Dual-targeting nanomedicine achieves synergistic multimodal therapy for tumor
Abstract Background The poor targeting delivery efficiency and limited efficacy of single therapeutic approach have consistently posed significant challenges in tumor management. Results In this research, we have conceived and synthesized a dual-targeting nanodrug delivery system denoted as PDA-DEM-...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Cancer Nanotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12645-023-00244-0 |
| _version_ | 1827382418857787392 |
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| author | Weidong Zhang Liang Dai Na Wang Yunhe Liu Zining Hao Yaqian He Song Ni Yimin Wang Dawei Gao |
| author_facet | Weidong Zhang Liang Dai Na Wang Yunhe Liu Zining Hao Yaqian He Song Ni Yimin Wang Dawei Gao |
| author_sort | Weidong Zhang |
| collection | DOAJ |
| description | Abstract Background The poor targeting delivery efficiency and limited efficacy of single therapeutic approach have consistently posed significant challenges in tumor management. Results In this research, we have conceived and synthesized a dual-targeting nanodrug delivery system denoted as PDA-DEM-Fe3O4@M, which incorporates a polydopamine nanoparticle (PDA) with photothermal properties, diethyl maleate (DEM) as a chemotherapy agent accelerating tumor apoptosis, iron oxide nanoparticles (Fe3O4) eliciting magnetic targeting effects, and tumor cell membranes (M) contributing to homologous targeting capabilities. The synergistic effect of PDA-induced photothermal therapy and DEM-mediated chemotherapy has been demonstrated in this study to exert a robust inhibitory and cytotoxic influence on tumor cells. Additionally, the biocompatibility of this system has also been demonstrated. Conclusions Through the synergistic effects of PDA’s photothermal therapy and DEM’s chemotherapy, this system demonstrated excellent inhibition and killing effects on tumor cells. Furthermore, we established its excellent biological safety profile. This study demonstrated the potential of this nanomaterial for clinical application in tumor therapy. |
| first_indexed | 2024-03-08T14:19:21Z |
| format | Article |
| id | doaj.art-999d3dc6f04147578951a26662e3a312 |
| institution | Directory Open Access Journal |
| issn | 1868-6958 1868-6966 |
| language | English |
| last_indexed | 2024-03-08T14:19:21Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Nanotechnology |
| spelling | doaj.art-999d3dc6f04147578951a26662e3a3122024-01-14T12:12:03ZengBMCCancer Nanotechnology1868-69581868-69662024-01-0115111110.1186/s12645-023-00244-0Dual-targeting nanomedicine achieves synergistic multimodal therapy for tumorWeidong Zhang0Liang Dai1Na Wang2Yunhe Liu3Zining Hao4Yaqian He5Song Ni6Yimin Wang7Dawei Gao8The First Hospital of QinhuangdaoThe First Hospital of QinhuangdaoThe First Hospital of QinhuangdaoNational Clinical Research Center for Cancer/Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical CollegeState Key Laboratory of Metastable Materials Science and Technology, Nano-Biotechnology Key Lab of Hebei Province, Applying Chemistry Key Lab of Hebei Province, Heavy Metal Deep-Remediation in Water and Resource Reuse Key Lab of Hebei, Yanshan UniversityState Key Laboratory of Metastable Materials Science and Technology, Nano-Biotechnology Key Lab of Hebei Province, Applying Chemistry Key Lab of Hebei Province, Heavy Metal Deep-Remediation in Water and Resource Reuse Key Lab of Hebei, Yanshan UniversityNational Clinical Research Center for Cancer/Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical CollegeThe First Hospital of QinhuangdaoState Key Laboratory of Metastable Materials Science and Technology, Nano-Biotechnology Key Lab of Hebei Province, Applying Chemistry Key Lab of Hebei Province, Heavy Metal Deep-Remediation in Water and Resource Reuse Key Lab of Hebei, Yanshan UniversityAbstract Background The poor targeting delivery efficiency and limited efficacy of single therapeutic approach have consistently posed significant challenges in tumor management. Results In this research, we have conceived and synthesized a dual-targeting nanodrug delivery system denoted as PDA-DEM-Fe3O4@M, which incorporates a polydopamine nanoparticle (PDA) with photothermal properties, diethyl maleate (DEM) as a chemotherapy agent accelerating tumor apoptosis, iron oxide nanoparticles (Fe3O4) eliciting magnetic targeting effects, and tumor cell membranes (M) contributing to homologous targeting capabilities. The synergistic effect of PDA-induced photothermal therapy and DEM-mediated chemotherapy has been demonstrated in this study to exert a robust inhibitory and cytotoxic influence on tumor cells. Additionally, the biocompatibility of this system has also been demonstrated. Conclusions Through the synergistic effects of PDA’s photothermal therapy and DEM’s chemotherapy, this system demonstrated excellent inhibition and killing effects on tumor cells. Furthermore, we established its excellent biological safety profile. This study demonstrated the potential of this nanomaterial for clinical application in tumor therapy.https://doi.org/10.1186/s12645-023-00244-0Tumor therapyTargeting deliveryPhotothermal therapySynergistic effect |
| spellingShingle | Weidong Zhang Liang Dai Na Wang Yunhe Liu Zining Hao Yaqian He Song Ni Yimin Wang Dawei Gao Dual-targeting nanomedicine achieves synergistic multimodal therapy for tumor Cancer Nanotechnology Tumor therapy Targeting delivery Photothermal therapy Synergistic effect |
| title | Dual-targeting nanomedicine achieves synergistic multimodal therapy for tumor |
| title_full | Dual-targeting nanomedicine achieves synergistic multimodal therapy for tumor |
| title_fullStr | Dual-targeting nanomedicine achieves synergistic multimodal therapy for tumor |
| title_full_unstemmed | Dual-targeting nanomedicine achieves synergistic multimodal therapy for tumor |
| title_short | Dual-targeting nanomedicine achieves synergistic multimodal therapy for tumor |
| title_sort | dual targeting nanomedicine achieves synergistic multimodal therapy for tumor |
| topic | Tumor therapy Targeting delivery Photothermal therapy Synergistic effect |
| url | https://doi.org/10.1186/s12645-023-00244-0 |
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