Epidemiology and Clinical Characteristics of Human Coronaviruses-Associated Infections in Children: A Multi-Center Study
BackgroundHuman coronaviruses (HCoVs) are associated with upper respiratory tract infections. Although studies have analyzed the clinical and epidemiological characteristics of HCoV-associated infections, no multi-center studies have been conducted in Korean children. We aimed to describe the epidem...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-04-01
|
| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.877759/full |
| _version_ | 1831672420312809472 |
|---|---|
| author | Kyo Jin Jo Soo-Han Choi Chi Eun Oh HyeonA Kim Bong Seok Choi Dae Sun Jo Su Eun Park |
| author_facet | Kyo Jin Jo Soo-Han Choi Chi Eun Oh HyeonA Kim Bong Seok Choi Dae Sun Jo Su Eun Park |
| author_sort | Kyo Jin Jo |
| collection | DOAJ |
| description | BackgroundHuman coronaviruses (HCoVs) are associated with upper respiratory tract infections. Although studies have analyzed the clinical and epidemiological characteristics of HCoV-associated infections, no multi-center studies have been conducted in Korean children. We aimed to describe the epidemiology and clinical characteristics of HCoV-associated infection in children.MethodsWe retrospectively reviewed medical records of children in whom HCoVs were detected using multiplex reverse transcriptase-polymerase chain reaction amplification in five centers from January 2015 to December 2019.ResultsOverall, 1,096 patients were enrolled. Among them, 654 (59.7%) patients were male. The median age was 1 year [interquartile range (IQR), 0–2 years]. HCoVs were identified mainly in winter (55.9%). HCoV-229E, HCoV-OC43, and HCoOV-NL63 were detected mainly in winter (70.9, 55.8, and 57.4%, respectively), but HCoV-HKU1 was mainly identified in spring (69.7%). HCoV-OC43 (66.0%) was detected most frequently, followed by HCoV-NL63 (33.3%), and HCoV-229E (7.7%). Two different types of HCoVs were co-detected in 18 samples, namely. Alphacoronavirus-betacoronavirus co-infection (n = 13) and, alphacoronavirus-alphacoronavirus co-infection (n = 5). No betacoronavirus-betacoronavirus co-infection was detected. Patients were diagnosed with upper respiratory tract infection (41.4%), pneumonia (16.6%), acute bronchiolitis (15.5%), non-specific febrile illness (13.1%), croup (7.3%), and acute gastroenteritis (5.1%). There were 832 (75.9%) hospitalized patients with a median duration of hospitalization of 4 days (IQR, 3–5 days); 108 (9.9%) patients needed supplemental oxygen with 37 (3.4%) needing high-flow nasal cannula or mechanical ventilation. There were no deaths.ConclusionHCoV-associated infections exhibit marked seasonality with peaks in winter. Patients with lower respiratory tract infection, a history of prematurity, or underlying chronic diseases may progress to a severe course and may need oxygen therapy. |
| first_indexed | 2024-12-19T23:53:35Z |
| format | Article |
| id | doaj.art-999be31e391d4518bc48d2560ee83931 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-19T23:53:35Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-999be31e391d4518bc48d2560ee839312022-12-21T20:01:05ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-04-011010.3389/fped.2022.877759877759Epidemiology and Clinical Characteristics of Human Coronaviruses-Associated Infections in Children: A Multi-Center StudyKyo Jin Jo0Soo-Han Choi1Chi Eun Oh2HyeonA Kim3Bong Seok Choi4Dae Sun Jo5Su Eun Park6Department of Pediatrics, Pusan National University Children's Hospital, Yangsan, South KoreaDepartment of Pediatrics, Pusan National University Hospital, Busan, South KoreaDepartment of Pediatrics, Kosin University College of Medicine, Busan, South KoreaDepartment of Pediatrics, School of Medicine, Kyungpook National University, Daegu, South KoreaDepartment of Pediatrics, School of Medicine, Kyungpook National University, Daegu, South KoreaDepartment of Pediatrics, Jeonbuk National University Medical School, Jeonju, South KoreaDepartment of Pediatrics, Pusan National University Children's Hospital, Yangsan, South KoreaBackgroundHuman coronaviruses (HCoVs) are associated with upper respiratory tract infections. Although studies have analyzed the clinical and epidemiological characteristics of HCoV-associated infections, no multi-center studies have been conducted in Korean children. We aimed to describe the epidemiology and clinical characteristics of HCoV-associated infection in children.MethodsWe retrospectively reviewed medical records of children in whom HCoVs were detected using multiplex reverse transcriptase-polymerase chain reaction amplification in five centers from January 2015 to December 2019.ResultsOverall, 1,096 patients were enrolled. Among them, 654 (59.7%) patients were male. The median age was 1 year [interquartile range (IQR), 0–2 years]. HCoVs were identified mainly in winter (55.9%). HCoV-229E, HCoV-OC43, and HCoOV-NL63 were detected mainly in winter (70.9, 55.8, and 57.4%, respectively), but HCoV-HKU1 was mainly identified in spring (69.7%). HCoV-OC43 (66.0%) was detected most frequently, followed by HCoV-NL63 (33.3%), and HCoV-229E (7.7%). Two different types of HCoVs were co-detected in 18 samples, namely. Alphacoronavirus-betacoronavirus co-infection (n = 13) and, alphacoronavirus-alphacoronavirus co-infection (n = 5). No betacoronavirus-betacoronavirus co-infection was detected. Patients were diagnosed with upper respiratory tract infection (41.4%), pneumonia (16.6%), acute bronchiolitis (15.5%), non-specific febrile illness (13.1%), croup (7.3%), and acute gastroenteritis (5.1%). There were 832 (75.9%) hospitalized patients with a median duration of hospitalization of 4 days (IQR, 3–5 days); 108 (9.9%) patients needed supplemental oxygen with 37 (3.4%) needing high-flow nasal cannula or mechanical ventilation. There were no deaths.ConclusionHCoV-associated infections exhibit marked seasonality with peaks in winter. Patients with lower respiratory tract infection, a history of prematurity, or underlying chronic diseases may progress to a severe course and may need oxygen therapy.https://www.frontiersin.org/articles/10.3389/fped.2022.877759/fullhuman coronavirusmultiplex polymerase chain reactionchildrenmulti-center studyprognosis |
| spellingShingle | Kyo Jin Jo Soo-Han Choi Chi Eun Oh HyeonA Kim Bong Seok Choi Dae Sun Jo Su Eun Park Epidemiology and Clinical Characteristics of Human Coronaviruses-Associated Infections in Children: A Multi-Center Study Frontiers in Pediatrics human coronavirus multiplex polymerase chain reaction children multi-center study prognosis |
| title | Epidemiology and Clinical Characteristics of Human Coronaviruses-Associated Infections in Children: A Multi-Center Study |
| title_full | Epidemiology and Clinical Characteristics of Human Coronaviruses-Associated Infections in Children: A Multi-Center Study |
| title_fullStr | Epidemiology and Clinical Characteristics of Human Coronaviruses-Associated Infections in Children: A Multi-Center Study |
| title_full_unstemmed | Epidemiology and Clinical Characteristics of Human Coronaviruses-Associated Infections in Children: A Multi-Center Study |
| title_short | Epidemiology and Clinical Characteristics of Human Coronaviruses-Associated Infections in Children: A Multi-Center Study |
| title_sort | epidemiology and clinical characteristics of human coronaviruses associated infections in children a multi center study |
| topic | human coronavirus multiplex polymerase chain reaction children multi-center study prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.877759/full |
| work_keys_str_mv | AT kyojinjo epidemiologyandclinicalcharacteristicsofhumancoronavirusesassociatedinfectionsinchildrenamulticenterstudy AT soohanchoi epidemiologyandclinicalcharacteristicsofhumancoronavirusesassociatedinfectionsinchildrenamulticenterstudy AT chieunoh epidemiologyandclinicalcharacteristicsofhumancoronavirusesassociatedinfectionsinchildrenamulticenterstudy AT hyeonakim epidemiologyandclinicalcharacteristicsofhumancoronavirusesassociatedinfectionsinchildrenamulticenterstudy AT bongseokchoi epidemiologyandclinicalcharacteristicsofhumancoronavirusesassociatedinfectionsinchildrenamulticenterstudy AT daesunjo epidemiologyandclinicalcharacteristicsofhumancoronavirusesassociatedinfectionsinchildrenamulticenterstudy AT sueunpark epidemiologyandclinicalcharacteristicsofhumancoronavirusesassociatedinfectionsinchildrenamulticenterstudy |