Clinical Significance of Low-Flow Time in Patients Undergoing Extracorporeal Cardiopulmonary Resuscitation: Results from the RESCUE Registry
Limited data are available on the association between low-flow time and survival in patients with in-hospital cardiac arrest (IHCA) who undergo extracorporeal cardiopulmonary resuscitation (ECPR). We evaluated data from 183 IHCA patients who underwent ECPR as a rescue procedure. Patients were divide...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/11/3588 |
| _version_ | 1797548626066538496 |
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| author | Ik Hyun Park Jeong Hoon Yang Woo Jin Jang Woo Jung Chun Ju Hyeon Oh Yong Hwan Park Cheol Woong Yu Hyun-Joong Kim Bum Sung Kim Jin-Ok Jeong Hyun Jong Lee Hyeon-Cheol Gwon |
| author_facet | Ik Hyun Park Jeong Hoon Yang Woo Jin Jang Woo Jung Chun Ju Hyeon Oh Yong Hwan Park Cheol Woong Yu Hyun-Joong Kim Bum Sung Kim Jin-Ok Jeong Hyun Jong Lee Hyeon-Cheol Gwon |
| author_sort | Ik Hyun Park |
| collection | DOAJ |
| description | Limited data are available on the association between low-flow time and survival in patients with in-hospital cardiac arrest (IHCA) who undergo extracorporeal cardiopulmonary resuscitation (ECPR). We evaluated data from 183 IHCA patients who underwent ECPR as a rescue procedure. Patients were divided into two groups: patients undergoing extracorporeal membrane oxygenation as an adjunct to standard cardiopulmonary resuscitation for less than 38 min (<i>n</i> = 110) or for longer than 38 min (<i>n</i> = 73). The ECPR ≤ 38 min group had a significantly greater incidence of survival to discharge compared to the ECPR > 38 min group (40.0% versus 24.7%, <i>p</i> = 0.032). The incidence of good neurologic outcomes at discharge tended to be greater in the ECPR ≤ 38 min group than in the ECPR > 38 min group (35.5% versus 24.7%, <i>p</i> = 0.102). The incidences of limb ischemia (<i>p</i> = 0.354) and stroke (<i>p</i> = 0.805) were similar between the two groups, but major bleeding occurred less frequently in the ECPR ≤ 38 min group compared to the ECPR > 38 min group (<i>p</i> = 0.002). Low-flow time ≤ 38 min may reduce the risk of mortality and fatal neurologic damage and could be a measure of optimal management in patients with IHCA. |
| first_indexed | 2024-03-10T15:02:18Z |
| format | Article |
| id | doaj.art-9998baf45eee4cb7bb54ad00a308830e |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T15:02:18Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-9998baf45eee4cb7bb54ad00a308830e2023-11-20T20:05:59ZengMDPI AGJournal of Clinical Medicine2077-03832020-11-01911358810.3390/jcm9113588Clinical Significance of Low-Flow Time in Patients Undergoing Extracorporeal Cardiopulmonary Resuscitation: Results from the RESCUE RegistryIk Hyun Park0Jeong Hoon Yang1Woo Jin Jang2Woo Jung Chun3Ju Hyeon Oh4Yong Hwan Park5Cheol Woong Yu6Hyun-Joong Kim7Bum Sung Kim8Jin-Ok Jeong9Hyun Jong Lee10Hyeon-Cheol Gwon11Division of Cardiology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon 51353, KoreaDivision of Cardiology, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaDivision of Cardiology, Department of Internal Medicine, Seoul Hospital, Ewha Womans University College of Medicine, Seoul 07804, KoreaDivision of Cardiology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon 51353, KoreaDivision of Cardiology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon 51353, KoreaDivision of Cardiology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon 51353, KoreaDivision of Cardiology, Department of Internal Medicine, Korea University Anam Hospital, Seoul 02841, KoreaDivision of Cardiology, Department of Medicine, Konkuk University Medical Center, Seoul 05030, KoreaDivision of Cardiology, Department of Medicine, Konkuk University Medical Center, Seoul 05030, KoreaDivision of Cardiology, Department of Internal Medicine, Chungnam National University Hospital, Daejeon 35015, KoreaDivision of Cardiology, Department of Medicine, Sejong General Hospital, Bucheon 14754, KoreaDivision of Cardiology, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaLimited data are available on the association between low-flow time and survival in patients with in-hospital cardiac arrest (IHCA) who undergo extracorporeal cardiopulmonary resuscitation (ECPR). We evaluated data from 183 IHCA patients who underwent ECPR as a rescue procedure. Patients were divided into two groups: patients undergoing extracorporeal membrane oxygenation as an adjunct to standard cardiopulmonary resuscitation for less than 38 min (<i>n</i> = 110) or for longer than 38 min (<i>n</i> = 73). The ECPR ≤ 38 min group had a significantly greater incidence of survival to discharge compared to the ECPR > 38 min group (40.0% versus 24.7%, <i>p</i> = 0.032). The incidence of good neurologic outcomes at discharge tended to be greater in the ECPR ≤ 38 min group than in the ECPR > 38 min group (35.5% versus 24.7%, <i>p</i> = 0.102). The incidences of limb ischemia (<i>p</i> = 0.354) and stroke (<i>p</i> = 0.805) were similar between the two groups, but major bleeding occurred less frequently in the ECPR ≤ 38 min group compared to the ECPR > 38 min group (<i>p</i> = 0.002). Low-flow time ≤ 38 min may reduce the risk of mortality and fatal neurologic damage and could be a measure of optimal management in patients with IHCA.https://www.mdpi.com/2077-0383/9/11/3588extracorporeal cardiopulmonary resuscitationin-hospital cardiac arrestlow-flow timevasoactive inotropic score |
| spellingShingle | Ik Hyun Park Jeong Hoon Yang Woo Jin Jang Woo Jung Chun Ju Hyeon Oh Yong Hwan Park Cheol Woong Yu Hyun-Joong Kim Bum Sung Kim Jin-Ok Jeong Hyun Jong Lee Hyeon-Cheol Gwon Clinical Significance of Low-Flow Time in Patients Undergoing Extracorporeal Cardiopulmonary Resuscitation: Results from the RESCUE Registry Journal of Clinical Medicine extracorporeal cardiopulmonary resuscitation in-hospital cardiac arrest low-flow time vasoactive inotropic score |
| title | Clinical Significance of Low-Flow Time in Patients Undergoing Extracorporeal Cardiopulmonary Resuscitation: Results from the RESCUE Registry |
| title_full | Clinical Significance of Low-Flow Time in Patients Undergoing Extracorporeal Cardiopulmonary Resuscitation: Results from the RESCUE Registry |
| title_fullStr | Clinical Significance of Low-Flow Time in Patients Undergoing Extracorporeal Cardiopulmonary Resuscitation: Results from the RESCUE Registry |
| title_full_unstemmed | Clinical Significance of Low-Flow Time in Patients Undergoing Extracorporeal Cardiopulmonary Resuscitation: Results from the RESCUE Registry |
| title_short | Clinical Significance of Low-Flow Time in Patients Undergoing Extracorporeal Cardiopulmonary Resuscitation: Results from the RESCUE Registry |
| title_sort | clinical significance of low flow time in patients undergoing extracorporeal cardiopulmonary resuscitation results from the rescue registry |
| topic | extracorporeal cardiopulmonary resuscitation in-hospital cardiac arrest low-flow time vasoactive inotropic score |
| url | https://www.mdpi.com/2077-0383/9/11/3588 |
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