Mycobacterium ulcerans disease in the Middle Belt of Ghana: An 8-year review from six endemic districts
Background: Mycobacterium ulcerans (MU) produces mycolactone toxin when infected Aims and objectives: The aim is to document the clinical and epidemiological features of Mycobacterium ulcerans disease in the Middle Belt of Ghana, and the outcome of treatment. Patients and Methods: Patients with les...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | International Journal of Mycobacteriology |
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| Online Access: | http://www.ijmyco.org/article.asp?issn=2212-5531;year=2015;volume=4;issue=5;spage=10;epage=10;aulast=Adu;type=0 |
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| author | Emmanuel J.K Adu |
| author_facet | Emmanuel J.K Adu |
| author_sort | Emmanuel J.K Adu |
| collection | DOAJ |
| description | Background: Mycobacterium ulcerans (MU) produces mycolactone toxin when infected
Aims and objectives: The aim is to document the clinical and epidemiological features of Mycobacterium ulcerans disease in the Middle Belt of Ghana, and the outcome of treatment.
Patients and Methods: Patients with lesions suspected to be MU disease were screened by community workers. Lesions were confirmed by any of the following: direct smear examination, culture, polymerase chain reaction (PCR), or histopathology.
Patients were treated with rifampicin (10 mg/kg orally) and streptomycin (15 mg/kg im) combination for 8 weeks. Patients selected for surgical treatment included cases where medical treatment had failed, cases presenting late with complications, and recurrent cases.
Results: 258 patients were seen in the Ahafo Ano, Amansie Central, Amansie West, Asunafo, Asutifi, and Upper Denkyira districts of Ghana between 2005 and 2012. Their ages ranged from 1 year 3 months to 98 years, with a mean age of 29.8 (SD 20.4).
The clinical forms of MU disease seen were: papule (0.74%), nodule (1.48%), chronic osteomyelitis (1.48%), contracture (1.48%), oedematous lesion (2.69%), and ulcer (91.85%). Uncommon complications include subluxation of knee joint, salivary gland fistula and Marjolin's ulcer.
The lesions were distributed as follows: head and neck (6.2%), upper limb (23.1%), trunk (1.5%), and lower limb (69.2%).
Conclusion: The use of antibiotics for MU disease has controlled most lesions; however, rare complications requiring reconstructive surgery are emerging. |
| first_indexed | 2024-12-23T05:58:08Z |
| format | Article |
| id | doaj.art-99a55db4a2614958a76d841136604207 |
| institution | Directory Open Access Journal |
| issn | 2212-5531 2212-554X |
| language | English |
| last_indexed | 2024-12-23T05:58:08Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Mycobacteriology |
| spelling | doaj.art-99a55db4a2614958a76d8411366042072022-12-21T17:57:44ZengWolters Kluwer Medknow PublicationsInternational Journal of Mycobacteriology2212-55312212-554X2015-01-0145101010.1016/j.ijmyco.2014.10.012Mycobacterium ulcerans disease in the Middle Belt of Ghana: An 8-year review from six endemic districtsEmmanuel J.K AduBackground: Mycobacterium ulcerans (MU) produces mycolactone toxin when infected Aims and objectives: The aim is to document the clinical and epidemiological features of Mycobacterium ulcerans disease in the Middle Belt of Ghana, and the outcome of treatment. Patients and Methods: Patients with lesions suspected to be MU disease were screened by community workers. Lesions were confirmed by any of the following: direct smear examination, culture, polymerase chain reaction (PCR), or histopathology. Patients were treated with rifampicin (10 mg/kg orally) and streptomycin (15 mg/kg im) combination for 8 weeks. Patients selected for surgical treatment included cases where medical treatment had failed, cases presenting late with complications, and recurrent cases. Results: 258 patients were seen in the Ahafo Ano, Amansie Central, Amansie West, Asunafo, Asutifi, and Upper Denkyira districts of Ghana between 2005 and 2012. Their ages ranged from 1 year 3 months to 98 years, with a mean age of 29.8 (SD 20.4). The clinical forms of MU disease seen were: papule (0.74%), nodule (1.48%), chronic osteomyelitis (1.48%), contracture (1.48%), oedematous lesion (2.69%), and ulcer (91.85%). Uncommon complications include subluxation of knee joint, salivary gland fistula and Marjolin's ulcer. The lesions were distributed as follows: head and neck (6.2%), upper limb (23.1%), trunk (1.5%), and lower limb (69.2%). Conclusion: The use of antibiotics for MU disease has controlled most lesions; however, rare complications requiring reconstructive surgery are emerging.http://www.ijmyco.org/article.asp?issn=2212-5531;year=2015;volume=4;issue=5;spage=10;epage=10;aulast=Adu;type=0Mycobacterium ulceransUlcerContracturesNoduleOedematous lesion |
| spellingShingle | Emmanuel J.K Adu Mycobacterium ulcerans disease in the Middle Belt of Ghana: An 8-year review from six endemic districts International Journal of Mycobacteriology Mycobacterium ulcerans Ulcer Contractures Nodule Oedematous lesion |
| title | Mycobacterium ulcerans disease in the Middle Belt of Ghana: An 8-year review from six endemic districts |
| title_full | Mycobacterium ulcerans disease in the Middle Belt of Ghana: An 8-year review from six endemic districts |
| title_fullStr | Mycobacterium ulcerans disease in the Middle Belt of Ghana: An 8-year review from six endemic districts |
| title_full_unstemmed | Mycobacterium ulcerans disease in the Middle Belt of Ghana: An 8-year review from six endemic districts |
| title_short | Mycobacterium ulcerans disease in the Middle Belt of Ghana: An 8-year review from six endemic districts |
| title_sort | mycobacterium ulcerans disease in the middle belt of ghana an 8 year review from six endemic districts |
| topic | Mycobacterium ulcerans Ulcer Contractures Nodule Oedematous lesion |
| url | http://www.ijmyco.org/article.asp?issn=2212-5531;year=2015;volume=4;issue=5;spage=10;epage=10;aulast=Adu;type=0 |
| work_keys_str_mv | AT emmanueljkadu mycobacteriumulceransdiseaseinthemiddlebeltofghanaan8yearreviewfromsixendemicdistricts |