Elevated Serum Procalcitonin to Predict Severity and Prognosis of Extensive Burns
Purpose To analyze the factors affecting the elevation of serum procalcitonin (PCT) in patients with extensive burns, and explore its potential value in evaluating the severity and prognosis. Methods Clinical data of 139 patients with extensive burns admitted to our burn center from January 2014 to...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-07-01
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| Series: | Journal of Investigative Surgery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08941939.2022.2073489 |
| _version_ | 1797684485859311616 |
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| author | Zhaoxing Liu Dawei Li Xinzhu Liu Bohan Zhang Yu Zang Jinglong Ma Wen Zhang Yuezeng Niu Chuanan Shen |
| author_facet | Zhaoxing Liu Dawei Li Xinzhu Liu Bohan Zhang Yu Zang Jinglong Ma Wen Zhang Yuezeng Niu Chuanan Shen |
| author_sort | Zhaoxing Liu |
| collection | DOAJ |
| description | Purpose To analyze the factors affecting the elevation of serum procalcitonin (PCT) in patients with extensive burns, and explore its potential value in evaluating the severity and prognosis. Methods Clinical data of 139 patients with extensive burns admitted to our burn center from January 2014 to December 2019 were retrospectively analyzed. Spearman’s Rank correlation coefficient was used to analyze the factors influencing the elevated PCT levels. The predictive power of PCT for death was evaluated by receiver operating characteristic (ROC) and multiple logistic regression analysis. Results 72 cases exhibited elevated serum PCT concentrations during the shock phase, but none of them had obvious signs of infection. PCT level in the shock phase was positively correlated with burn area, depth, degree of inhalation injury, delay in fluid resuscitation, APACHE II, and SOFA scores. The peak values of PCT during shock and infection phases were significantly higher in the non-survivors than in the survivors. The areas under the ROC curve for predicting death were 0.788 and 0.926, respectively, and 5.4 ng/mL (OR = 5.33) and 8.5 ng/mL (OR = 14.49) were the high-risk thresholds for death prediction. Conclusions Serum PCT level in the shock phase is a potential indicator for evaluating the severity of burns, while the PCT level during the infection period can be used as an early warning indicator for severe systemic infection. High levels of PCT peaks during the shock and infection periods indicate an increased risk of poor prognosis, and targeted treatment is required accordingly. |
| first_indexed | 2024-03-12T00:30:23Z |
| format | Article |
| id | doaj.art-99a4f084656a4b94a1fe7dd2eb95441a |
| institution | Directory Open Access Journal |
| issn | 0894-1939 1521-0553 |
| language | English |
| last_indexed | 2024-03-12T00:30:23Z |
| publishDate | 2022-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj.art-99a4f084656a4b94a1fe7dd2eb95441a2023-09-15T10:21:30ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532022-07-013571510151810.1080/08941939.2022.20734892073489Elevated Serum Procalcitonin to Predict Severity and Prognosis of Extensive BurnsZhaoxing Liu0Dawei Li1Xinzhu Liu2Bohan Zhang3Yu Zang4Jinglong Ma5Wen Zhang6Yuezeng Niu7Chuanan Shen8Department of Burns and Plastic Surgery, The Fourth Medical Center of PLA General HospitalDepartment of Burns and Plastic Surgery, The Fourth Medical Center of PLA General HospitalDepartment of Burns and Plastic Surgery, The Fourth Medical Center of PLA General HospitalDepartment of Burns and Plastic Surgery, The Fourth Medical Center of PLA General HospitalDepartment of Burns and Plastic Surgery, The Fourth Medical Center of PLA General HospitalDepartment of Burns and Plastic Surgery, The Fourth Medical Center of PLA General HospitalDepartment of Burns and Plastic Surgery, The Fourth Medical Center of PLA General HospitalDepartment of Burns and Plastic Surgery, The Fourth Medical Center of PLA General HospitalDepartment of Burns and Plastic Surgery, The Fourth Medical Center of PLA General HospitalPurpose To analyze the factors affecting the elevation of serum procalcitonin (PCT) in patients with extensive burns, and explore its potential value in evaluating the severity and prognosis. Methods Clinical data of 139 patients with extensive burns admitted to our burn center from January 2014 to December 2019 were retrospectively analyzed. Spearman’s Rank correlation coefficient was used to analyze the factors influencing the elevated PCT levels. The predictive power of PCT for death was evaluated by receiver operating characteristic (ROC) and multiple logistic regression analysis. Results 72 cases exhibited elevated serum PCT concentrations during the shock phase, but none of them had obvious signs of infection. PCT level in the shock phase was positively correlated with burn area, depth, degree of inhalation injury, delay in fluid resuscitation, APACHE II, and SOFA scores. The peak values of PCT during shock and infection phases were significantly higher in the non-survivors than in the survivors. The areas under the ROC curve for predicting death were 0.788 and 0.926, respectively, and 5.4 ng/mL (OR = 5.33) and 8.5 ng/mL (OR = 14.49) were the high-risk thresholds for death prediction. Conclusions Serum PCT level in the shock phase is a potential indicator for evaluating the severity of burns, while the PCT level during the infection period can be used as an early warning indicator for severe systemic infection. High levels of PCT peaks during the shock and infection periods indicate an increased risk of poor prognosis, and targeted treatment is required accordingly.http://dx.doi.org/10.1080/08941939.2022.2073489burnprocalcitoninseveritysepsisprognosis |
| spellingShingle | Zhaoxing Liu Dawei Li Xinzhu Liu Bohan Zhang Yu Zang Jinglong Ma Wen Zhang Yuezeng Niu Chuanan Shen Elevated Serum Procalcitonin to Predict Severity and Prognosis of Extensive Burns Journal of Investigative Surgery burn procalcitonin severity sepsis prognosis |
| title | Elevated Serum Procalcitonin to Predict Severity and Prognosis of Extensive Burns |
| title_full | Elevated Serum Procalcitonin to Predict Severity and Prognosis of Extensive Burns |
| title_fullStr | Elevated Serum Procalcitonin to Predict Severity and Prognosis of Extensive Burns |
| title_full_unstemmed | Elevated Serum Procalcitonin to Predict Severity and Prognosis of Extensive Burns |
| title_short | Elevated Serum Procalcitonin to Predict Severity and Prognosis of Extensive Burns |
| title_sort | elevated serum procalcitonin to predict severity and prognosis of extensive burns |
| topic | burn procalcitonin severity sepsis prognosis |
| url | http://dx.doi.org/10.1080/08941939.2022.2073489 |
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