Profiling the physicochemical and solid state properties of edible Tetracarpidium conophorum oil and its admixtures for drug delivery
Abstract The study is aimed at investigating the functional physicochemical and solid state characteristics of food-grade Tetracarpidium conophorum (T. conophorum) oil for possible application in the pharmaceutical industry for drug delivery. The oil was obtained by cold hexane extraction and its ph...
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2022-08-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100689&lng=en&tlng=en |
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| author | Chukwuebuka Emmanuel Umeyor Faithline Dan-Ejih Amarachukwu Ukamaka Okonkwo Immaculeta Chikamnele Umeyor Anthony Amaechi Attama |
| author_facet | Chukwuebuka Emmanuel Umeyor Faithline Dan-Ejih Amarachukwu Ukamaka Okonkwo Immaculeta Chikamnele Umeyor Anthony Amaechi Attama |
| author_sort | Chukwuebuka Emmanuel Umeyor |
| collection | DOAJ |
| description | Abstract The study is aimed at investigating the functional physicochemical and solid state characteristics of food-grade Tetracarpidium conophorum (T. conophorum) oil for possible application in the pharmaceutical industry for drug delivery. The oil was obtained by cold hexane extraction and its physicochemical properties including viscosity, pH, peroxide, acid, and thiobarbituric acid values, nutrient content, and fatty acid profile were determined. Admixtures of the oil with Softisan®154, a hydrogenated solid lipid from palm oil, were prepared to obtain matrices which were evaluated by differential scanning calorimetry, fourier-transform infrared spectroscopy, and x-ray diffractometry. Data from the study showed that T. conophorum oil had Newtonian flow behaviour, acidic pH, insignificant presence of hyperperoxides and malondialdehyde, contains minerals including calcium, magnesium, zinc, copper, manganese, iron, selenium, and potassium, vitamins including niacin (B3), thiamine (B1), cyanocobalamine (B12), ascorbic acid (C), and tocopherol (E), and long-chain saturated and unsaturated fatty acids including n-hexadecanoic acid, 9(Z)-octadecenoic acid, and cis-13-octadecenoic acid. The lipid matrices had low crystallinity and enthalpy values with increased amorphicity, and showed no destructive intermolecular interaction or incompatibility between T. conophorum oil and Softisan® 154. In conclusion, the results have shown that, in addition to T. conophorum oil being useful as food, it will also be an important excipient for the development of novel, safe, and effective lipid-based drug delivery systems. |
| first_indexed | 2024-04-13T18:29:42Z |
| format | Article |
| id | doaj.art-999e45aeae0e49eb8ddaf6c2bc925402 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-04-13T18:29:42Z |
| publishDate | 2022-08-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-999e45aeae0e49eb8ddaf6c2bc9254022022-12-22T02:35:09ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902022-08-015810.1590/s2175-97902022e191133Profiling the physicochemical and solid state properties of edible Tetracarpidium conophorum oil and its admixtures for drug deliveryChukwuebuka Emmanuel Umeyorhttps://orcid.org/0000-0001-8674-0867Faithline Dan-EjihAmarachukwu Ukamaka OkonkwoImmaculeta Chikamnele UmeyorAnthony Amaechi AttamaAbstract The study is aimed at investigating the functional physicochemical and solid state characteristics of food-grade Tetracarpidium conophorum (T. conophorum) oil for possible application in the pharmaceutical industry for drug delivery. The oil was obtained by cold hexane extraction and its physicochemical properties including viscosity, pH, peroxide, acid, and thiobarbituric acid values, nutrient content, and fatty acid profile were determined. Admixtures of the oil with Softisan®154, a hydrogenated solid lipid from palm oil, were prepared to obtain matrices which were evaluated by differential scanning calorimetry, fourier-transform infrared spectroscopy, and x-ray diffractometry. Data from the study showed that T. conophorum oil had Newtonian flow behaviour, acidic pH, insignificant presence of hyperperoxides and malondialdehyde, contains minerals including calcium, magnesium, zinc, copper, manganese, iron, selenium, and potassium, vitamins including niacin (B3), thiamine (B1), cyanocobalamine (B12), ascorbic acid (C), and tocopherol (E), and long-chain saturated and unsaturated fatty acids including n-hexadecanoic acid, 9(Z)-octadecenoic acid, and cis-13-octadecenoic acid. The lipid matrices had low crystallinity and enthalpy values with increased amorphicity, and showed no destructive intermolecular interaction or incompatibility between T. conophorum oil and Softisan® 154. In conclusion, the results have shown that, in addition to T. conophorum oil being useful as food, it will also be an important excipient for the development of novel, safe, and effective lipid-based drug delivery systems.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100689&lng=en&tlng=enTetracarpidium conophorum oilSoftisan®154LipidsNutritionalPhysicochemicalDrug delivery |
| spellingShingle | Chukwuebuka Emmanuel Umeyor Faithline Dan-Ejih Amarachukwu Ukamaka Okonkwo Immaculeta Chikamnele Umeyor Anthony Amaechi Attama Profiling the physicochemical and solid state properties of edible Tetracarpidium conophorum oil and its admixtures for drug delivery Brazilian Journal of Pharmaceutical Sciences Tetracarpidium conophorum oil Softisan®154 Lipids Nutritional Physicochemical Drug delivery |
| title | Profiling the physicochemical and solid state properties of edible Tetracarpidium conophorum oil and its admixtures for drug delivery |
| title_full | Profiling the physicochemical and solid state properties of edible Tetracarpidium conophorum oil and its admixtures for drug delivery |
| title_fullStr | Profiling the physicochemical and solid state properties of edible Tetracarpidium conophorum oil and its admixtures for drug delivery |
| title_full_unstemmed | Profiling the physicochemical and solid state properties of edible Tetracarpidium conophorum oil and its admixtures for drug delivery |
| title_short | Profiling the physicochemical and solid state properties of edible Tetracarpidium conophorum oil and its admixtures for drug delivery |
| title_sort | profiling the physicochemical and solid state properties of edible tetracarpidium conophorum oil and its admixtures for drug delivery |
| topic | Tetracarpidium conophorum oil Softisan®154 Lipids Nutritional Physicochemical Drug delivery |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100689&lng=en&tlng=en |
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