Splenectomy in the management of primary immune‐mediated hemolytic anemia and primary immune‐mediated thrombocytopenia in dogs
Abstract Background Current reports about the use of splenectomy for the management of immune‐mediated hemolytic anemia (IMHA) or immune‐mediated thrombocytopenia (ITP) or both in dogs are limited. Objectives To retrospectively describe the use of splenectomy as part of the management for IMHA, ITP,...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-07-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.16469 |
| _version_ | 1818512128780271616 |
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| author | Jason P. Bestwick Barbara J. Skelly James W. Swann Barbara Glanemann Nick Bexfield Zeta Gkoka David J. Walker Paolo Silvestrini Sophie Adamantos Mayank Seth James Warland |
| author_facet | Jason P. Bestwick Barbara J. Skelly James W. Swann Barbara Glanemann Nick Bexfield Zeta Gkoka David J. Walker Paolo Silvestrini Sophie Adamantos Mayank Seth James Warland |
| author_sort | Jason P. Bestwick |
| collection | DOAJ |
| description | Abstract Background Current reports about the use of splenectomy for the management of immune‐mediated hemolytic anemia (IMHA) or immune‐mediated thrombocytopenia (ITP) or both in dogs are limited. Objectives To retrospectively describe the use of splenectomy as part of the management for IMHA, ITP, and concurrent IMHA and severe thrombocytopenia (CIST) in dogs. It was hypothesized that splenectomy would be beneficial in allowing for reduction of dose of immunosuppressive drugs or discontinuation in 1 or more of these groups. Animals Seventeen client‐owned dogs (7 with IMHA, 7 with ITP, and 3 with CIST) were identified across 7 UK‐based referral hospitals from a study period of 2005 to 2016. Methods Data were collected retrospectively via questionnaires and included information about diagnosis, management and treatment response before and after splenectomy. Based on clinical outcome, treatment with splenectomy as part of the management protocol was classified as either successful or unsuccessful. Results Six of 7 dogs with ITP were managed successfully with splenectomy as part of their management protocol (3 complete and 3 partial responses), although 1 subsequently developed suspected IMHA. Of the 7 dogs with IMHA, splenectomy was part of a successful management protocol in 4 dogs (2 complete and 2 partial responses). In the CIST group, 1 case (1/3) responded completely to management with splenectomy as part of the management protocol. Conclusions and Clinical Importance Splenectomy was considered successful and well tolerated in most cases of isolated ITP. Whether there is a benefit of splenectomy in cases of IMHA and CIST could not be determined in the current study. |
| first_indexed | 2024-12-10T23:42:40Z |
| format | Article |
| id | doaj.art-999755ca02e04c4bbdbcc3bdff03fae4 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-12-10T23:42:40Z |
| publishDate | 2022-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-999755ca02e04c4bbdbcc3bdff03fae42022-12-22T01:29:00ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762022-07-013641267128010.1111/jvim.16469Splenectomy in the management of primary immune‐mediated hemolytic anemia and primary immune‐mediated thrombocytopenia in dogsJason P. Bestwick0Barbara J. Skelly1James W. Swann2Barbara Glanemann3Nick Bexfield4Zeta Gkoka5David J. Walker6Paolo Silvestrini7Sophie Adamantos8Mayank Seth9James Warland10Animal Health Trust Newmarket Suffolk United KingdomQueen's Veterinary School Hospital University of Cambridge Cambridge United KingdomDepartment of Clinical Science and Services The Royal Veterinary College, University of London Hertfordshire United KingdomDepartment of Clinical Science and Services The Royal Veterinary College, University of London Hertfordshire United KingdomQueen's Veterinary School Hospital University of Cambridge Cambridge United KingdomAnderson Moores Veterinary Specialists Winchester United KingdomAnderson Moores Veterinary Specialists Winchester United KingdomSmall Animal Teaching Hospital Institute of Veterinary Science, University of Liverpool Neston United KingdomLangford Vets/University of Bristol Bristol North Somerset United KingdomAnimal Health Trust Newmarket Suffolk United KingdomAnimal Health Trust Newmarket Suffolk United KingdomAbstract Background Current reports about the use of splenectomy for the management of immune‐mediated hemolytic anemia (IMHA) or immune‐mediated thrombocytopenia (ITP) or both in dogs are limited. Objectives To retrospectively describe the use of splenectomy as part of the management for IMHA, ITP, and concurrent IMHA and severe thrombocytopenia (CIST) in dogs. It was hypothesized that splenectomy would be beneficial in allowing for reduction of dose of immunosuppressive drugs or discontinuation in 1 or more of these groups. Animals Seventeen client‐owned dogs (7 with IMHA, 7 with ITP, and 3 with CIST) were identified across 7 UK‐based referral hospitals from a study period of 2005 to 2016. Methods Data were collected retrospectively via questionnaires and included information about diagnosis, management and treatment response before and after splenectomy. Based on clinical outcome, treatment with splenectomy as part of the management protocol was classified as either successful or unsuccessful. Results Six of 7 dogs with ITP were managed successfully with splenectomy as part of their management protocol (3 complete and 3 partial responses), although 1 subsequently developed suspected IMHA. Of the 7 dogs with IMHA, splenectomy was part of a successful management protocol in 4 dogs (2 complete and 2 partial responses). In the CIST group, 1 case (1/3) responded completely to management with splenectomy as part of the management protocol. Conclusions and Clinical Importance Splenectomy was considered successful and well tolerated in most cases of isolated ITP. Whether there is a benefit of splenectomy in cases of IMHA and CIST could not be determined in the current study.https://doi.org/10.1111/jvim.16469AIHAautoimmuneIMHAITPspleen |
| spellingShingle | Jason P. Bestwick Barbara J. Skelly James W. Swann Barbara Glanemann Nick Bexfield Zeta Gkoka David J. Walker Paolo Silvestrini Sophie Adamantos Mayank Seth James Warland Splenectomy in the management of primary immune‐mediated hemolytic anemia and primary immune‐mediated thrombocytopenia in dogs Journal of Veterinary Internal Medicine AIHA autoimmune IMHA ITP spleen |
| title | Splenectomy in the management of primary immune‐mediated hemolytic anemia and primary immune‐mediated thrombocytopenia in dogs |
| title_full | Splenectomy in the management of primary immune‐mediated hemolytic anemia and primary immune‐mediated thrombocytopenia in dogs |
| title_fullStr | Splenectomy in the management of primary immune‐mediated hemolytic anemia and primary immune‐mediated thrombocytopenia in dogs |
| title_full_unstemmed | Splenectomy in the management of primary immune‐mediated hemolytic anemia and primary immune‐mediated thrombocytopenia in dogs |
| title_short | Splenectomy in the management of primary immune‐mediated hemolytic anemia and primary immune‐mediated thrombocytopenia in dogs |
| title_sort | splenectomy in the management of primary immune mediated hemolytic anemia and primary immune mediated thrombocytopenia in dogs |
| topic | AIHA autoimmune IMHA ITP spleen |
| url | https://doi.org/10.1111/jvim.16469 |
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