Medulloblastoma: From TP53 Mutations to Molecular Classification and Liquid Biopsy
A recent paradigm shift in the diagnostics of medulloblastoma allowed the distinction of four major groups defined by genetic data rather than histology. This new molecular classification correlates better with prognosis and will allow for the better clinical management of therapies targeting drugga...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-7737/12/2/267 |
| _version_ | 1797622293843673088 |
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| author | Robert H. Eibl Markus Schneemann |
| author_facet | Robert H. Eibl Markus Schneemann |
| author_sort | Robert H. Eibl |
| collection | DOAJ |
| description | A recent paradigm shift in the diagnostics of medulloblastoma allowed the distinction of four major groups defined by genetic data rather than histology. This new molecular classification correlates better with prognosis and will allow for the better clinical management of therapies targeting druggable mutations, but also offer a new combination of monitoring tumor development in real-time and treatment response by sequential liquid biopsy. This review highlights recent developments after a century of milestones in neurosurgery and radio- and chemotherapy, but also controversial theories on the cell of origin, animal models, and the use of liquid biopsy. |
| first_indexed | 2024-03-11T09:08:10Z |
| format | Article |
| id | doaj.art-99ab9c33837b4bbfa48102488bde60aa |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-11T09:08:10Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-99ab9c33837b4bbfa48102488bde60aa2023-11-16T19:14:00ZengMDPI AGBiology2079-77372023-02-0112226710.3390/biology12020267Medulloblastoma: From TP53 Mutations to Molecular Classification and Liquid BiopsyRobert H. Eibl0Markus Schneemann1c/o M. Schneemann; Department of Internal Medicine, Hospitals of Schaffhausen, 8208 Schaffhausen, SwitzerlandDepartment of Internal Medicine, Hospitals of Schaffhausen, 8208 Schaffhausen, SwitzerlandA recent paradigm shift in the diagnostics of medulloblastoma allowed the distinction of four major groups defined by genetic data rather than histology. This new molecular classification correlates better with prognosis and will allow for the better clinical management of therapies targeting druggable mutations, but also offer a new combination of monitoring tumor development in real-time and treatment response by sequential liquid biopsy. This review highlights recent developments after a century of milestones in neurosurgery and radio- and chemotherapy, but also controversial theories on the cell of origin, animal models, and the use of liquid biopsy.https://www.mdpi.com/2079-7737/12/2/267medulloblastomaTP53 mutationmolecular classificationdiagnosticsliquid biopsyanimal models |
| spellingShingle | Robert H. Eibl Markus Schneemann Medulloblastoma: From TP53 Mutations to Molecular Classification and Liquid Biopsy Biology medulloblastoma TP53 mutation molecular classification diagnostics liquid biopsy animal models |
| title | Medulloblastoma: From TP53 Mutations to Molecular Classification and Liquid Biopsy |
| title_full | Medulloblastoma: From TP53 Mutations to Molecular Classification and Liquid Biopsy |
| title_fullStr | Medulloblastoma: From TP53 Mutations to Molecular Classification and Liquid Biopsy |
| title_full_unstemmed | Medulloblastoma: From TP53 Mutations to Molecular Classification and Liquid Biopsy |
| title_short | Medulloblastoma: From TP53 Mutations to Molecular Classification and Liquid Biopsy |
| title_sort | medulloblastoma from tp53 mutations to molecular classification and liquid biopsy |
| topic | medulloblastoma TP53 mutation molecular classification diagnostics liquid biopsy animal models |
| url | https://www.mdpi.com/2079-7737/12/2/267 |
| work_keys_str_mv | AT robertheibl medulloblastomafromtp53mutationstomolecularclassificationandliquidbiopsy AT markusschneemann medulloblastomafromtp53mutationstomolecularclassificationandliquidbiopsy |