| Summary: | Majdi Al Qawasmeh, Belal Aldabbour, Kefah Alhayek, Khalid El-Salem Department of Neurology, King Abdullah University Hospital (KAUH), Jordan University of Science and Technology (JUST), Irbid, JordanCorrespondence: Majdi Al QawasmehNeurology Department of KAUH, King Abdullah University Hospital, P.O. Box 630001, Irbid 22110, JordanTel +962 797477731Email m0alqawasmeh@just.edu.joAbstract: Encephalocraniocutaneous lipomatosis “ECCL” is a rare, sporadic neurocutaneous disorder that results from a lethal autosomal mutation surviving by somatic mosaicism. It is characterized by unilateral involvement of skin, eyes and central nervous system in addition to a propensity for mesenchymal tumors. A 30-year-old male with previously controlled epilepsy presented with recurrent seizures. Brain imaging revealed a left parietal parasagittal enhancing tumor, in addition to left sided gyriform calcifications, and bilateral cerebral atrophy and ventricular dilatation more prominent on the left side. He also presented multiple left sided sebaceous nevi and abundant subcutaneous lipomas in addition to left mandibular condylar cysts. The brain tumor was excised, and cytopathology revealed a WHO grade I fibrous meningioma. After a thorough evaluation and exclusion of alternative diagnoses, the patient was diagnosed with definite encephalocraniocutaneous lipomatosis as per Moog’s criteria. Several cases of ECCL recently presented with different intracranial neoplasms. Here we report the first case of ECCL in association with meningioma.Keywords: neurocutaneous syndromes, neurocutaneous disorders, encephalocraniocutaneous lipomatosis, Haberland syndrome
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