Mapping the motor cortex with BOLD functional magnetic resonance imaging
Introduction – Functional magnetic resonance imaging (fMRI) is currently an essential tool for the study of human brain function, both in healthy volunteers and in patients suffering from multiple types of pathology. fMRI is a complex technique which needs to be applied in a careful and rigorous man...
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| Format: | Article |
| Language: | English |
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Escola Superior de Tecnologia da Saúde de Lisboa
2015-12-01
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| Series: | Saúde & Tecnologia |
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| Online Access: | https://web.estesl.ipl.pt/ojs/index.php/ST/article/view/1034 |
| _version_ | 1827280442496122880 |
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| author | Patrícia R. Nunes Sandra R. Tecelão Rita G. Nunes |
| author_facet | Patrícia R. Nunes Sandra R. Tecelão Rita G. Nunes |
| author_sort | Patrícia R. Nunes |
| collection | DOAJ |
| description | Introduction – Functional magnetic resonance imaging (fMRI) is currently an essential tool for the study of human brain function, both in healthy volunteers and in patients suffering from multiple types of pathology. fMRI is a complex technique which needs to be applied in a careful and rigorous manner, requiring an understanding of its biophysical mechanisms so that reliable results with clinical acceptance can be obtained. The BOLD effect (Blood Oxygenation Level Dependent) is based on the magnetic properties of haemoglobin and it is the most used approach for measuring brain activity using MRI. Goals – To optimise a BOLD fMRI protocol on healthy volunteers for mapping the motor cortex, so that it can be applied to patients in the clinic. Methods – 34 healthy volunteers were divided into 2 study groups: BOLD 1 and BOLD 2. To optimise the acquisition, different paradigms were tested on sub-group BOLD 1. The influence of the echo time (TE) was studied on sub-group BOLD 2.The volume and activation level of the activated regions were compared under the different sets of conditions. Results/Discussion – It was possible to identify the motor cortex on all studied individuals. No significant statistical differences were detected when comparing the results obtained with the different acquisition parameters. Conclusion – The protocolwas optimised taking into account the level of comfort reported by the volunteers. Given that the goal is to use this protocol to study patients, comfort is a particularly important factor. |
| first_indexed | 2024-04-24T08:41:18Z |
| format | Article |
| id | doaj.art-999a21b7db7e4bba86ccf3679bcffd5f |
| institution | Directory Open Access Journal |
| issn | 1646-9704 |
| language | English |
| last_indexed | 2024-04-24T08:41:18Z |
| publishDate | 2015-12-01 |
| publisher | Escola Superior de Tecnologia da Saúde de Lisboa |
| record_format | Article |
| series | Saúde & Tecnologia |
| spelling | doaj.art-999a21b7db7e4bba86ccf3679bcffd5f2024-04-16T15:50:42ZengEscola Superior de Tecnologia da Saúde de LisboaSaúde & Tecnologia1646-97042015-12-0100e11e1110.25758/s&t.v0i0.10341044Mapping the motor cortex with BOLD functional magnetic resonance imagingPatrícia R. Nunes0Sandra R. Tecelão1Rita G. Nunes2Mestrado em Radiações Aplicadas às Tecnologias da Saúde – Área de especialização: Ressonância Magnética, Escola Superior de Tecnologia da Saúde de Lisboa, Instituto Politécnico de Lisboa; Serviço de Imagiologia, Quadrantes – Clínica Médica e de DiagnósticoDepartamento das Ciências da Saúde, Universidade AtlânticaInstituto de Biofísica e Engenharia Biomédica, Faculdade de Ciências, Universidade de LisboaIntroduction – Functional magnetic resonance imaging (fMRI) is currently an essential tool for the study of human brain function, both in healthy volunteers and in patients suffering from multiple types of pathology. fMRI is a complex technique which needs to be applied in a careful and rigorous manner, requiring an understanding of its biophysical mechanisms so that reliable results with clinical acceptance can be obtained. The BOLD effect (Blood Oxygenation Level Dependent) is based on the magnetic properties of haemoglobin and it is the most used approach for measuring brain activity using MRI. Goals – To optimise a BOLD fMRI protocol on healthy volunteers for mapping the motor cortex, so that it can be applied to patients in the clinic. Methods – 34 healthy volunteers were divided into 2 study groups: BOLD 1 and BOLD 2. To optimise the acquisition, different paradigms were tested on sub-group BOLD 1. The influence of the echo time (TE) was studied on sub-group BOLD 2.The volume and activation level of the activated regions were compared under the different sets of conditions. Results/Discussion – It was possible to identify the motor cortex on all studied individuals. No significant statistical differences were detected when comparing the results obtained with the different acquisition parameters. Conclusion – The protocolwas optimised taking into account the level of comfort reported by the volunteers. Given that the goal is to use this protocol to study patients, comfort is a particularly important factor.https://web.estesl.ipl.pt/ojs/index.php/ST/article/view/1034BOLD, córtex motor, paradigma, ressonância magnética funcional (RMf), TE (tempo de eco). |
| spellingShingle | Patrícia R. Nunes Sandra R. Tecelão Rita G. Nunes Mapping the motor cortex with BOLD functional magnetic resonance imaging Saúde & Tecnologia BOLD, córtex motor, paradigma, ressonância magnética funcional (RMf), TE (tempo de eco). |
| title | Mapping the motor cortex with BOLD functional magnetic resonance imaging |
| title_full | Mapping the motor cortex with BOLD functional magnetic resonance imaging |
| title_fullStr | Mapping the motor cortex with BOLD functional magnetic resonance imaging |
| title_full_unstemmed | Mapping the motor cortex with BOLD functional magnetic resonance imaging |
| title_short | Mapping the motor cortex with BOLD functional magnetic resonance imaging |
| title_sort | mapping the motor cortex with bold functional magnetic resonance imaging |
| topic | BOLD, córtex motor, paradigma, ressonância magnética funcional (RMf), TE (tempo de eco). |
| url | https://web.estesl.ipl.pt/ojs/index.php/ST/article/view/1034 |
| work_keys_str_mv | AT patriciarnunes mappingthemotorcortexwithboldfunctionalmagneticresonanceimaging AT sandrartecelao mappingthemotorcortexwithboldfunctionalmagneticresonanceimaging AT ritagnunes mappingthemotorcortexwithboldfunctionalmagneticresonanceimaging |