Prevention of paralytic ileus utilizing alvimopan following spine surgery
Postoperative ileus affects a substantial proportion of patients undergoing elective spine surgery, especially in cases of spinal deformity correction and where an anterior lumbar approach is utilized. Though the first line of treatment for postoperative ileus is conservative management, recent adva...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Open Medical Publishing
2015-09-01
|
| Series: | Orthopedic Reviews |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/or/article/view/6087 |
| _version_ | 1818938515994443776 |
|---|---|
| author | Kalpit N. Shah Gregory Waryasz J. Mason DePasse Alan H. Daniels |
| author_facet | Kalpit N. Shah Gregory Waryasz J. Mason DePasse Alan H. Daniels |
| author_sort | Kalpit N. Shah |
| collection | DOAJ |
| description | Postoperative ileus affects a substantial proportion of patients undergoing elective spine surgery, especially in cases of spinal deformity correction and where an anterior lumbar approach is utilized. Though the first line of treatment for postoperative ileus is conservative management, recent advances in pharmacology have yielded promising options for both treatment and prevention. We report a case of a patient who underwent a two-stage posterior spinal fusion. The patient suffered with a severe, prolonged ileus after her initial surgery. To prevent ileus following her second spinal surgery, alvimopan (a μ-opioid receptor antagonist) was administered and she had a rapid return of bowel function with no signs of ileus. Alvimopan, has been shown to reduce the rate of ileus in colorectal surgery patients, and may be useful for preventing ileus in high-risk orthopedic and spine surgery patients, although prospective studies will be needed to test this hypothesis. |
| first_indexed | 2024-12-20T06:09:05Z |
| format | Article |
| id | doaj.art-99a68d1aac794b388cb2b73960fce55c |
| institution | Directory Open Access Journal |
| issn | 2035-8237 2035-8164 |
| language | English |
| last_indexed | 2024-12-20T06:09:05Z |
| publishDate | 2015-09-01 |
| publisher | Open Medical Publishing |
| record_format | Article |
| series | Orthopedic Reviews |
| spelling | doaj.art-99a68d1aac794b388cb2b73960fce55c2022-12-21T19:50:45ZengOpen Medical PublishingOrthopedic Reviews2035-82372035-81642015-09-017310.4081/or.2015.60873185Prevention of paralytic ileus utilizing alvimopan following spine surgeryKalpit N. Shah0Gregory Waryasz1J. Mason DePasse2Alan H. Daniels3Department of Orthopedic Surgery, Adult Spinal Deformity Service, Brown University Alpert Medical School, Rhode Island Hospital, Providence, RIDepartment of Orthopedic Surgery, Adult Spinal Deformity Service, Brown University Alpert Medical School, Rhode Island Hospital, Providence, RIDepartment of Orthopedic Surgery, Adult Spinal Deformity Service, Brown University Alpert Medical School, Rhode Island Hospital, Providence, RIDepartment of Orthopedic Surgery, Adult Spinal Deformity Service, Brown University Alpert Medical School, Rhode Island Hospital, Providence, RIPostoperative ileus affects a substantial proportion of patients undergoing elective spine surgery, especially in cases of spinal deformity correction and where an anterior lumbar approach is utilized. Though the first line of treatment for postoperative ileus is conservative management, recent advances in pharmacology have yielded promising options for both treatment and prevention. We report a case of a patient who underwent a two-stage posterior spinal fusion. The patient suffered with a severe, prolonged ileus after her initial surgery. To prevent ileus following her second spinal surgery, alvimopan (a μ-opioid receptor antagonist) was administered and she had a rapid return of bowel function with no signs of ileus. Alvimopan, has been shown to reduce the rate of ileus in colorectal surgery patients, and may be useful for preventing ileus in high-risk orthopedic and spine surgery patients, although prospective studies will be needed to test this hypothesis.http://www.pagepress.org/journals/index.php/or/article/view/6087Spine surgeryileuspost operative management |
| spellingShingle | Kalpit N. Shah Gregory Waryasz J. Mason DePasse Alan H. Daniels Prevention of paralytic ileus utilizing alvimopan following spine surgery Orthopedic Reviews Spine surgery ileus post operative management |
| title | Prevention of paralytic ileus utilizing alvimopan following spine surgery |
| title_full | Prevention of paralytic ileus utilizing alvimopan following spine surgery |
| title_fullStr | Prevention of paralytic ileus utilizing alvimopan following spine surgery |
| title_full_unstemmed | Prevention of paralytic ileus utilizing alvimopan following spine surgery |
| title_short | Prevention of paralytic ileus utilizing alvimopan following spine surgery |
| title_sort | prevention of paralytic ileus utilizing alvimopan following spine surgery |
| topic | Spine surgery ileus post operative management |
| url | http://www.pagepress.org/journals/index.php/or/article/view/6087 |
| work_keys_str_mv | AT kalpitnshah preventionofparalyticileusutilizingalvimopanfollowingspinesurgery AT gregorywaryasz preventionofparalyticileusutilizingalvimopanfollowingspinesurgery AT jmasondepasse preventionofparalyticileusutilizingalvimopanfollowingspinesurgery AT alanhdaniels preventionofparalyticileusutilizingalvimopanfollowingspinesurgery |