Brain Perivascular Macrophages Do Not Mediate Interleukin-1-Induced Sickness Behavior in Rats

Brain Perivascular Macrophages Do Not Mediate Interleukin-1-Induced Sickness Behavior in Rats

Sickness behavior, characterized by on overall reduction in behavioral activity, is commonly observed after bacterial infection. Sickness behavior can also be induced by the peripheral administration of Gram-negative bacterial lipopolysaccharide (LPS) or interleukin-1beta (IL-1β), a pro-inflammatory...

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Bibliographic Details
Main Authors: Léa Chaskiel, Robert Dantzer, Jan Pieter Konsman
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pharmaceuticals
Subjects:
brain perivascular macrophages
food intake
interleukin-1
locomotor activity
social interaction
Online Access:https://www.mdpi.com/1424-8247/14/10/1030

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