Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance
Arastehfar et al. show that macrophage-engulfed cells of fungal pathogen Candida glabrata exhibit multidrug tolerance and increased survival in the presence of cidal antifungal drugs, forming a reservoir from which drug-resistant mutants emerge
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36882-6 |
| _version_ | 1827983441152442368 |
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| author | Amir Arastehfar Farnaz Daneshnia Nathaly Cabrera Suyapa Penalva-Lopez Jansy Sarathy Matthew Zimmerman Erika Shor David S. Perlin |
| author_facet | Amir Arastehfar Farnaz Daneshnia Nathaly Cabrera Suyapa Penalva-Lopez Jansy Sarathy Matthew Zimmerman Erika Shor David S. Perlin |
| author_sort | Amir Arastehfar |
| collection | DOAJ |
| description | Arastehfar et al. show that macrophage-engulfed cells of fungal pathogen Candida glabrata exhibit multidrug tolerance and increased survival in the presence of cidal antifungal drugs, forming a reservoir from which drug-resistant mutants emerge |
| first_indexed | 2024-04-09T22:48:25Z |
| format | Article |
| id | doaj.art-999fd011484c4d0a8e9b68036ec283e0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:48:25Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-999fd011484c4d0a8e9b68036ec283e02023-03-22T11:43:58ZengNature PortfolioNature Communications2041-17232023-03-0114111410.1038/s41467-023-36882-6Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistanceAmir Arastehfar0Farnaz Daneshnia1Nathaly Cabrera2Suyapa Penalva-Lopez3Jansy Sarathy4Matthew Zimmerman5Erika Shor6David S. Perlin7Center for Discovery and Innovation, Hackensack Meridian HealthCenter for Discovery and Innovation, Hackensack Meridian HealthCenter for Discovery and Innovation, Hackensack Meridian HealthCenter for Discovery and Innovation, Hackensack Meridian HealthCenter for Discovery and Innovation, Hackensack Meridian HealthCenter for Discovery and Innovation, Hackensack Meridian HealthCenter for Discovery and Innovation, Hackensack Meridian HealthCenter for Discovery and Innovation, Hackensack Meridian HealthArastehfar et al. show that macrophage-engulfed cells of fungal pathogen Candida glabrata exhibit multidrug tolerance and increased survival in the presence of cidal antifungal drugs, forming a reservoir from which drug-resistant mutants emergehttps://doi.org/10.1038/s41467-023-36882-6 |
| spellingShingle | Amir Arastehfar Farnaz Daneshnia Nathaly Cabrera Suyapa Penalva-Lopez Jansy Sarathy Matthew Zimmerman Erika Shor David S. Perlin Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance Nature Communications |
| title | Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance |
| title_full | Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance |
| title_fullStr | Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance |
| title_full_unstemmed | Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance |
| title_short | Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance |
| title_sort | macrophage internalization creates a multidrug tolerant fungal persister reservoir and facilitates the emergence of drug resistance |
| url | https://doi.org/10.1038/s41467-023-36882-6 |
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