Post-COVID central hypersomnia, a treatable trait in long COVID: 4 case reports
IntroductionFatigue is the most commonly reported post-COVID symptom. A minority of patients also report excessive daytime sleepiness, which could be a target for treatment.MethodsAmong 530 patients with a post-COVID condition, those with excessive daytime sleepiness were systematically assessed for...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1349486/full |
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| author | Clémence Morelli-Zaher Andrea Vremaroiu-Coman Nicolas Coquoz Léon Genecand Marco Altarelli Alzbeta Binkova Isabelle Frésard Pierre-Olivier Bridevaux Pierre-Olivier Bridevaux Pierre-Olivier Bridevaux Grégoire Gex Grégoire Gex Grégoire Gex |
| author_facet | Clémence Morelli-Zaher Andrea Vremaroiu-Coman Nicolas Coquoz Léon Genecand Marco Altarelli Alzbeta Binkova Isabelle Frésard Pierre-Olivier Bridevaux Pierre-Olivier Bridevaux Pierre-Olivier Bridevaux Grégoire Gex Grégoire Gex Grégoire Gex |
| author_sort | Clémence Morelli-Zaher |
| collection | DOAJ |
| description | IntroductionFatigue is the most commonly reported post-COVID symptom. A minority of patients also report excessive daytime sleepiness, which could be a target for treatment.MethodsAmong 530 patients with a post-COVID condition, those with excessive daytime sleepiness were systematically assessed for objective central hypersomnia, with exclusion of all cases not clearly attributable to SARS-CoV-2 infection.ResultsFour cases of post-COVID central hypersomnia were identified, three fulfilling the criteria of the 3rd International Classification of Sleep Disorders for idiopathic hypersomnia, and one for type II narcolepsy. We report here their clinical history, sleep examination data and treatment, with a favorable response to methylphenidate in three cases and spontaneous resolution in one case.ConclusionWe highlight the importance of identifying cases of post-COVID central hypersomnia, as it may be a treatable trait of a post-COVID condition. |
| first_indexed | 2024-03-08T02:02:54Z |
| format | Article |
| id | doaj.art-99a955bcc1a04fb884b699ff4454e2ca |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-08T02:02:54Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-99a955bcc1a04fb884b699ff4454e2ca2024-02-14T05:00:48ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-02-011510.3389/fneur.2024.13494861349486Post-COVID central hypersomnia, a treatable trait in long COVID: 4 case reportsClémence Morelli-Zaher0Andrea Vremaroiu-Coman1Nicolas Coquoz2Léon Genecand3Marco Altarelli4Alzbeta Binkova5Isabelle Frésard6Pierre-Olivier Bridevaux7Pierre-Olivier Bridevaux8Pierre-Olivier Bridevaux9Grégoire Gex10Grégoire Gex11Grégoire Gex12Division of Pulmonology, Centre Hospitalier du Valais Romand, Hôpital du Valais, Sion, SwitzerlandDivision of Pulmonology, Centre Hospitalier du Valais Romand, Hôpital du Valais, Sion, SwitzerlandDivision of Pulmonology, Centre Hospitalier du Valais Romand, Hôpital du Valais, Sion, SwitzerlandDivision of Pulmonology, Centre Hospitalier du Valais Romand, Hôpital du Valais, Sion, SwitzerlandDivision of Pulmonology, Centre Hospitalier du Valais Romand, Hôpital du Valais, Sion, SwitzerlandDivision of Pulmonology, Centre Hospitalier du Valais Romand, Hôpital du Valais, Sion, SwitzerlandDivision of Pulmonology, Centre Hospitalier du Valais Romand, Hôpital du Valais, Sion, SwitzerlandDivision of Pulmonology, Centre Hospitalier du Valais Romand, Hôpital du Valais, Sion, SwitzerlandDivision of Pulmonology, Geneva University Hospitals, Geneva, SwitzerlandFaculty of Medicine, University of Geneva, Geneva, SwitzerlandDivision of Pulmonology, Centre Hospitalier du Valais Romand, Hôpital du Valais, Sion, SwitzerlandDivision of Pulmonology, Geneva University Hospitals, Geneva, SwitzerlandFaculty of Medicine, University of Geneva, Geneva, SwitzerlandIntroductionFatigue is the most commonly reported post-COVID symptom. A minority of patients also report excessive daytime sleepiness, which could be a target for treatment.MethodsAmong 530 patients with a post-COVID condition, those with excessive daytime sleepiness were systematically assessed for objective central hypersomnia, with exclusion of all cases not clearly attributable to SARS-CoV-2 infection.ResultsFour cases of post-COVID central hypersomnia were identified, three fulfilling the criteria of the 3rd International Classification of Sleep Disorders for idiopathic hypersomnia, and one for type II narcolepsy. We report here their clinical history, sleep examination data and treatment, with a favorable response to methylphenidate in three cases and spontaneous resolution in one case.ConclusionWe highlight the importance of identifying cases of post-COVID central hypersomnia, as it may be a treatable trait of a post-COVID condition.https://www.frontiersin.org/articles/10.3389/fneur.2024.1349486/fullidiopathic hypersomniacentral hypersomnianarcolepsylong COVIDpost-COVID conditiontreatment |
| spellingShingle | Clémence Morelli-Zaher Andrea Vremaroiu-Coman Nicolas Coquoz Léon Genecand Marco Altarelli Alzbeta Binkova Isabelle Frésard Pierre-Olivier Bridevaux Pierre-Olivier Bridevaux Pierre-Olivier Bridevaux Grégoire Gex Grégoire Gex Grégoire Gex Post-COVID central hypersomnia, a treatable trait in long COVID: 4 case reports Frontiers in Neurology idiopathic hypersomnia central hypersomnia narcolepsy long COVID post-COVID condition treatment |
| title | Post-COVID central hypersomnia, a treatable trait in long COVID: 4 case reports |
| title_full | Post-COVID central hypersomnia, a treatable trait in long COVID: 4 case reports |
| title_fullStr | Post-COVID central hypersomnia, a treatable trait in long COVID: 4 case reports |
| title_full_unstemmed | Post-COVID central hypersomnia, a treatable trait in long COVID: 4 case reports |
| title_short | Post-COVID central hypersomnia, a treatable trait in long COVID: 4 case reports |
| title_sort | post covid central hypersomnia a treatable trait in long covid 4 case reports |
| topic | idiopathic hypersomnia central hypersomnia narcolepsy long COVID post-COVID condition treatment |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1349486/full |
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