Increased circulating adiponectin is an independent disease activity marker in patients with rheumatoid arthritis: A cross-sectional study using the KURAMA database.
OBJECTIVE:To clarify the relationship among serum adiponectin, body composition, current disease activity and therapeutics of rheumatoid arthritis (RA). METHODS:We conducted a cross-sectional study in RA patients under treatment with agents including biological disease-modifying antirheumatic drugs...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0229998 |
| _version_ | 1818678396381560832 |
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| author | Hiroto Minamino Masao Katsushima Tamami Yoshida Motomu Hashimoto Yoshihito Fujita Mirei Shirakashi Wataru Yamamoto Kosaku Murakami Koichi Murata Kohei Nishitani Masao Tanaka Hiromu Ito Nobuya Inagaki Shuichi Matsuda |
| author_facet | Hiroto Minamino Masao Katsushima Tamami Yoshida Motomu Hashimoto Yoshihito Fujita Mirei Shirakashi Wataru Yamamoto Kosaku Murakami Koichi Murata Kohei Nishitani Masao Tanaka Hiromu Ito Nobuya Inagaki Shuichi Matsuda |
| author_sort | Hiroto Minamino |
| collection | DOAJ |
| description | OBJECTIVE:To clarify the relationship among serum adiponectin, body composition, current disease activity and therapeutics of rheumatoid arthritis (RA). METHODS:We conducted a cross-sectional study in RA patients under treatment with agents including biological disease-modifying antirheumatic drugs (bDMARDs) and Janus kinase (JAK) inhibitors. A total of 351 subjects from the Kyoto University RA Management Alliance cohort (KURAMA) were enrolled in the analysis. We classified the participants into five body composition groups according to the cut-off points for obesity and visceral fat used in Japan: body mass index (BMI), 18.5 kg/m2 for underweight and 25.0 kg/m2 for obesity, and visceral fat area (VFA), 100 cm2 for visceral adiposity. RESULTS:Classification of body composition revealed that serum adiponectin levels and disease activity score (DAS28-ESR) in the low BMI group were significantly higher than those in the normal and overweight groups. Because both increased serum adiponectin and low BMI were previously reported as poor prognostic factors of RA, we performed multiple regression analysis to determine which factor was correlated with RA disease activity. Serum adiponectin level, but not BMI, was positively associated with DAS28-ESR (estimate = 0.0127, p = 0.0258). Subanalysis also showed that the use of bDMARD or JAK inhibitor did not have an obvious influence on circulating adiponectin. CONCLUSIONS:Classification of body composition and multiple regression analysis revealed a positive and independent correlation between serum adiponectin and DAS28-ESR in Japanese RA patients. Thus, serum adiponectin may be an important marker reflecting high disease activity of RA regardless of current medications. |
| first_indexed | 2024-12-17T09:14:36Z |
| format | Article |
| id | doaj.art-99a0ef3bd1f54dba8ce00988b285e0ad |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T09:14:36Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-99a0ef3bd1f54dba8ce00988b285e0ad2022-12-21T21:55:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01153e022999810.1371/journal.pone.0229998Increased circulating adiponectin is an independent disease activity marker in patients with rheumatoid arthritis: A cross-sectional study using the KURAMA database.Hiroto MinaminoMasao KatsushimaTamami YoshidaMotomu HashimotoYoshihito FujitaMirei ShirakashiWataru YamamotoKosaku MurakamiKoichi MurataKohei NishitaniMasao TanakaHiromu ItoNobuya InagakiShuichi MatsudaOBJECTIVE:To clarify the relationship among serum adiponectin, body composition, current disease activity and therapeutics of rheumatoid arthritis (RA). METHODS:We conducted a cross-sectional study in RA patients under treatment with agents including biological disease-modifying antirheumatic drugs (bDMARDs) and Janus kinase (JAK) inhibitors. A total of 351 subjects from the Kyoto University RA Management Alliance cohort (KURAMA) were enrolled in the analysis. We classified the participants into five body composition groups according to the cut-off points for obesity and visceral fat used in Japan: body mass index (BMI), 18.5 kg/m2 for underweight and 25.0 kg/m2 for obesity, and visceral fat area (VFA), 100 cm2 for visceral adiposity. RESULTS:Classification of body composition revealed that serum adiponectin levels and disease activity score (DAS28-ESR) in the low BMI group were significantly higher than those in the normal and overweight groups. Because both increased serum adiponectin and low BMI were previously reported as poor prognostic factors of RA, we performed multiple regression analysis to determine which factor was correlated with RA disease activity. Serum adiponectin level, but not BMI, was positively associated with DAS28-ESR (estimate = 0.0127, p = 0.0258). Subanalysis also showed that the use of bDMARD or JAK inhibitor did not have an obvious influence on circulating adiponectin. CONCLUSIONS:Classification of body composition and multiple regression analysis revealed a positive and independent correlation between serum adiponectin and DAS28-ESR in Japanese RA patients. Thus, serum adiponectin may be an important marker reflecting high disease activity of RA regardless of current medications.https://doi.org/10.1371/journal.pone.0229998 |
| spellingShingle | Hiroto Minamino Masao Katsushima Tamami Yoshida Motomu Hashimoto Yoshihito Fujita Mirei Shirakashi Wataru Yamamoto Kosaku Murakami Koichi Murata Kohei Nishitani Masao Tanaka Hiromu Ito Nobuya Inagaki Shuichi Matsuda Increased circulating adiponectin is an independent disease activity marker in patients with rheumatoid arthritis: A cross-sectional study using the KURAMA database. PLoS ONE |
| title | Increased circulating adiponectin is an independent disease activity marker in patients with rheumatoid arthritis: A cross-sectional study using the KURAMA database. |
| title_full | Increased circulating adiponectin is an independent disease activity marker in patients with rheumatoid arthritis: A cross-sectional study using the KURAMA database. |
| title_fullStr | Increased circulating adiponectin is an independent disease activity marker in patients with rheumatoid arthritis: A cross-sectional study using the KURAMA database. |
| title_full_unstemmed | Increased circulating adiponectin is an independent disease activity marker in patients with rheumatoid arthritis: A cross-sectional study using the KURAMA database. |
| title_short | Increased circulating adiponectin is an independent disease activity marker in patients with rheumatoid arthritis: A cross-sectional study using the KURAMA database. |
| title_sort | increased circulating adiponectin is an independent disease activity marker in patients with rheumatoid arthritis a cross sectional study using the kurama database |
| url | https://doi.org/10.1371/journal.pone.0229998 |
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