Atheroprotective effects of methotrexate via the inhibition of YAP/TAZ under disturbed flow

Atheroprotective effects of methotrexate via the inhibition of YAP/TAZ under disturbed flow

Abstract Background Atherosclerosis preferentially develops in regions of disturbed flow (DF). Emerging evidence indicates that yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), which are both effectors of the Hippo pathway, sense different blood flow patter...

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Main Authors: Dandan Liu, Hang Lv, Qi Liu, Yanli Sun, Shenglong Hou, Lu Zhang, Mengyue Yang, Baihe Han, Gang wang, Xuedong Wang, Wenjuan Du, Honggang Nie, Ruoxi Zhang, Xingtao Huang, Jingbo Hou, Bo Yu
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Translational Medicine
Subjects:
Methotrexate
Human umbilical vein endothelial cells
YAP/TAZ
Shear stress
AMP-dependent kinase
Online Access:http://link.springer.com/article/10.1186/s12967-019-02135-8

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