Is there a rationale for supplementing with vitamin D patients under treatment with allergen immunotherapy?
AbstractVitamin D (VD) has been shown to exert immunomodulatory activities, especially in promoting immune tolerance. For these properties VD has been proposed in the therapy of immunological conditions in which the loss of tolerance is the key pathogenetic aspect of the disease, such as allergies....
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2023.2230864 |
| _version_ | 1827380548618682368 |
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| author | Mario Di Gioacchino Claudia Petrarca Loredana Della Valle Rocco Mangifesta Francesca Santilli |
| author_facet | Mario Di Gioacchino Claudia Petrarca Loredana Della Valle Rocco Mangifesta Francesca Santilli |
| author_sort | Mario Di Gioacchino |
| collection | DOAJ |
| description | AbstractVitamin D (VD) has been shown to exert immunomodulatory activities, especially in promoting immune tolerance. For these properties VD has been proposed in the therapy of immunological conditions in which the loss of tolerance is the key pathogenetic aspect of the disease, such as allergies. Despite these properties available literature suggests VD is not useful in treating or preventing allergic diseases and whether low serum VD levels favor allergic sensitization and severity is debated. The level of VD is one of the many conditions that can influence allergic sensitization and therefore only a multivariate analysis on a numerically adequate cohort of patients, that considers all the factors that can favor allergy, would be able to assign the weight of each variable and determine the extent to which VD inhibits allergic sensitization and march. On the contrary, VD is able to potentiate the antigen-specific tolerogenic response induced by Allergen Immunotherapy (AIT) as demonstrated by the large majority of studies. In our experience, the association of VD and Sublingual AIT (LAIS, Lofarma, Italy) gave an excellent clinical and immune response in particular enhancing the differentiation of memory T regulatory cells. While waiting for a more extensive literature, VD/AIT combination should be always performed in treating allergies. In any case, the assessment of the level of VD should become a routine in allergic patients with an indication to AIT as, in case of VD deficiency or insufficiency, VD seems a particularly active adjuvant to the immune treatment. |
| first_indexed | 2024-03-08T13:35:33Z |
| format | Article |
| id | doaj.art-998ab8c60301445b99c77a48194b6001 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T13:35:33Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-998ab8c60301445b99c77a48194b60012024-01-16T19:13:21ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602023-12-0155110.1080/07853890.2023.2230864Is there a rationale for supplementing with vitamin D patients under treatment with allergen immunotherapy?Mario Di Gioacchino0Claudia Petrarca1Loredana Della Valle2Rocco Mangifesta3Francesca Santilli4Institute for Clinical Immunotherapy and Advanced Biological Treatments, Pescara, ItalyCenter for Advanced Science and Technology (CAST), G. d’Annunzio University, Chieti, ItalyPneumology Division, University Hospital, Chieti, ItalyCenter for Advanced Science and Technology (CAST), G. d’Annunzio University, Chieti, ItalyCenter for Advanced Science and Technology (CAST), G. d’Annunzio University, Chieti, ItalyAbstractVitamin D (VD) has been shown to exert immunomodulatory activities, especially in promoting immune tolerance. For these properties VD has been proposed in the therapy of immunological conditions in which the loss of tolerance is the key pathogenetic aspect of the disease, such as allergies. Despite these properties available literature suggests VD is not useful in treating or preventing allergic diseases and whether low serum VD levels favor allergic sensitization and severity is debated. The level of VD is one of the many conditions that can influence allergic sensitization and therefore only a multivariate analysis on a numerically adequate cohort of patients, that considers all the factors that can favor allergy, would be able to assign the weight of each variable and determine the extent to which VD inhibits allergic sensitization and march. On the contrary, VD is able to potentiate the antigen-specific tolerogenic response induced by Allergen Immunotherapy (AIT) as demonstrated by the large majority of studies. In our experience, the association of VD and Sublingual AIT (LAIS, Lofarma, Italy) gave an excellent clinical and immune response in particular enhancing the differentiation of memory T regulatory cells. While waiting for a more extensive literature, VD/AIT combination should be always performed in treating allergies. In any case, the assessment of the level of VD should become a routine in allergic patients with an indication to AIT as, in case of VD deficiency or insufficiency, VD seems a particularly active adjuvant to the immune treatment.https://www.tandfonline.com/doi/10.1080/07853890.2023.2230864Vitamin Dallergymonomeric allergoidallergen immunotherapyadjuvantrhinitis |
| spellingShingle | Mario Di Gioacchino Claudia Petrarca Loredana Della Valle Rocco Mangifesta Francesca Santilli Is there a rationale for supplementing with vitamin D patients under treatment with allergen immunotherapy? Annals of Medicine Vitamin D allergy monomeric allergoid allergen immunotherapy adjuvant rhinitis |
| title | Is there a rationale for supplementing with vitamin D patients under treatment with allergen immunotherapy? |
| title_full | Is there a rationale for supplementing with vitamin D patients under treatment with allergen immunotherapy? |
| title_fullStr | Is there a rationale for supplementing with vitamin D patients under treatment with allergen immunotherapy? |
| title_full_unstemmed | Is there a rationale for supplementing with vitamin D patients under treatment with allergen immunotherapy? |
| title_short | Is there a rationale for supplementing with vitamin D patients under treatment with allergen immunotherapy? |
| title_sort | is there a rationale for supplementing with vitamin d patients under treatment with allergen immunotherapy |
| topic | Vitamin D allergy monomeric allergoid allergen immunotherapy adjuvant rhinitis |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2023.2230864 |
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