Glutathione deficit during development induces anomalies in the rat anterior cingulate GABAergic neurons: Relevance to schizophrenia

Glutathione deficit during development induces anomalies in the rat anterior cingulate GABAergic neurons: Relevance to schizophrenia

A series of studies in schizophrenic patients report a decrease of glutathione (GSH) in prefrontal cortex (PFC) and cerebrospinal fluid, a decrease in mRNA levels for two GSH synthesizing enzymes and a deficit in parvalbumin (PV) expression in a subclass of GABA neurons in PFC. GSH is an important r...

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Bibliographic Details
Main Authors: Jan-Harry Cabungcal, Dominique Nicolas, Rudolf Kraftsik, Michel Cuénod, Kim Q. Do, Jean-Pierre Hornung
Format: Article
Language:English
Published: Elsevier 2006-06-01
Series:Neurobiology of Disease
Subjects:
Animal model
Anterior cingulate cortex
γ-amino butyric acid
Glutathione
GBR 12909
Inhibitory interneurons
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106000052

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