Connecting DCX, COMT and FMR1 in social behavior and cognitive impairment
Abstract Genetic variants of DCX, COMT and FMR1 have been linked to neurodevelopmental disorders related to intellectual disability and social behavior. In this systematic review we examine the roles of the DCX, COMT and FMR1 genes in the context of hippocampal neurogenesis with respect to these dis...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | Behavioral and Brain Functions |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12993-022-00191-7 |
| _version_ | 1811250865444487168 |
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| author | Anna Delprato Emily Xiao Devika Manoj |
| author_facet | Anna Delprato Emily Xiao Devika Manoj |
| author_sort | Anna Delprato |
| collection | DOAJ |
| description | Abstract Genetic variants of DCX, COMT and FMR1 have been linked to neurodevelopmental disorders related to intellectual disability and social behavior. In this systematic review we examine the roles of the DCX, COMT and FMR1 genes in the context of hippocampal neurogenesis with respect to these disorders with the aim of identifying important hubs and signaling pathways that may bridge these conditions. Taken together our findings indicate that factors connecting DCX, COMT, and FMR1 in intellectual disability and social behavior may converge at Wnt signaling, neuron migration, and axon and dendrite morphogenesis. Data derived from genomic research has identified a multitude of genes that are linked to brain disorders and developmental differences. Information about where and how these genes function and cooperate is lagging behind. The approach used here may help to shed light on the biological underpinnings in which key genes interface and may prove useful for the testing of specific hypotheses. |
| first_indexed | 2024-04-12T16:11:09Z |
| format | Article |
| id | doaj.art-998ca5456a0e4830ae935f5cba3c907c |
| institution | Directory Open Access Journal |
| issn | 1744-9081 |
| language | English |
| last_indexed | 2024-04-12T16:11:09Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Behavioral and Brain Functions |
| spelling | doaj.art-998ca5456a0e4830ae935f5cba3c907c2022-12-22T03:25:54ZengBMCBehavioral and Brain Functions1744-90812022-05-0118111110.1186/s12993-022-00191-7Connecting DCX, COMT and FMR1 in social behavior and cognitive impairmentAnna Delprato0Emily Xiao1Devika Manoj2Department of Research and Education, BioScience ProjectDepartment of Research and Education, BioScience ProjectDepartment of Research and Education, BioScience ProjectAbstract Genetic variants of DCX, COMT and FMR1 have been linked to neurodevelopmental disorders related to intellectual disability and social behavior. In this systematic review we examine the roles of the DCX, COMT and FMR1 genes in the context of hippocampal neurogenesis with respect to these disorders with the aim of identifying important hubs and signaling pathways that may bridge these conditions. Taken together our findings indicate that factors connecting DCX, COMT, and FMR1 in intellectual disability and social behavior may converge at Wnt signaling, neuron migration, and axon and dendrite morphogenesis. Data derived from genomic research has identified a multitude of genes that are linked to brain disorders and developmental differences. Information about where and how these genes function and cooperate is lagging behind. The approach used here may help to shed light on the biological underpinnings in which key genes interface and may prove useful for the testing of specific hypotheses.https://doi.org/10.1186/s12993-022-00191-7Intellectual disabilitySocial behaviorNeurogenesisHippocampusWnt signalingCOMT |
| spellingShingle | Anna Delprato Emily Xiao Devika Manoj Connecting DCX, COMT and FMR1 in social behavior and cognitive impairment Behavioral and Brain Functions Intellectual disability Social behavior Neurogenesis Hippocampus Wnt signaling COMT |
| title | Connecting DCX, COMT and FMR1 in social behavior and cognitive impairment |
| title_full | Connecting DCX, COMT and FMR1 in social behavior and cognitive impairment |
| title_fullStr | Connecting DCX, COMT and FMR1 in social behavior and cognitive impairment |
| title_full_unstemmed | Connecting DCX, COMT and FMR1 in social behavior and cognitive impairment |
| title_short | Connecting DCX, COMT and FMR1 in social behavior and cognitive impairment |
| title_sort | connecting dcx comt and fmr1 in social behavior and cognitive impairment |
| topic | Intellectual disability Social behavior Neurogenesis Hippocampus Wnt signaling COMT |
| url | https://doi.org/10.1186/s12993-022-00191-7 |
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