus disease activity score (SLE-DAS) with the SLE disease activity index 2000 (SLEDAI-2K) with the Lupus Quality of Life questionnaire (LupusQoL) in Taiwanese patients with SLE. Methods: A cross-sectional study was conducted in a regional teaching hospital in Taiwan from April to August 2019. Adult patients with a clinician-confirmed diagnosis of SLE based on the 1997 American College of Rheumatology revised criteria or the 2012 Systemic Lupus International Collaborating Clinics Classification Criteria were recruited. SLE disease activity was measured with both SLEDAI-2K and SLE-DAS. Disease-specific quality of life was assessed using the LupusQoL. Results: Of the 333 patients with SLE in this study, 90.4% were female and 40% were between the ages of 20 and 39 years. The median SLEDAI-2K score was 4.00 (interquartile range [IQR] 2.00–7.50) and the median SLE-DAS score was 2.08 (IQR 1.12–8.24) in our patients with SLE. After adjusting for sex and age intervals, both SLEDAI-2k and SLE-DAS were significantly and inversely associated with all eight domains of LupusQoL. The magnitudes of the mean absolute error, root mean square error, Akaike Information Criterion, Bayesian Information Criterion, and coefficient of determination were comparable between SLEDAI-2K and SLE-DAS. Conclusions: There were no clear differences in the use of SLE-DAS over SLEDAI-2K in assessing HRQoL in patients with SLE. We suggest that, in this aspect, both SLEDAI-2K and SLE-DAS are effective tools for measuring disease activity in patients with SLE. |
| first_indexed | 2024-03-10T11:23:07Z |
| format | Article |
| id | doaj.art-9989c677a227404d984e5ee10c88e0a4 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T11:23:07Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-9989c677a227404d984e5ee10c88e0a42023-11-21T19:51:46ZengMDPI AGJournal of Clinical Medicine2077-03832021-05-011010213710.3390/jcm10102137A Comparison of the Correlation of Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) with Health-Related Quality of LifeNing-Sheng Lai0Ming-Chi Lu1Hsiu-Hua Chang2Hui-Chin Lo3Chia-Wen Hsu4Kuang-Yung Huang5Chien-Hsueh Tung6Bao-Bao Hsu7Cheng-Han Wu8Malcolm Koo9Division of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi 622401, TaiwanDivision of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi 622401, TaiwanDepartment of Medical Research, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi 622401, TaiwanDepartment of Medical Research, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi 622401, TaiwanDepartment of Medical Research, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi 622401, TaiwanDivision of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi 622401, TaiwanDivision of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi 622401, TaiwanDivision of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi 622401, TaiwanDivision of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi 622401, TaiwanGraduate Institute of Long-Term Care, Tzu Chi University of Science and Technology, Hualien City, Hualien 973302, TaiwanBackground and Aim: The aim of this study was to compare the correlation of a recently developed systemic lupus erythematosus disease activity score (SLE-DAS) with the SLE disease activity index 2000 (SLEDAI-2K) with the Lupus Quality of Life questionnaire (LupusQoL) in Taiwanese patients with SLE. Methods: A cross-sectional study was conducted in a regional teaching hospital in Taiwan from April to August 2019. Adult patients with a clinician-confirmed diagnosis of SLE based on the 1997 American College of Rheumatology revised criteria or the 2012 Systemic Lupus International Collaborating Clinics Classification Criteria were recruited. SLE disease activity was measured with both SLEDAI-2K and SLE-DAS. Disease-specific quality of life was assessed using the LupusQoL. Results: Of the 333 patients with SLE in this study, 90.4% were female and 40% were between the ages of 20 and 39 years. The median SLEDAI-2K score was 4.00 (interquartile range [IQR] 2.00–7.50) and the median SLE-DAS score was 2.08 (IQR 1.12–8.24) in our patients with SLE. After adjusting for sex and age intervals, both SLEDAI-2k and SLE-DAS were significantly and inversely associated with all eight domains of LupusQoL. The magnitudes of the mean absolute error, root mean square error, Akaike Information Criterion, Bayesian Information Criterion, and coefficient of determination were comparable between SLEDAI-2K and SLE-DAS. Conclusions: There were no clear differences in the use of SLE-DAS over SLEDAI-2K in assessing HRQoL in patients with SLE. We suggest that, in this aspect, both SLEDAI-2K and SLE-DAS are effective tools for measuring disease activity in patients with SLE.https://www.mdpi.com/2077-0383/10/10/2137systemic lupus erythematosusquality of lifecross-sectional studiessurveys and questionnaires |
| spellingShingle | Ning-Sheng Lai Ming-Chi Lu Hsiu-Hua Chang Hui-Chin Lo Chia-Wen Hsu Kuang-Yung Huang Chien-Hsueh Tung Bao-Bao Hsu Cheng-Han Wu Malcolm Koo A Comparison of the Correlation of Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) with Health-Related Quality of Life Journal of Clinical Medicine systemic lupus erythematosus quality of life cross-sectional studies surveys and questionnaires |
| title | A Comparison of the Correlation of Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) with Health-Related Quality of Life |
| title_full | A Comparison of the Correlation of Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) with Health-Related Quality of Life |
| title_fullStr | A Comparison of the Correlation of Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) with Health-Related Quality of Life |
| title_full_unstemmed | A Comparison of the Correlation of Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) with Health-Related Quality of Life |
| title_short | A Comparison of the Correlation of Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) with Health-Related Quality of Life |
| title_sort | comparison of the correlation of systemic lupus erythematosus disease activity index 2000 sledai 2k and systemic lupus erythematosus disease activity score sle das with health related quality of life |
| topic | systemic lupus erythematosus quality of life cross-sectional studies surveys and questionnaires |
| url | https://www.mdpi.com/2077-0383/10/10/2137 |
| work_keys_str_mv | AT ningshenglai acomparisonofthecorrelationofsystemiclupuserythematosusdiseaseactivityindex2000sledai2kandsystemiclupuserythematosusdiseaseactivityscoresledaswithhealthrelatedqualityoflife AT mingchilu acomparisonofthecorrelationofsystemiclupuserythematosusdiseaseactivityindex2000sledai2kandsystemiclupuserythematosusdiseaseactivityscoresledaswithhealthrelatedqualityoflife AT hsiuhuachang acomparisonofthecorrelationofsystemiclupuserythematosusdiseaseactivityindex2000sledai2kandsystemiclupuserythematosusdiseaseactivityscoresledaswithhealthrelatedqualityoflife AT huichinlo acomparisonofthecorrelationofsystemiclupuserythematosusdiseaseactivityindex2000sledai2kandsystemiclupuserythematosusdiseaseactivityscoresledaswithhealthrelatedqualityoflife AT chiawenhsu acomparisonofthecorrelationofsystemiclupuserythematosusdiseaseactivityindex2000sledai2kandsystemiclupuserythematosusdiseaseactivityscoresledaswithhealthrelatedqualityoflife AT kuangyunghuang acomparisonofthecorrelationofsystemiclupuserythematosusdiseaseactivityindex2000sledai2kandsystemiclupuserythematosusdiseaseactivityscoresledaswithhealthrelatedqualityoflife AT chienhsuehtung acomparisonofthecorrelationofsystemiclupuserythematosusdiseaseactivityindex2000sledai2kandsystemiclupuserythematosusdiseaseactivityscoresledaswithhealthrelatedqualityoflife AT baobaohsu acomparisonofthecorrelationofsystemiclupuserythematosusdiseaseactivityindex2000sledai2kandsystemiclupuserythematosusdiseaseactivityscoresledaswithhealthrelatedqualityoflife AT chenghanwu acomparisonofthecorrelationofsystemiclupuserythematosusdiseaseactivityindex2000sledai2kandsystemiclupuserythematosusdiseaseactivityscoresledaswithhealthrelatedqualityoflife AT malcolmkoo acomparisonofthecorrelationofsystemiclupuserythematosusdiseaseactivityindex2000sledai2kandsystemiclupuserythematosusdiseaseactivityscoresledaswithhealthrelatedqualityoflife AT ningshenglai comparisonofthecorrelationofsystemiclupuserythematosusdiseaseactivityindex2000sledai2kandsystemiclupuserythematosusdiseaseactivityscoresledaswithhealthrelatedqualityoflife AT mingchilu comparisonofthecorrelationofsystemiclupuserythematosusdiseaseactivityindex2000sledai2kandsystemiclupuserythematosusdiseaseactivityscoresledaswithhealthrelatedqualityoflife AT hsiuhuachang comparisonofthecorrelationofsystemiclupuserythematosusdiseaseactivityindex2000sledai2kandsystemiclupuserythematosusdiseaseactivityscoresledaswithhealthrelatedqualityoflife AT huichinlo comparisonofthecorrelationofsystemiclupuserythematosusdiseaseactivityindex2000sledai2kandsystemiclupuserythematosusdiseaseactivityscoresledaswithhealthrelatedqualityoflife AT chiawenhsu comparisonofthecorrelationofsystemiclupuserythematosusdiseaseactivityindex2000sledai2kandsystemiclupuserythematosusdiseaseactivityscoresledaswithhealthrelatedqualityoflife AT kuangyunghuang comparisonofthecorrelationofsystemiclupuserythematosusdiseaseactivityindex2000sledai2kandsystemiclupuserythematosusdiseaseactivityscoresledaswithhealthrelatedqualityoflife AT chienhsuehtung comparisonofthecorrelationofsystemiclupuserythematosusdiseaseactivityindex2000sledai2kandsystemiclupuserythematosusdiseaseactivityscoresledaswithhealthrelatedqualityoflife AT baobaohsu comparisonofthecorrelationofsystemiclupuserythematosusdiseaseactivityindex2000sledai2kandsystemiclupuserythematosusdiseaseactivityscoresledaswithhealthrelatedqualityoflife AT chenghanwu comparisonofthecorrelationofsystemiclupuserythematosusdiseaseactivityindex2000sledai2kandsystemiclupuserythematosusdiseaseactivityscoresledaswithhealthrelatedqualityoflife AT malcolmkoo comparisonofthecorrelationofsystemiclupuserythematosusdiseaseactivityindex2000sledai2kandsystemiclupuserythematosusdiseaseactivityscoresledaswithhealthrelatedqualityoflife |