Compromised T Cell Immunity Links Increased Cutaneous Papillomavirus Activity to Squamous Cell Carcinoma Risk
Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer, with increased incidence in immunosuppressed patients. β-Human papillomavirus has been proposed as a contributor to cSCC risk partly on the basis of increased β-human papillomavirus viral load and seropositivity observed amon...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | JID Innovations |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667026722000716 |
| _version_ | 1827976738632630272 |
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| author | Luke H. Johnson Heehwa G. Son Dat Thinh Ha John D. Strickley Joongho Joh Shadmehr Demehri |
| author_facet | Luke H. Johnson Heehwa G. Son Dat Thinh Ha John D. Strickley Joongho Joh Shadmehr Demehri |
| author_sort | Luke H. Johnson |
| collection | DOAJ |
| description | Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer, with increased incidence in immunosuppressed patients. β-Human papillomavirus has been proposed as a contributor to cSCC risk partly on the basis of increased β-human papillomavirus viral load and seropositivity observed among patients with cSCC. Experimental data in mice colonized with mouse papillomavirus type 1 suggest that T cell immunity against β-human papillomavirus suppresses skin cancer in immunocompetent hosts, and the loss of this immunity leads to the increased risk of cSCC. In this study, we show that CD8+ T cell depletion in mouse papillomavirus type 1‒colonized mice that underwent skin carcinogenesis protocol led to increased viral load in the skin and seropositivity for anti‒mouse papillomavirus type 1 antibodies. These findings provide evidence that compromised T cell immunity can be the link that connects increased β-human papillomavirus detection to cSCC risk. |
| first_indexed | 2024-04-09T20:40:19Z |
| format | Article |
| id | doaj.art-9990bd65a89343b0a082d1b0498ad838 |
| institution | Directory Open Access Journal |
| issn | 2667-0267 |
| language | English |
| last_indexed | 2024-04-09T20:40:19Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JID Innovations |
| spelling | doaj.art-9990bd65a89343b0a082d1b0498ad8382023-03-30T04:27:19ZengElsevierJID Innovations2667-02672023-03-0132100163Compromised T Cell Immunity Links Increased Cutaneous Papillomavirus Activity to Squamous Cell Carcinoma RiskLuke H. Johnson0Heehwa G. Son1Dat Thinh Ha2John D. Strickley3Joongho Joh4Shadmehr Demehri5University of Louisville School of Medicine, Louisville, Kentucky, USA; Center for Cancer Immunology, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USACenter for Cancer Immunology, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USACenter for Cancer Immunology, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USAUniversity of Louisville School of Medicine, Louisville, Kentucky, USA; Center for Cancer Immunology, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USADepartment of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USACenter for Cancer Immunology, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Correspondence: Shadmehr Demehri, Department of Dermatology and Cancer Center, Massachusetts General Hospital, 149 13th Street, 3rd Floor, Boston, Massachusetts 02114-2621, USA.Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer, with increased incidence in immunosuppressed patients. β-Human papillomavirus has been proposed as a contributor to cSCC risk partly on the basis of increased β-human papillomavirus viral load and seropositivity observed among patients with cSCC. Experimental data in mice colonized with mouse papillomavirus type 1 suggest that T cell immunity against β-human papillomavirus suppresses skin cancer in immunocompetent hosts, and the loss of this immunity leads to the increased risk of cSCC. In this study, we show that CD8+ T cell depletion in mouse papillomavirus type 1‒colonized mice that underwent skin carcinogenesis protocol led to increased viral load in the skin and seropositivity for anti‒mouse papillomavirus type 1 antibodies. These findings provide evidence that compromised T cell immunity can be the link that connects increased β-human papillomavirus detection to cSCC risk.http://www.sciencedirect.com/science/article/pii/S2667026722000716 |
| spellingShingle | Luke H. Johnson Heehwa G. Son Dat Thinh Ha John D. Strickley Joongho Joh Shadmehr Demehri Compromised T Cell Immunity Links Increased Cutaneous Papillomavirus Activity to Squamous Cell Carcinoma Risk JID Innovations |
| title | Compromised T Cell Immunity Links Increased Cutaneous Papillomavirus Activity to Squamous Cell Carcinoma Risk |
| title_full | Compromised T Cell Immunity Links Increased Cutaneous Papillomavirus Activity to Squamous Cell Carcinoma Risk |
| title_fullStr | Compromised T Cell Immunity Links Increased Cutaneous Papillomavirus Activity to Squamous Cell Carcinoma Risk |
| title_full_unstemmed | Compromised T Cell Immunity Links Increased Cutaneous Papillomavirus Activity to Squamous Cell Carcinoma Risk |
| title_short | Compromised T Cell Immunity Links Increased Cutaneous Papillomavirus Activity to Squamous Cell Carcinoma Risk |
| title_sort | compromised t cell immunity links increased cutaneous papillomavirus activity to squamous cell carcinoma risk |
| url | http://www.sciencedirect.com/science/article/pii/S2667026722000716 |
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