The role of induced sputum in the diagnosis of pulmonary tuberculosis
Background: Microbiological confirmation of pulmonary tuberculosis (TB) is of paramount importance in the era of immunocompromised host and emergence of multi-drug resistance. Objectives: To assess the value of sputum induction (SI) with hypertonic saline nebulization as a diagnostic tool in patient...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Lung India |
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| Online Access: | http://www.lungindia.com/article.asp?issn=0970-2113;year=2013;volume=30;issue=3;spage=199;epage=202;aulast=Biswas |
| _version_ | 1798044195780296704 |
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| author | Saurabh Biswas Anirban Das Arijit Sinha Sibes K Das Tapan Das Bairagya |
| author_facet | Saurabh Biswas Anirban Das Arijit Sinha Sibes K Das Tapan Das Bairagya |
| author_sort | Saurabh Biswas |
| collection | DOAJ |
| description | Background: Microbiological confirmation of pulmonary tuberculosis (TB) is of paramount importance in the era of immunocompromised host and emergence of multi-drug resistance. Objectives: To assess the value of sputum induction (SI) with hypertonic saline nebulization as a diagnostic tool in patients with suspected pulmonary TB who have no/inadequate sputum or have a sputum smear negative for acid fast bacillus (AFB). Materials and Methods: One hundred patients with clinical and radiological evidence of pulmonary TB with no/inadequate sputum or smear negative with spontaneous sputum were studied. Sputum was induced with 20 mL of 3% hypertonic saline solution delivered through ultrasonic nebulizer. The specimens were subjected to Ziehl Neelsen staining and were examined under oil immersion lens for the presence of AFB. The specimens were also subjected to mycobacterial culture in BACTEC 460 TB system. Results: Ninety five patients could produce adequate sputum after SI. Sputum from thirty two patients were found to be positive both in smear and culture while sputum from another three patients were smear negative, but culture positive. Conclusion: SI is a safe, cheap and non-invasive procedure and provides significant yield in the diagnosis of pulmonary TB; thus, increasing the case detection rate of smear positive pulmonary TB. |
| first_indexed | 2024-04-11T22:59:36Z |
| format | Article |
| id | doaj.art-998b6e884a27439691bf779c8ee20e3c |
| institution | Directory Open Access Journal |
| issn | 0970-2113 0974-598X |
| language | English |
| last_indexed | 2024-04-11T22:59:36Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Lung India |
| spelling | doaj.art-998b6e884a27439691bf779c8ee20e3c2022-12-22T03:58:13ZengWolters Kluwer Medknow PublicationsLung India0970-21130974-598X2013-01-0130319920210.4103/0970-2113.116259The role of induced sputum in the diagnosis of pulmonary tuberculosisSaurabh BiswasAnirban DasArijit SinhaSibes K DasTapan Das BairagyaBackground: Microbiological confirmation of pulmonary tuberculosis (TB) is of paramount importance in the era of immunocompromised host and emergence of multi-drug resistance. Objectives: To assess the value of sputum induction (SI) with hypertonic saline nebulization as a diagnostic tool in patients with suspected pulmonary TB who have no/inadequate sputum or have a sputum smear negative for acid fast bacillus (AFB). Materials and Methods: One hundred patients with clinical and radiological evidence of pulmonary TB with no/inadequate sputum or smear negative with spontaneous sputum were studied. Sputum was induced with 20 mL of 3% hypertonic saline solution delivered through ultrasonic nebulizer. The specimens were subjected to Ziehl Neelsen staining and were examined under oil immersion lens for the presence of AFB. The specimens were also subjected to mycobacterial culture in BACTEC 460 TB system. Results: Ninety five patients could produce adequate sputum after SI. Sputum from thirty two patients were found to be positive both in smear and culture while sputum from another three patients were smear negative, but culture positive. Conclusion: SI is a safe, cheap and non-invasive procedure and provides significant yield in the diagnosis of pulmonary TB; thus, increasing the case detection rate of smear positive pulmonary TB.http://www.lungindia.com/article.asp?issn=0970-2113;year=2013;volume=30;issue=3;spage=199;epage=202;aulast=BiswasInduced sputumpulmonary tuberculosissputum smear negative |
| spellingShingle | Saurabh Biswas Anirban Das Arijit Sinha Sibes K Das Tapan Das Bairagya The role of induced sputum in the diagnosis of pulmonary tuberculosis Lung India Induced sputum pulmonary tuberculosis sputum smear negative |
| title | The role of induced sputum in the diagnosis of pulmonary tuberculosis |
| title_full | The role of induced sputum in the diagnosis of pulmonary tuberculosis |
| title_fullStr | The role of induced sputum in the diagnosis of pulmonary tuberculosis |
| title_full_unstemmed | The role of induced sputum in the diagnosis of pulmonary tuberculosis |
| title_short | The role of induced sputum in the diagnosis of pulmonary tuberculosis |
| title_sort | role of induced sputum in the diagnosis of pulmonary tuberculosis |
| topic | Induced sputum pulmonary tuberculosis sputum smear negative |
| url | http://www.lungindia.com/article.asp?issn=0970-2113;year=2013;volume=30;issue=3;spage=199;epage=202;aulast=Biswas |
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