Adiponectin reduces apoptosis of diabetic cardiomyocytes by regulating miR-711/TLR4 axis

Adiponectin reduces apoptosis of diabetic cardiomyocytes by regulating miR-711/TLR4 axis

Abstract Objective To investigate the regulation of adiponectin/miR-711 on TLR4/NF-κB-mediated inflammatory response and diabetic cardiomyocyte apoptosis. Methods Diabetes models were established using rats and H9c2 cardiomyocytes. qRT-PCR was used to detect adiponectin, miR-711, and TLR4. MTT, β-ga...

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Bibliographic Details
Main Authors: Yu Zuo, Tao Xiao, Xiangdong Qiu, Zuoliang Liu, Shengnan Zhang, Na Zhou
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Adiponectin
miRNA-711
TLR4
Cardiomyocyte
Diabetes
Apoptosis
Online Access:https://doi.org/10.1186/s13098-022-00904-y

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