A Concise Synthesis of Sacidumlignan B
A short synthesis of racemic Sacidumlignan B was achieved for the first time. The key steps included a formal reductive coupling between the diaryl ketone and the crotyl bromide, and the subsequent Friedel–Crafts cyclization, which led to an efficient construction of dihydronaphthalene skeleton in t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/18/5775 |
| _version_ | 1797484395987206144 |
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| author | Zhiyuan Zhuang Zhenbiao Luo Sichen Yao Yawen Wang Yu Peng |
| author_facet | Zhiyuan Zhuang Zhenbiao Luo Sichen Yao Yawen Wang Yu Peng |
| author_sort | Zhiyuan Zhuang |
| collection | DOAJ |
| description | A short synthesis of racemic Sacidumlignan B was achieved for the first time. The key steps included a formal reductive coupling between the diaryl ketone and the crotyl bromide, and the subsequent Friedel–Crafts cyclization, which led to an efficient construction of dihydronaphthalene skeleton in this 2,7′-cyclolignan natural product. |
| first_indexed | 2024-03-09T23:03:09Z |
| format | Article |
| id | doaj.art-99999368ec51481f8c001b53316c42f8 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T23:03:09Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-99999368ec51481f8c001b53316c42f82023-11-23T17:58:40ZengMDPI AGMolecules1420-30492022-09-012718577510.3390/molecules27185775A Concise Synthesis of Sacidumlignan BZhiyuan Zhuang0Zhenbiao Luo1Sichen Yao2Yawen Wang3Yu Peng4State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, ChinaState Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, ChinaSichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, ChinaSichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, ChinaSichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, ChinaA short synthesis of racemic Sacidumlignan B was achieved for the first time. The key steps included a formal reductive coupling between the diaryl ketone and the crotyl bromide, and the subsequent Friedel–Crafts cyclization, which led to an efficient construction of dihydronaphthalene skeleton in this 2,7′-cyclolignan natural product.https://www.mdpi.com/1420-3049/27/18/5775cyclolignantotal synthesiscyclizationsynthetic efficiencyBarbier reaction |
| spellingShingle | Zhiyuan Zhuang Zhenbiao Luo Sichen Yao Yawen Wang Yu Peng A Concise Synthesis of Sacidumlignan B Molecules cyclolignan total synthesis cyclization synthetic efficiency Barbier reaction |
| title | A Concise Synthesis of Sacidumlignan B |
| title_full | A Concise Synthesis of Sacidumlignan B |
| title_fullStr | A Concise Synthesis of Sacidumlignan B |
| title_full_unstemmed | A Concise Synthesis of Sacidumlignan B |
| title_short | A Concise Synthesis of Sacidumlignan B |
| title_sort | concise synthesis of sacidumlignan b |
| topic | cyclolignan total synthesis cyclization synthetic efficiency Barbier reaction |
| url | https://www.mdpi.com/1420-3049/27/18/5775 |
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