Protection of UVB-Induced Photoaging by Fuzhuan-Brick Tea Aqueous Extract via MAPKs/Nrf2-Mediated Down-Regulation of MMP-1
Ultraviolet B (UVB) irradiation is viewed as the principal inducer of skin photo-aging, associated with acceleration of collagen degradation and upregulation of matrix metalloproteinases (MMPs). The ethnic groups of southern/western China use Fuzhuan brick-tea (FBT) as a beverage and as a nutritiona...
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| Format: | Article |
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MDPI AG
2018-12-01
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| Series: | Nutrients |
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| Online Access: | http://www.mdpi.com/2072-6643/11/1/60 |
| _version_ | 1811268850022350848 |
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| author | Peijun Zhao Md Badrul Alam Sang-Han Lee |
| author_facet | Peijun Zhao Md Badrul Alam Sang-Han Lee |
| author_sort | Peijun Zhao |
| collection | DOAJ |
| description | Ultraviolet B (UVB) irradiation is viewed as the principal inducer of skin photo-aging, associated with acceleration of collagen degradation and upregulation of matrix metalloproteinases (MMPs). The ethnic groups of southern/western China use Fuzhuan brick-tea (FBT) as a beverage and as a nutritional supplement. In this study, we scrutinized the antagonistic effects of aqueous extract of Fuzhuan-brick tea (FBTA) on skin photo-aging in UVB-exposed human keratinocyte (HaCaT) cells. FBTA exhibited strong antioxidant activity and quenched UVB-induced generation of cellular reactive oxygen species (ROS) without showing any toxicity. FBTA was capable of combating oxidative stress by augmenting messenger RNA (mRNA) and protein levels of both phase I and phase II detoxifying enzymes, especially heme oxygenase 1 (HO-1), by upregulating the nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated pathway in HaCaT cells via the phosphorylation of p38 and extracellular signal-regulated kinase (ERK). FBTA also downregulated the expression of matrix metalloproteinase-1 (MMP-1) while upregulating type I procollagen by modulating Nrf2 signaling in UVB-irradiated HaCaT cells. Collectively, our results show that FBTA might be useful as a functional food while being a good candidate in the development of cosmetic products and medicines for the remedy of UVB-induced skin photo-aging. |
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| id | doaj.art-99a5f0a4ebb54e62a393a14b8444f447 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-04-12T21:30:15Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-99a5f0a4ebb54e62a393a14b8444f4472022-12-22T03:16:04ZengMDPI AGNutrients2072-66432018-12-011116010.3390/nu11010060nu11010060Protection of UVB-Induced Photoaging by Fuzhuan-Brick Tea Aqueous Extract via MAPKs/Nrf2-Mediated Down-Regulation of MMP-1Peijun Zhao0Md Badrul Alam1Sang-Han Lee2Department of Food Science and Biotechnology, Graduate School, Kyungpook National University, Daegu 41566, KoreaDepartment of Food Science and Biotechnology, Graduate School, Kyungpook National University, Daegu 41566, KoreaDepartment of Food Science and Biotechnology, Graduate School, Kyungpook National University, Daegu 41566, KoreaUltraviolet B (UVB) irradiation is viewed as the principal inducer of skin photo-aging, associated with acceleration of collagen degradation and upregulation of matrix metalloproteinases (MMPs). The ethnic groups of southern/western China use Fuzhuan brick-tea (FBT) as a beverage and as a nutritional supplement. In this study, we scrutinized the antagonistic effects of aqueous extract of Fuzhuan-brick tea (FBTA) on skin photo-aging in UVB-exposed human keratinocyte (HaCaT) cells. FBTA exhibited strong antioxidant activity and quenched UVB-induced generation of cellular reactive oxygen species (ROS) without showing any toxicity. FBTA was capable of combating oxidative stress by augmenting messenger RNA (mRNA) and protein levels of both phase I and phase II detoxifying enzymes, especially heme oxygenase 1 (HO-1), by upregulating the nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated pathway in HaCaT cells via the phosphorylation of p38 and extracellular signal-regulated kinase (ERK). FBTA also downregulated the expression of matrix metalloproteinase-1 (MMP-1) while upregulating type I procollagen by modulating Nrf2 signaling in UVB-irradiated HaCaT cells. Collectively, our results show that FBTA might be useful as a functional food while being a good candidate in the development of cosmetic products and medicines for the remedy of UVB-induced skin photo-aging.http://www.mdpi.com/2072-6643/11/1/60anti-oxidantanti-photoagingheme oxygenase-1nuclear factor erythroid 2-related factor 2 (Nrf2)matrix metalloproteinase-1 (MMP-1) |
| spellingShingle | Peijun Zhao Md Badrul Alam Sang-Han Lee Protection of UVB-Induced Photoaging by Fuzhuan-Brick Tea Aqueous Extract via MAPKs/Nrf2-Mediated Down-Regulation of MMP-1 Nutrients anti-oxidant anti-photoaging heme oxygenase-1 nuclear factor erythroid 2-related factor 2 (Nrf2) matrix metalloproteinase-1 (MMP-1) |
| title | Protection of UVB-Induced Photoaging by Fuzhuan-Brick Tea Aqueous Extract via MAPKs/Nrf2-Mediated Down-Regulation of MMP-1 |
| title_full | Protection of UVB-Induced Photoaging by Fuzhuan-Brick Tea Aqueous Extract via MAPKs/Nrf2-Mediated Down-Regulation of MMP-1 |
| title_fullStr | Protection of UVB-Induced Photoaging by Fuzhuan-Brick Tea Aqueous Extract via MAPKs/Nrf2-Mediated Down-Regulation of MMP-1 |
| title_full_unstemmed | Protection of UVB-Induced Photoaging by Fuzhuan-Brick Tea Aqueous Extract via MAPKs/Nrf2-Mediated Down-Regulation of MMP-1 |
| title_short | Protection of UVB-Induced Photoaging by Fuzhuan-Brick Tea Aqueous Extract via MAPKs/Nrf2-Mediated Down-Regulation of MMP-1 |
| title_sort | protection of uvb induced photoaging by fuzhuan brick tea aqueous extract via mapks nrf2 mediated down regulation of mmp 1 |
| topic | anti-oxidant anti-photoaging heme oxygenase-1 nuclear factor erythroid 2-related factor 2 (Nrf2) matrix metalloproteinase-1 (MMP-1) |
| url | http://www.mdpi.com/2072-6643/11/1/60 |
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