K<sub>V</sub>11.1, Na<sub>V</sub>1.5, and Ca<sub>V</sub>1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity
Safety assessment of pharmaceuticals is a rapidly developing area of pharmacy and medicine. The new advanced guidelines for testing the toxicity of compounds require specialized tools that provide information on the tested drug in a quick and reliable way. Ion channels represent the third-largest ta...
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| Format: | Article |
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MDPI AG
2020-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/21/8099 |
| _version_ | 1797549329230069760 |
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| author | Magdalena Kowalska Jacek Nowaczyk Alicja Nowaczyk |
| author_facet | Magdalena Kowalska Jacek Nowaczyk Alicja Nowaczyk |
| author_sort | Magdalena Kowalska |
| collection | DOAJ |
| description | Safety assessment of pharmaceuticals is a rapidly developing area of pharmacy and medicine. The new advanced guidelines for testing the toxicity of compounds require specialized tools that provide information on the tested drug in a quick and reliable way. Ion channels represent the third-largest target. As mentioned in the literature, ion channels are an indispensable part of the heart’s work. In this paper the most important information concerning the guidelines for cardiotoxicity testing and the way the tests are conducted has been collected. Attention has been focused on the role of selected ion channels in this process. |
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| format | Article |
| id | doaj.art-99997b8a2a1a47dd8338d660b2b3cb29 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:13:08Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-99997b8a2a1a47dd8338d660b2b3cb292023-11-20T19:08:58ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-10-012121809910.3390/ijms21218099K<sub>V</sub>11.1, Na<sub>V</sub>1.5, and Ca<sub>V</sub>1.2 Transporter Proteins as Antitarget for Drug CardiotoxicityMagdalena Kowalska0Jacek Nowaczyk1Alicja Nowaczyk2Department of Organic Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 85-094 Bydgoszcz, PolandFaculty of Chemistry, Nicolaus Copernicus University, 87-100 Toruń, PolandDepartment of Organic Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 85-094 Bydgoszcz, PolandSafety assessment of pharmaceuticals is a rapidly developing area of pharmacy and medicine. The new advanced guidelines for testing the toxicity of compounds require specialized tools that provide information on the tested drug in a quick and reliable way. Ion channels represent the third-largest target. As mentioned in the literature, ion channels are an indispensable part of the heart’s work. In this paper the most important information concerning the guidelines for cardiotoxicity testing and the way the tests are conducted has been collected. Attention has been focused on the role of selected ion channels in this process.https://www.mdpi.com/1422-0067/21/21/8099antitargetdrug cardiotoxicityion transporter proteins |
| spellingShingle | Magdalena Kowalska Jacek Nowaczyk Alicja Nowaczyk K<sub>V</sub>11.1, Na<sub>V</sub>1.5, and Ca<sub>V</sub>1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity International Journal of Molecular Sciences antitarget drug cardiotoxicity ion transporter proteins |
| title | K<sub>V</sub>11.1, Na<sub>V</sub>1.5, and Ca<sub>V</sub>1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity |
| title_full | K<sub>V</sub>11.1, Na<sub>V</sub>1.5, and Ca<sub>V</sub>1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity |
| title_fullStr | K<sub>V</sub>11.1, Na<sub>V</sub>1.5, and Ca<sub>V</sub>1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity |
| title_full_unstemmed | K<sub>V</sub>11.1, Na<sub>V</sub>1.5, and Ca<sub>V</sub>1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity |
| title_short | K<sub>V</sub>11.1, Na<sub>V</sub>1.5, and Ca<sub>V</sub>1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity |
| title_sort | k sub v sub 11 1 na sub v sub 1 5 and ca sub v sub 1 2 transporter proteins as antitarget for drug cardiotoxicity |
| topic | antitarget drug cardiotoxicity ion transporter proteins |
| url | https://www.mdpi.com/1422-0067/21/21/8099 |
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