Dynamics of Hepatitis B Virus Pregenomic RNA in Chronic Hepatitis B Patients With Antiviral Therapy Over 9 Years
Serum hepatitis B virus pregenomic RNA (HBV pgRNA) is a potential biomarker that is correlated with covalently closed circular DNA. The long-term dynamics of HBV pgRNA in patients with chronic hepatitis B need to be explored. One hundred naïve nucleos(t)ide analog-treated patients with chronic hepat...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-04-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.851717/full |
| _version_ | 1818015524221616128 |
|---|---|
| author | Jiali Pan Yu Tian Jinghang Xu Hao Luo Ning Tan Yifan Han Qian Kang Hongyu Chen Yuqing Yang Xiaoyuan Xu |
| author_facet | Jiali Pan Yu Tian Jinghang Xu Hao Luo Ning Tan Yifan Han Qian Kang Hongyu Chen Yuqing Yang Xiaoyuan Xu |
| author_sort | Jiali Pan |
| collection | DOAJ |
| description | Serum hepatitis B virus pregenomic RNA (HBV pgRNA) is a potential biomarker that is correlated with covalently closed circular DNA. The long-term dynamics of HBV pgRNA in patients with chronic hepatitis B need to be explored. One hundred naïve nucleos(t)ide analog-treated patients with chronic hepatitis B were enrolled to analyze the dynamics of HBV pgRNA over 9 years. The positive rates of HBV pgRNAs declined gradually and showed biphasic kinetics. Serum HBV pgRNA levels in patients treated with entecavir became negative later than those treated with adefovir or lamivudine. Patients who remain positive for HBV pgRNA after 9 years of treatment may have higher viral transcription efficiencies. The reverse transcription efficiency of hepatitis B e-antigen (HBeAg)-positive patients was higher than that of HBeAg-negative patients at baseline and showed no difference after 24-week nucleos(t)ide analog treatment. The trajectory of serum HBV pgRNA-negative transformation differs in patients with different characteristics. Long-term dynamic monitoring of serum HBV pgRNA levels has significance in hepatitis B treatment. |
| first_indexed | 2024-04-14T06:58:19Z |
| format | Article |
| id | doaj.art-99a74b7c877d4b8d9a627ae66cae6bba |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-14T06:58:19Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-99a74b7c877d4b8d9a627ae66cae6bba2022-12-22T02:06:49ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-04-01910.3389/fmed.2022.851717851717Dynamics of Hepatitis B Virus Pregenomic RNA in Chronic Hepatitis B Patients With Antiviral Therapy Over 9 YearsJiali Pan0Yu Tian1Jinghang Xu2Hao Luo3Ning Tan4Yifan Han5Qian Kang6Hongyu Chen7Yuqing Yang8Xiaoyuan Xu9Department of Infectious Diseases, Peking University First Hospital, Beijing, ChinaDepartment of Gastroenterology, Peking University First Hospital, Beijing, ChinaDepartment of Infectious Diseases, Peking University First Hospital, Beijing, ChinaDepartment of Gastroenterology, National Center of Gerontology, Beijing Hospital, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Infectious Diseases, Peking University First Hospital, Beijing, ChinaDepartment of Infectious Diseases, Peking University First Hospital, Beijing, ChinaDepartment of Infectious Diseases, Peking University First Hospital, Beijing, ChinaDepartment of Infectious Diseases, Peking University First Hospital, Beijing, ChinaDepartment of Infectious Diseases, Peking University First Hospital, Beijing, ChinaDepartment of Infectious Diseases, Peking University First Hospital, Beijing, ChinaSerum hepatitis B virus pregenomic RNA (HBV pgRNA) is a potential biomarker that is correlated with covalently closed circular DNA. The long-term dynamics of HBV pgRNA in patients with chronic hepatitis B need to be explored. One hundred naïve nucleos(t)ide analog-treated patients with chronic hepatitis B were enrolled to analyze the dynamics of HBV pgRNA over 9 years. The positive rates of HBV pgRNAs declined gradually and showed biphasic kinetics. Serum HBV pgRNA levels in patients treated with entecavir became negative later than those treated with adefovir or lamivudine. Patients who remain positive for HBV pgRNA after 9 years of treatment may have higher viral transcription efficiencies. The reverse transcription efficiency of hepatitis B e-antigen (HBeAg)-positive patients was higher than that of HBeAg-negative patients at baseline and showed no difference after 24-week nucleos(t)ide analog treatment. The trajectory of serum HBV pgRNA-negative transformation differs in patients with different characteristics. Long-term dynamic monitoring of serum HBV pgRNA levels has significance in hepatitis B treatment.https://www.frontiersin.org/articles/10.3389/fmed.2022.851717/fullchronic hepatitis BPgRNAhepatitis B virusdynamicstranscription |
| spellingShingle | Jiali Pan Yu Tian Jinghang Xu Hao Luo Ning Tan Yifan Han Qian Kang Hongyu Chen Yuqing Yang Xiaoyuan Xu Dynamics of Hepatitis B Virus Pregenomic RNA in Chronic Hepatitis B Patients With Antiviral Therapy Over 9 Years Frontiers in Medicine chronic hepatitis B PgRNA hepatitis B virus dynamics transcription |
| title | Dynamics of Hepatitis B Virus Pregenomic RNA in Chronic Hepatitis B Patients With Antiviral Therapy Over 9 Years |
| title_full | Dynamics of Hepatitis B Virus Pregenomic RNA in Chronic Hepatitis B Patients With Antiviral Therapy Over 9 Years |
| title_fullStr | Dynamics of Hepatitis B Virus Pregenomic RNA in Chronic Hepatitis B Patients With Antiviral Therapy Over 9 Years |
| title_full_unstemmed | Dynamics of Hepatitis B Virus Pregenomic RNA in Chronic Hepatitis B Patients With Antiviral Therapy Over 9 Years |
| title_short | Dynamics of Hepatitis B Virus Pregenomic RNA in Chronic Hepatitis B Patients With Antiviral Therapy Over 9 Years |
| title_sort | dynamics of hepatitis b virus pregenomic rna in chronic hepatitis b patients with antiviral therapy over 9 years |
| topic | chronic hepatitis B PgRNA hepatitis B virus dynamics transcription |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.851717/full |
| work_keys_str_mv | AT jialipan dynamicsofhepatitisbviruspregenomicrnainchronichepatitisbpatientswithantiviraltherapyover9years AT yutian dynamicsofhepatitisbviruspregenomicrnainchronichepatitisbpatientswithantiviraltherapyover9years AT jinghangxu dynamicsofhepatitisbviruspregenomicrnainchronichepatitisbpatientswithantiviraltherapyover9years AT haoluo dynamicsofhepatitisbviruspregenomicrnainchronichepatitisbpatientswithantiviraltherapyover9years AT ningtan dynamicsofhepatitisbviruspregenomicrnainchronichepatitisbpatientswithantiviraltherapyover9years AT yifanhan dynamicsofhepatitisbviruspregenomicrnainchronichepatitisbpatientswithantiviraltherapyover9years AT qiankang dynamicsofhepatitisbviruspregenomicrnainchronichepatitisbpatientswithantiviraltherapyover9years AT hongyuchen dynamicsofhepatitisbviruspregenomicrnainchronichepatitisbpatientswithantiviraltherapyover9years AT yuqingyang dynamicsofhepatitisbviruspregenomicrnainchronichepatitisbpatientswithantiviraltherapyover9years AT xiaoyuanxu dynamicsofhepatitisbviruspregenomicrnainchronichepatitisbpatientswithantiviraltherapyover9years |