Reprogramming alternative macrophage polarization by GATM-mediated endogenous creatine synthesis: A potential target for HDM-induced asthma treatment

Reprogramming alternative macrophage polarization by GATM-mediated endogenous creatine synthesis: A potential target for HDM-induced asthma treatment

Cellular energy metabolism plays a crucial role in the regulation of macrophage polarization and in the execution of immune functions. A recent study showed that Slc6a8-mediated creatine uptake from exogenous supplementation modulates macrophage polarization, yet little is known about the role of th...

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Bibliographic Details
Main Authors:	Li Yu, Lingwei Wang, Guang Hu, Laibin Ren, Chen Qiu, Shun Li, Xiaohui Zhou, Shanze Chen, Rongchang Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-09-01
Series:	Frontiers in Immunology
Subjects:	macrophage polarization creatine glycine amidinotransferase (GATM) asthma
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.937331/full

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