Polypseudorotaxanes of Pluronic® F127 with Combinations of α- and β-Cyclodextrins for Topical Formulation of Acyclovir

Polypseudorotaxanes of Pluronic® F127 with Combinations of α- and β-Cyclodextrins for Topical Formulation of Acyclovir

Acyclovir (ACV) is one of the most used antiviral drugs for the treatment of herpes simplex virus infections and other relevant mucosal infections caused by viruses. Nevertheless, the low water solubility of ACV limits both its bioavailability and antiviral performance. The combination of block copo...

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Bibliographic Details
Main Authors: Cristina Di Donato, Rosa Iacovino, Carla Isernia, Gaetano Malgieri, Angela Varela-Garcia, Angel Concheiro, Carmen Alvarez-Lorenzo
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Nanomaterials
Subjects:
Pluronic® F127
cyclodextrins mixture
acyclovir
polypseudorotaxanes
solubilization
controlled release
Online Access:https://www.mdpi.com/2079-4991/10/4/613

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