A small non-interface surface epitope in human IL18 mediates the dynamics and self-assembly of IL18-IL18BP heterodimers

A small non-interface surface epitope in human IL18 mediates the dynamics and self-assembly of IL18-IL18BP heterodimers

Interleukin 18 (IL18) is a pro-inflammatory cytokine that modulates innate and adaptive immune responses. IL18 activity is tightly controlled by the constitutively secreted IL18 binding protein (IL18BP). PDB structures of human IL18 showed that a short stretch of amino acids between 68 and 81 adopte...

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Bibliographic Details
Main Authors: Yılmaz Yücehan Yazıcı, Serkan Belkaya, Emel Timucin
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Interleukin-18
Interleukin-18 binding protein
Protein-protein interactions
Self-assembly
Molecular dynamics simulations
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023002349

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