Correlation analysis of serum IGF-1 and IL-6 and urinary albumin/creatinine ratio in patients with type 2 diabetic kidney disease
ObjectivesDiabetic kidney disease (DKD) is one of the most common chronic complications in diabetic patients, and there are major limitations in its pathological diagnosis. This study’s objectives were to examine the changes in serum insulin-like growth factor-1 (IGF-1) and interleukin-6 (IL-6) leve...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-12-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1082492/full |
| _version_ | 1811205176483119104 |
|---|---|
| author | Guan-Wen Liu Jiao-E Zeng Lan-Fang Li |
| author_facet | Guan-Wen Liu Jiao-E Zeng Lan-Fang Li |
| author_sort | Guan-Wen Liu |
| collection | DOAJ |
| description | ObjectivesDiabetic kidney disease (DKD) is one of the most common chronic complications in diabetic patients, and there are major limitations in its pathological diagnosis. This study’s objectives were to examine the changes in serum insulin-like growth factor-1 (IGF-1) and interleukin-6 (IL-6) levels in DKD patients with various urinary albumin/creatinine ratio (ACR) and to evaluate the utility of these two biological markers in the clinical diagnosis of the condition.MethodsWe chose 80 type 2 diabetic patients as the experimental group and 20 healthy normal participants as the control group. The experimental group was split into three groups based on the ACR range: diabetes without nephropathy group (ACR < 30 mg/g), microalbuminuric group (30 < ACR < 300 mg/g), and macroalbuminuric group (ACR > 300 mg/g). The levels of serum IL-6 and IGF-1 were assessed in each trial participant.ResultsSerum IGF-1 was higher in the experimental group than in the control group (P < 0.01), and serum IL-6 levels were also higher than in the control group (P < 0.001). In DKD patients, serum levels of IL-6 and IGF-1 tended to rise when ACR levels rose. By Pearson correlation analysis, serum IGF-1 and IL-6 were positively correlated with ACR (r = 0.765 and r = 0.651, all P < 0.001) and negatively correlated with eGFR (r = -0.389 and r = -0.364, all P < 0.01). Additionally, the receiver operating characteristic (ROC) characteristic curve showed that the area under the curve (AUC) values for serum IGF-1 and IL-6 were 0.9056 and 0.7850, respectively, while the AUR value for both combined was 0.9367.ConclusionSerum IGF-1 and IL-6 levels can be used to diagnose DKD, and the combined analysis of these two indicators can improve the sensitivity and specificity of the disease diagnosis. |
| first_indexed | 2024-04-12T03:26:21Z |
| format | Article |
| id | doaj.art-99a667949d3b41bda2dab44862a2f829 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T03:26:21Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-99a667949d3b41bda2dab44862a2f8292022-12-22T03:49:42ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-12-011310.3389/fendo.2022.10824921082492Correlation analysis of serum IGF-1 and IL-6 and urinary albumin/creatinine ratio in patients with type 2 diabetic kidney diseaseGuan-Wen Liu0Jiao-E Zeng1Lan-Fang Li2Department of Endocrinology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, ChinaDepartment of Endocrinology, Jingzhou Cental Hospital, Jingzhou, ChinaDepartment of Endocrinology, Jingzhou Cental Hospital, Jingzhou, ChinaObjectivesDiabetic kidney disease (DKD) is one of the most common chronic complications in diabetic patients, and there are major limitations in its pathological diagnosis. This study’s objectives were to examine the changes in serum insulin-like growth factor-1 (IGF-1) and interleukin-6 (IL-6) levels in DKD patients with various urinary albumin/creatinine ratio (ACR) and to evaluate the utility of these two biological markers in the clinical diagnosis of the condition.MethodsWe chose 80 type 2 diabetic patients as the experimental group and 20 healthy normal participants as the control group. The experimental group was split into three groups based on the ACR range: diabetes without nephropathy group (ACR < 30 mg/g), microalbuminuric group (30 < ACR < 300 mg/g), and macroalbuminuric group (ACR > 300 mg/g). The levels of serum IL-6 and IGF-1 were assessed in each trial participant.ResultsSerum IGF-1 was higher in the experimental group than in the control group (P < 0.01), and serum IL-6 levels were also higher than in the control group (P < 0.001). In DKD patients, serum levels of IL-6 and IGF-1 tended to rise when ACR levels rose. By Pearson correlation analysis, serum IGF-1 and IL-6 were positively correlated with ACR (r = 0.765 and r = 0.651, all P < 0.001) and negatively correlated with eGFR (r = -0.389 and r = -0.364, all P < 0.01). Additionally, the receiver operating characteristic (ROC) characteristic curve showed that the area under the curve (AUC) values for serum IGF-1 and IL-6 were 0.9056 and 0.7850, respectively, while the AUR value for both combined was 0.9367.ConclusionSerum IGF-1 and IL-6 levels can be used to diagnose DKD, and the combined analysis of these two indicators can improve the sensitivity and specificity of the disease diagnosis.https://www.frontiersin.org/articles/10.3389/fendo.2022.1082492/fullinsulin-like growth factor-1IL-6diabetic kidney diseasediabetes mellitusurinary albumin/creatinine ratio |
| spellingShingle | Guan-Wen Liu Jiao-E Zeng Lan-Fang Li Correlation analysis of serum IGF-1 and IL-6 and urinary albumin/creatinine ratio in patients with type 2 diabetic kidney disease Frontiers in Endocrinology insulin-like growth factor-1 IL-6 diabetic kidney disease diabetes mellitus urinary albumin/creatinine ratio |
| title | Correlation analysis of serum IGF-1 and IL-6 and urinary albumin/creatinine ratio in patients with type 2 diabetic kidney disease |
| title_full | Correlation analysis of serum IGF-1 and IL-6 and urinary albumin/creatinine ratio in patients with type 2 diabetic kidney disease |
| title_fullStr | Correlation analysis of serum IGF-1 and IL-6 and urinary albumin/creatinine ratio in patients with type 2 diabetic kidney disease |
| title_full_unstemmed | Correlation analysis of serum IGF-1 and IL-6 and urinary albumin/creatinine ratio in patients with type 2 diabetic kidney disease |
| title_short | Correlation analysis of serum IGF-1 and IL-6 and urinary albumin/creatinine ratio in patients with type 2 diabetic kidney disease |
| title_sort | correlation analysis of serum igf 1 and il 6 and urinary albumin creatinine ratio in patients with type 2 diabetic kidney disease |
| topic | insulin-like growth factor-1 IL-6 diabetic kidney disease diabetes mellitus urinary albumin/creatinine ratio |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1082492/full |
| work_keys_str_mv | AT guanwenliu correlationanalysisofserumigf1andil6andurinaryalbumincreatinineratioinpatientswithtype2diabetickidneydisease AT jiaoezeng correlationanalysisofserumigf1andil6andurinaryalbumincreatinineratioinpatientswithtype2diabetickidneydisease AT lanfangli correlationanalysisofserumigf1andil6andurinaryalbumincreatinineratioinpatientswithtype2diabetickidneydisease |