Association Between Use of Anti-gout Preparations and Dementia: Nested Case–Control Nationwide Population-Based Cohort Study
Objectives: Gout is the most common form of inflammatory arthritis and was found to be independently associated with incident dementia in the elderly. However, the associations between anti-gout preparations and dementia were not well-studied.Methods: Data were collected from Taiwan's National...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-01-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2020.607808/full |
| _version_ | 1818595394829942784 |
|---|---|
| author | Tsung-Ju Chuang Tsung-Ju Chuang Yu-Hsun Wang James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei Chih-Jung Yeh |
| author_facet | Tsung-Ju Chuang Tsung-Ju Chuang Yu-Hsun Wang James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei Chih-Jung Yeh |
| author_sort | Tsung-Ju Chuang |
| collection | DOAJ |
| description | Objectives: Gout is the most common form of inflammatory arthritis and was found to be independently associated with incident dementia in the elderly. However, the associations between anti-gout preparations and dementia were not well-studied.Methods: Data were collected from Taiwan's National Health Insurance Research Database (NHIRD). A 2005–2013 retrospective cohort study was conducted, and all investigated subjects were identified by International Statistical Classification of Diseases and Related Health Problems, 9th Revision, Clinical Modification. Conditional logistic regression was used to evaluate the odds ratio of dementia in relation to different gout preparations (benzbromarone, allopurinol, sulfinpyrazone, probenecid) and number of days of anti-gout preparation use, after adjustment for potential confounding variables.Results: A total of 3,242 gout patients with and without dementia were selected from the NHIRD and included in the final analysis after 1:1 matching for age, gender, and diagnosis year of gout. In the anti-gout preparations, only use of Benzbromarone decreased the risk of dementia (adjusted OR, 0.81; 95% CI, 0.68–0.97). The result of the subgroup analysis revealed a trend toward a lower risk of dementia with longer use of benzbromarone. Use of benzbromarone for ≥180 days showed a significantly lower risk of dementia (adjusted OR, 0.72; 95% CI, 0.58–0.89). Moreover, the protective effect was more pronounced in males compared with females.Conclusion: This cohort study reveals that gout patients taking benzbromarone are at a decreased risk of developing incident dementia, especially with longer use and in male. Further prospective trials are warranted to confirm our findings. |
| first_indexed | 2024-12-16T11:15:19Z |
| format | Article |
| id | doaj.art-99a9e7d9ad9947e2b82b1cae958b2ac6 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-16T11:15:19Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-99a9e7d9ad9947e2b82b1cae958b2ac62022-12-21T22:33:37ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-01-01710.3389/fmed.2020.607808607808Association Between Use of Anti-gout Preparations and Dementia: Nested Case–Control Nationwide Population-Based Cohort StudyTsung-Ju Chuang0Tsung-Ju Chuang1Yu-Hsun Wang2James Cheng-Chung Wei3James Cheng-Chung Wei4James Cheng-Chung Wei5Chih-Jung Yeh6Division of Endocrinology and Metabolism, Department of Internal Medicine, National Defense Medical Center, Taichung Armed Forces General Hospital, Taichung, TaiwanSchool of Public Health, Chung Shan Medical University, Taichung, TaiwanDepartment of Medical Research, Chung Shan Medical University Hospital, Taichung, TaiwanDepartment of Allergy, Immunology and Rheumatology, Chung Shan Medical University Hospital, Taichung, TaiwanInstitute of Medicine, College of Medicine, Chung Shan Medical University, Taichung, TaiwanGraduate Institute of Integrated Medicine, China Medical University, Taichung, TaiwanSchool of Public Health, Chung Shan Medical University, Taichung, TaiwanObjectives: Gout is the most common form of inflammatory arthritis and was found to be independently associated with incident dementia in the elderly. However, the associations between anti-gout preparations and dementia were not well-studied.Methods: Data were collected from Taiwan's National Health Insurance Research Database (NHIRD). A 2005–2013 retrospective cohort study was conducted, and all investigated subjects were identified by International Statistical Classification of Diseases and Related Health Problems, 9th Revision, Clinical Modification. Conditional logistic regression was used to evaluate the odds ratio of dementia in relation to different gout preparations (benzbromarone, allopurinol, sulfinpyrazone, probenecid) and number of days of anti-gout preparation use, after adjustment for potential confounding variables.Results: A total of 3,242 gout patients with and without dementia were selected from the NHIRD and included in the final analysis after 1:1 matching for age, gender, and diagnosis year of gout. In the anti-gout preparations, only use of Benzbromarone decreased the risk of dementia (adjusted OR, 0.81; 95% CI, 0.68–0.97). The result of the subgroup analysis revealed a trend toward a lower risk of dementia with longer use of benzbromarone. Use of benzbromarone for ≥180 days showed a significantly lower risk of dementia (adjusted OR, 0.72; 95% CI, 0.58–0.89). Moreover, the protective effect was more pronounced in males compared with females.Conclusion: This cohort study reveals that gout patients taking benzbromarone are at a decreased risk of developing incident dementia, especially with longer use and in male. Further prospective trials are warranted to confirm our findings.https://www.frontiersin.org/articles/10.3389/fmed.2020.607808/fullgouturic aciddementiabenzbromaroneelderly |
| spellingShingle | Tsung-Ju Chuang Tsung-Ju Chuang Yu-Hsun Wang James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei Chih-Jung Yeh Association Between Use of Anti-gout Preparations and Dementia: Nested Case–Control Nationwide Population-Based Cohort Study Frontiers in Medicine gout uric acid dementia benzbromarone elderly |
| title | Association Between Use of Anti-gout Preparations and Dementia: Nested Case–Control Nationwide Population-Based Cohort Study |
| title_full | Association Between Use of Anti-gout Preparations and Dementia: Nested Case–Control Nationwide Population-Based Cohort Study |
| title_fullStr | Association Between Use of Anti-gout Preparations and Dementia: Nested Case–Control Nationwide Population-Based Cohort Study |
| title_full_unstemmed | Association Between Use of Anti-gout Preparations and Dementia: Nested Case–Control Nationwide Population-Based Cohort Study |
| title_short | Association Between Use of Anti-gout Preparations and Dementia: Nested Case–Control Nationwide Population-Based Cohort Study |
| title_sort | association between use of anti gout preparations and dementia nested case control nationwide population based cohort study |
| topic | gout uric acid dementia benzbromarone elderly |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2020.607808/full |
| work_keys_str_mv | AT tsungjuchuang associationbetweenuseofantigoutpreparationsanddementianestedcasecontrolnationwidepopulationbasedcohortstudy AT tsungjuchuang associationbetweenuseofantigoutpreparationsanddementianestedcasecontrolnationwidepopulationbasedcohortstudy AT yuhsunwang associationbetweenuseofantigoutpreparationsanddementianestedcasecontrolnationwidepopulationbasedcohortstudy AT jameschengchungwei associationbetweenuseofantigoutpreparationsanddementianestedcasecontrolnationwidepopulationbasedcohortstudy AT jameschengchungwei associationbetweenuseofantigoutpreparationsanddementianestedcasecontrolnationwidepopulationbasedcohortstudy AT jameschengchungwei associationbetweenuseofantigoutpreparationsanddementianestedcasecontrolnationwidepopulationbasedcohortstudy AT chihjungyeh associationbetweenuseofantigoutpreparationsanddementianestedcasecontrolnationwidepopulationbasedcohortstudy |