Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis
Severe acne is a chronic inflammatory skin condition that is affected by both genetic and environmental factors. DNA methylation is associated with a variety of inflammatory skin diseases, but its role in severe acne is unclear. In this study, we conducted a two-stage epigenome correlation study usi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
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| Series: | Epigenetics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15592294.2023.2199373 |
| _version_ | 1797678831598829568 |
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| author | Huai Wang Tianyuan Dang Jiaqi Feng Wenjuan Wu Li He Jiankang Yang |
| author_facet | Huai Wang Tianyuan Dang Jiaqi Feng Wenjuan Wu Li He Jiankang Yang |
| author_sort | Huai Wang |
| collection | DOAJ |
| description | Severe acne is a chronic inflammatory skin condition that is affected by both genetic and environmental factors. DNA methylation is associated with a variety of inflammatory skin diseases, but its role in severe acne is unclear. In this study, we conducted a two-stage epigenome correlation study using 88 blood samples to identify disease-related differential methylation sites. We found close associations between the DNA methylation at 23 differentially methylated sites (DMSs) and severe acne, including PDGFD, ARHGEF10, etc. Further analysis revealed that differentially methylated genes (PARP8 and MAPKAPK2) were also expressed differently between severe acne and health control groups. These findings lead us to speculation that epigenetic mechanisms may play an important role in the pathogenesis of severe acne. |
| first_indexed | 2024-03-11T23:05:42Z |
| format | Article |
| id | doaj.art-99960c60da9648b4997dfb13697e4b64 |
| institution | Directory Open Access Journal |
| issn | 1559-2294 1559-2308 |
| language | English |
| last_indexed | 2024-03-11T23:05:42Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj.art-99960c60da9648b4997dfb13697e4b642023-09-21T13:23:13ZengTaylor & Francis GroupEpigenetics1559-22941559-23082023-12-0118110.1080/15592294.2023.21993732199373Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysisHuai Wang0Tianyuan Dang1Jiaqi Feng2Wenjuan Wu3Li He4Jiankang Yang5Dali UniversityFirst Affiliated Hospital of Kunming Medical UniversityFirst Affiliated Hospital of Kunming Medical UniversityFirst Affiliated Hospital of Kunming Medical UniversityFirst Affiliated Hospital of Kunming Medical UniversityDali UniversitySevere acne is a chronic inflammatory skin condition that is affected by both genetic and environmental factors. DNA methylation is associated with a variety of inflammatory skin diseases, but its role in severe acne is unclear. In this study, we conducted a two-stage epigenome correlation study using 88 blood samples to identify disease-related differential methylation sites. We found close associations between the DNA methylation at 23 differentially methylated sites (DMSs) and severe acne, including PDGFD, ARHGEF10, etc. Further analysis revealed that differentially methylated genes (PARP8 and MAPKAPK2) were also expressed differently between severe acne and health control groups. These findings lead us to speculation that epigenetic mechanisms may play an important role in the pathogenesis of severe acne.http://dx.doi.org/10.1080/15592294.2023.2199373dna methylationepigeneticsexpressionacne |
| spellingShingle | Huai Wang Tianyuan Dang Jiaqi Feng Wenjuan Wu Li He Jiankang Yang Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis Epigenetics dna methylation epigenetics expression acne |
| title | Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis |
| title_full | Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis |
| title_fullStr | Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis |
| title_full_unstemmed | Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis |
| title_short | Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis |
| title_sort | identification of differentially methylated genes for severe acne by genome wide dna methylation and gene expression analysis |
| topic | dna methylation epigenetics expression acne |
| url | http://dx.doi.org/10.1080/15592294.2023.2199373 |
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